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MRK 740 is a potent PRDM9 histone methyltransferase inhibitor (IC50 = 85 nM for in vitro methylation of H3K4), which displays >100-fold selectivity over other histone methyltransferases. MRK 740 inhibits H3K4 methylation in cells (IC50 = 0.8 μM).
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the MRK-740 probe summary on the SGC website.
External Portal Information
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of MRK 740 is reviewed on the chemical probes website.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 464.56. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.15 mL||10.76 mL||21.53 mL|
|5 mM||0.43 mL||2.15 mL||4.31 mL|
|10 mM||0.22 mL||1.08 mL||2.15 mL|
|50 mM||0.04 mL||0.22 mL||0.43 mL|
References are publications that support the biological activity of the product.
Allali-Hassani et al (2019) Discovery of a chemical probe for PRDM9. Nat.Commun. 10 5759 PMID: 31848333
If you know of a relevant reference for MRK 740, please let us know.
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Keywords: MRK 740, MRK 740 supplier, MRK740, histone, lysine, methyltransferase, inhibitors, inhibits, potent, PRDM9, PR, domain, zinc, finger, protein, 9, Other, Lysine, Methyltransferases, 6803, Tocris Bioscience
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