BigLEN (mouse)

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Description: GPR171 agonist
Purity: ≥95% (HPLC)
Citations (1)
Reviews (1)
Literature (7)

Biological Activity for BigLEN (mouse)

BigLEN (mouse) is a GPR171 agonist. ProSAAS-derived neuropeptide. Regulates food intake in mice. Inhibits the release of glutamate onto parvocellular neurons of the paraventricular nucleus in a process dependent upon activation of postsynaptic G proteins.

Technical Data for BigLEN (mouse)

M. Wt 1756.03
Formula C78H130N24O22
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 501036-69-7
PubChem ID 131648250
Smiles [H]N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for BigLEN (mouse)

Solubility Soluble to 2 mg/ml in water

Product Datasheets for BigLEN (mouse)

Certificate of Analysis / Product Datasheet
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References for BigLEN (mouse)

References are publications that support the biological activity of the product.

Wardman et al (2011) ProSAAS-derived peptides are colocalized with neuropeptide Y and function as neuropeptides in the regulation of food intake. PLoS One 6 e28152 PMID: 22164236

Mack et al (2019) Neuropeptide PEN and its receptor GPR83: distribution, signaling, and regulation. ACS Chem.Neurosci. 10 1884 PMID: 30726666

If you know of a relevant reference for BigLEN (mouse), please let us know.

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Keywords: BigLEN (mouse), BigLEN (mouse) supplier, GPR171, agonists, agonism, neuropeptide, proSAAS, food, intake, glutamate, release, parvocellular, neurons, 6304, Tocris Bioscience

1 Citation for BigLEN (mouse)

Citations are publications that use Tocris products. Selected citations for BigLEN (mouse) include:

Richard D et al (2021) The GPR171 pathway suppresses T cell activation and limits antitumor immunity. Nat Commun 12 5857 PMID: 34615877

Do you know of a great paper that uses BigLEN (mouse) from Tocris? Please let us know.

Reviews for BigLEN (mouse)

Average Rating: 5 (Based on 1 Review.)

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By Jacob Painter on 07/07/2022
Assay Type: Ex Vivo
Species: Mouse
Cell Line/Tissue: Lymphoid Cells

I used this to screen for the activation of cell activity. I found the ideal concentrations to be around 1 - 25 uM to be ideal for my needs. It performed as expected and was easy to reconstitute. It stored at 2 mg/mL at -20C for more than 3months.

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Peptides Involved in Appetite Modulation Scientific Review

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.

Stem Cells Scientific Review

Stem Cells Scientific Review

Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.

Angiogenesis in Cancer Poster

Angiogenesis in Cancer Poster

This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.

Cancer Metabolism Poster

Cancer Metabolism Poster

This poster summarizes the main metabolic pathways in cancer cells and highlights potential targets for cancer therapeutics. Genetic changes and epigenetic modifications in cancer cells alter the regulation of cellular metabolic pathways providing potential cancer therapeutic targets.

Epigenetics in Cancer Poster

Epigenetics in Cancer Poster

This poster summarizes the main epigenetic targets in cancer. The dysregulation of epigenetic modifications has been shown to result in oncogenesis and cancer progression. Unlike genetic mutations, epigenetic alterations are considered to be reversible and thus make promising therapeutic targets.

Gut Hormones Poster

Gut Hormones Poster

The gastrointestinal tract is the largest endocrine gland in the human body, secreting hormones that affect digestion, appetite and energy expenditure. Neuropeptide modulators and gut hormones that influence appetite are reviewed in this poster.

Stem Cells Poster

Stem Cells Poster

Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.