BigLEN (mouse)

Pricing Availability Delivery Time Qty
Cat.No. 6304 - BigLEN (mouse) | Leu-Glu-Asn-Pro-Ser-Pro-Gln-Ala-Pro-Ala-Arg-Arg-Leu-Leu-Pro-Pro | CAS No. 501036-69-7
Description: GPR171 agonist
Datasheet
Citations
Literature

Biological Activity

GPR171 agonist. ProSAAS-derived neuropeptide. Regulates food intake in mice. Inhibits the release of glutamate onto parvocellular neurons of the paraventricular nucleus in a process dependent upon activation of postsynaptic G proteins.

Technical Data

M. Wt 1756.03
Formula C78H130N24O22
Sequence LENPSPQAPARRLLPP
Storage Store at -20°C
CAS Number 501036-69-7
InChI Key UEWHHQZTIIRRRA-CYUDGWNXNA-N
Smiles [H]N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 2 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 1756.03. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.57 mL 2.85 mL 5.69 mL
5 mM 0.11 mL 0.57 mL 1.14 mL
10 mM 0.06 mL 0.28 mL 0.57 mL
50 mM 0.01 mL 0.06 mL 0.11 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Wardman et al (2011) ProSAAS-derived peptides are colocalized with neuropeptide Y and function as neuropeptides in the regulation of food intake. PLoS.One. 6 e28152 PMID: 2164236


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Keywords: BigLEN (mouse), supplier, GPR171, agonists, agonism, neuropeptide, proSAAS, food, intake, glutamate, release, parvocellular, neurons, GPR171, GPR171, Tocris Bioscience

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Peptides Involved in Appetite Modulation

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