MS 21570

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Cat.No. 6298 - MS 21570 | C10H11N3S2 | CAS No. 65373-29-7
Description: GPR171 antagonist
Chemical Name: N-Methyl-5-[(phenylmethyl)thio]-1,3,4-thiazadiazol-2-amine
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

GPR171 antagonist (IC50 = 220 nM). Inhibits BigLEN (Cat.No. 6304) mediated increases in [35S]GTPγS binding in hypothalamic membranes and hyperpolarization of basolateral amygdala pyramidal neurons. Reduces anxiety-like behavior and fear conditioning in mice.

Technical Data

M. Wt 237.34
Formula C10H11N3S2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 65373-29-7
PubChem ID 805117
InChI Key KFLNRVSOQJTXDG-UHFFFAOYSA-N
Smiles CNC1=NN=C(S1)SCC2=CC=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 23.73 100
ethanol 23.73 100

Preparing Stock Solutions

The following data is based on the product molecular weight 237.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.21 mL 21.07 mL 42.13 mL
5 mM 0.84 mL 4.21 mL 8.43 mL
10 mM 0.42 mL 2.11 mL 4.21 mL
50 mM 0.08 mL 0.42 mL 0.84 mL

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References

References are publications that support the biological activity of the product.

Bobeck et al (2017) The BigLEN-GPR171 peptide receptor system within the basolateral amygdala regulates anxiety-like behavior and contextual fear conditioning. Neuropsychopharmacology 42 2527 PMID: 28425495


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Keywords: MS 21570, MS 21570 supplier, MS21570, GPR171, antagonists, antagonism, bigLEN, anxiety, 6298, Tocris Bioscience

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