Mycophenolate mofetil

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Description: Inosine monophosphate dehydrogenase (IMPDH) inhibitor
Chemical Name: 6-(1,3-Dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-4-hexenoic acid 2-(4-morpholinyl)ethyl ester
Purity: ≥99% (HPLC)

Biological Activity for Mycophenolate mofetil

Mycophenolate mofetil is an immunosuppressant prodrug of mycophenolic acid (MPA) (Cat. No. 1505). Hydrolyzed by esterases to release MPA, a reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH). Used to prevent organ rejection after transplantation. Displays inhibitory activity of lymphocyte functions. Inhibits type 1 collagen expression, enhances MMP-1 expression, and reduces α-smooth muscle actin gene expression.

Compound Libraries for Mycophenolate mofetil

Mycophenolate mofetil is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Antiviral Library and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Mycophenolate mofetil

M. Wt 433.49
Formula C23H31NO7
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 128794-94-5
PubChem ID 5281078
Smiles O=C(OC2)C1=C2C(C)=C(OC)C(C/C=C(C)/CCC(OCCN3CCOCC3)=O)=C1O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Mycophenolate mofetil

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 43.35 100
ethanol 4.33 10

Preparing Stock Solutions for Mycophenolate mofetil

The following data is based on the product molecular weight 433.49. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.31 mL 11.53 mL 23.07 mL
5 mM 0.46 mL 2.31 mL 4.61 mL
10 mM 0.23 mL 1.15 mL 2.31 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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Product Datasheets for Mycophenolate mofetil

Certificate of Analysis / Product Datasheet
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References for Mycophenolate mofetil

References are publications that support the biological activity of the product.

Allison and Eugui (1996) Purine metabolism and immunosuppressive effects of mycophen. mofetil (MMF). Clin.Transplant. 10 77 PMID: 8680053

Roos et al (2007) In vitro evidence for a direct antifibrotic role of the immunosuppressive drug mycophen. mofetil. J.Pharm.Exp.Ther. 321 583

If you know of a relevant reference for Mycophenolate mofetil, please let us know.

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Keywords: Mycophenolate mofetil, Mycophenolate mofetil supplier, immunosuppressant, pro-drug, MMF, inhibits, inosine, monophosphate, dehydrogenase, IMPDH, Other, Dehydrogenases, Immunosuppressants, 4102, Tocris Bioscience

Citations for Mycophenolate mofetil

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