Mycophenolic acid

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Cat.No. 1505 - Mycophenolic acid | C17H20O6 | CAS No. 24280-93-1
Description: Inosine monophosphatase dehydrogenase (IMPDH) inhibitor
Chemical Name: 6-(1,3-Dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-4-hexenoic acid
Purity: ≥98% (HPLC)
Citations (1)

Biological Activity for Mycophenolic acid

Mycophenolic acid is an immunosuppressive agent with antiviral and antitumor effects in vitro and in vivo. Potently inhibits inosine monophosphate dehydrogenase (IMPDH), thus inhibiting de novo GTP synthesis leading to decreased RNA and DNA synthesis. Reversibly inhibits proliferation of T and B lymphocytes and antibody formation.

Compound Libraries for Mycophenolic acid

Mycophenolic acid is also offered as part of the Tocriscreen Antiviral Library and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Mycophenolic acid

M. Wt 320.34
Formula C17H20O6
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 24280-93-1
PubChem ID 446541
Smiles COC1=C(C)C2=C(C(=O)OC2)C(O)=C1C\C=C(/C)CCC(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Mycophenolic acid

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 32.03 100

Preparing Stock Solutions for Mycophenolic acid

The following data is based on the product molecular weight 320.34. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.12 mL 15.61 mL 31.22 mL
5 mM 0.62 mL 3.12 mL 6.24 mL
10 mM 0.31 mL 1.56 mL 3.12 mL
50 mM 0.06 mL 0.31 mL 0.62 mL

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Product Datasheets for Mycophenolic acid

Certificate of Analysis / Product Datasheet
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References for Mycophenolic acid

References are publications that support the biological activity of the product.

Allison et al (1993) Mechanisms of action of mycophenolic acid. Ann.N.Y.Acad.Sci. 696 63 PMID: 7906496

Chapman et al (1997) Distinct inhibitory effects of spinal endomorphin-1 and endomorphin-2 on evoked dorsal horn neuronal responses in the rat. Br.J.Pharmacol. 122 1537 PMID: 9422796

Eugui et al (1991) Lymphocyte-selective cytostatic and immunosuppressive effects of mycophenolic acid in vitro: role of deoxyguanosine nucleotide depeletion. Scand.J.Immunol. 33 161 PMID: 1826793

Goldberg et al (1998) Pharmacological characterization of endomorphin-1 and endomorphin-2 in mouse brain. J.Pharmacol.Exp.Ther. 286 1007 PMID: 9694962

Senda et al (1995) Mycophenolic acid, an inhibitor of IMP dehydrogenase that is also an immunosuppressive agent, suppresses the cytokine-induced nitric oxide production in mouse and rat vascular endothelial cells. Transplantation 60 1143 PMID: 7482723

Zadina et al (1997) A potent and selective endogenous agonist for the μ-opiate receptor. Nature 386 499 PMID: 9087409

If you know of a relevant reference for Mycophenolic acid, please let us know.

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Keywords: Mycophenolic acid, Mycophenolic acid supplier, Inosine, monophosphatase, dehydrogenases, inhibitors, inhibits, immunosuppressant, IMPDH, Other, Dehydrogenases, Immunosuppressants, Non-selective, Antivirals, 1505, Tocris Bioscience

1 Citation for Mycophenolic acid

Citations are publications that use Tocris products. Selected citations for Mycophenolic acid include:

Gomez et al (2015) Neurogenin 3 Expressing Cells in the Human Exocrine Pancreas Have the Capacity for Endocrine Cell Fate. PLoS One 10 e0133862 PMID: 26288179

Do you know of a great paper that uses Mycophenolic acid from Tocris? Please let us know.

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