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Submit ReviewMS 15203
Description: Potent and selective GPR171 partial agonist
Chemical Name: 5-[(2-Methyl-1-oxo-2-propen-1-yl)amino]-1,3-benzenedicarboxylic acid
Purity: ≥98% (HPLC)
Biological Activity for MS 15203
MS 15203 is a potent and selective GPR171 partial agonist (EC50 = 90 nM; 28% inhibition of Forskolin activated adenylyl cyclase activity in rat hypothalamic membranes). Exhibits minimal binding to a panel of ~70 GPCRs and 10 other receptors (<22% of radioligand displaced from the target receptors). Increases neuronal activity in the paraventricular nucleus. Increases food intake and body weight in mice.
Compound Libraries for MS 15203
MS 15203 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for MS 15203
| M. Wt | 249.22 |
| Formula | C12H11NO5 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 73912-52-4 |
| PubChem ID | 773544 |
| InChI Key | NVOBVSWSDYFEMR-UHFFFAOYSA-N |
| Smiles | CC(C(NC1=CC(C(O)=O)=CC(C(O)=O)=C1)=O)=C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for MS 15203
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 24.92 | 100 |
Preparing Stock Solutions for MS 15203
The following data is based on the product molecular weight 249.22. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.01 mL | 20.06 mL | 40.13 mL |
| 5 mM | 0.8 mL | 4.01 mL | 8.03 mL |
| 10 mM | 0.4 mL | 2.01 mL | 4.01 mL |
| 50 mM | 0.08 mL | 0.4 mL | 0.8 mL |
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Product Datasheets for MS 15203
References for MS 15203
References are publications that support the biological activity of the product.
Wardman et al (2016) Identification of a small-molecule ligand that activates the neuropeptide receptor GPR171 and increases food intake Sci.Signal. 9 PMID: 27245612
If you know of a relevant reference for MS 15203, please let us know.
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Keywords: MS 15203, MS 15203 supplier, MS15203, GPR171, agonists, agonism, food, intake, body, weight, GPCR, neuropeptide, 6299, Tocris Bioscience
Citations for MS 15203
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