Immunosuppressant prodrug of mycophenolic acid (MPA) (Cat. No. 1505). Hydrolyzed by esterases to release MPA (a reversible inhibitor of inosine monophosphate dehydrogenase). Used to prevent organ rejection after transplantation. Displays inhibitory activity of lymphocyte functions. Inhibits type 1 collagen expression, enhances MMP-1 expression, and reduces α-smooth muscle actin gene expression.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 433.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.31 mL||11.53 mL||23.07 mL|
|5 mM||0.46 mL||2.31 mL||4.61 mL|
|10 mM||0.23 mL||1.15 mL||2.31 mL|
|50 mM||0.05 mL||0.23 mL||0.46 mL|
References are publications that support the biological activity of the product.
Allison and Eugui (1996) Purine metabolism and immunosuppressive effects of mycophenolate mofetil (MMF). Clin.Transplant. 10 77 PMID: 8680053
Roos et al (2007) In vitro evidence for a direct antifibrotic role of the immunosuppressive drug mycophenolate mofetil. J.Pharm.Exp.Ther. 321 583
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Keywords: Mycophenolate mofetil, Mycophenolate mofetil supplier, immunosuppressant, pro-drug, MMF, inhibits, inosine, monophosphate, dehydrogenase, Other, Dehydrogenases, Immunosuppressants, 4102, Tocris Bioscience
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