Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewMycophenolate mofetil is an immunosuppressant prodrug of mycophenolic acid (MPA) (Cat. No. 1505). Hydrolyzed by esterases to release MPA, a reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH). Used to prevent organ rejection after transplantation. Displays inhibitory activity of lymphocyte functions. Inhibits type 1 collagen expression, enhances MMP-1 expression, and reduces α-smooth muscle actin gene expression.
Mycophenolate mofetil is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Antiviral Library and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.
M. Wt | 433.49 |
Formula | C23H31NO7 |
Storage | Store at RT |
Purity | ≥99% (HPLC) |
CAS Number | 128794-94-5 |
PubChem ID | 5281078 |
InChI Key | RTGDFNSFWBGLEC-SYZQJQIISA-N |
Smiles | O=C(OC2)C1=C2C(C)=C(OC)C(C/C=C(C)/CCC(OCCN3CCOCC3)=O)=C1O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solvent | Max Conc. mg/mL | Max Conc. mM | |
---|---|---|---|
Solubility | |||
DMSO | 43.35 | 100 | |
ethanol | 4.33 | 10 |
The following data is based on the product molecular weight 433.49. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 2.31 mL | 11.53 mL | 23.07 mL |
5 mM | 0.46 mL | 2.31 mL | 4.61 mL |
10 mM | 0.23 mL | 1.15 mL | 2.31 mL |
50 mM | 0.05 mL | 0.23 mL | 0.46 mL |
References are publications that support the biological activity of the product.
Allison and Eugui (1996) Purine metabolism and immunosuppressive effects of mycophen. mofetil (MMF). Clin.Transplant. 10 77 PMID: 8680053
Roos et al (2007) In vitro evidence for a direct antifibrotic role of the immunosuppressive drug mycophen. mofetil. J.Pharm.Exp.Ther. 321 583
If you know of a relevant reference for Mycophenolate mofetil, please let us know.
Keywords: Mycophenolate mofetil, Mycophenolate mofetil supplier, immunosuppressant, pro-drug, MMF, inhibits, inosine, monophosphate, dehydrogenase, IMPDH, Other, Dehydrogenases, Immunosuppressants, 4102, Tocris Bioscience
Citations are publications that use Tocris products.
Currently there are no citations for Mycophenolate mofetil. Do you know of a great paper that uses Mycophenolate mofetil from Tocris? Please let us know.
There are currently no reviews for this product. Be the first to review Mycophenolate mofetil and earn rewards!
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image