MRK 740

Pricing Availability   Qty
Cat.No. 6803 - MRK 740 | C25H32N6O3
Description: Potent PRDM9 inhibitor
Chemical Name: 3-(3,5-Dimethoxyphenyl)-5-(1-methyl-9-(2-methylpyridin-4-yl)-1,4,9-triazaspiro[5.5]undecan-4-yl)-1,2,4-oxadiazole
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (1)

Biological Activity

Potent PRDM9 histone methyltransferase inhibitor (IC50 = 85 nM for in vitro methylation of H3K4). Displays >100-fold selectivity over other histone methyltransferases. Inhibits H3K4 methylation in cells (IC50 = 0.8 μM).

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the MRK-740 probe summary on the SGC website.

Technical Data

M. Wt 464.56
Formula C25H32N6O3
Storage Store at -20°C
Purity ≥98% (HPLC)
PubChem ID 137331596
InChI Key NZYTZRHHBAJPKN-UHFFFAOYSA-N
Smiles CC1=CC(N2CCC3(CC2)CN(CCN3C)C4=NC(C5=CC(OC)=CC(OC)=C5)=NO4)=CC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 46.46 100
1eq. HCl 46.46 100

Preparing Stock Solutions

The following data is based on the product molecular weight 464.56. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.15 mL 10.76 mL 21.53 mL
5 mM 0.43 mL 2.15 mL 4.31 mL
10 mM 0.22 mL 1.08 mL 2.15 mL
50 mM 0.04 mL 0.22 mL 0.43 mL

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References

References are publications that support the biological activity of the product.

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Citations for MRK 740

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