MRK 740

Pricing Availability   Qty
Cat.No. 6803 - MRK 740 | C25H32N6O3
Description: Potent PRDM9 inhibitor
Chemical Name: 3-(3,5-Dimethoxyphenyl)-5-(1-methyl-9-(2-methylpyridin-4-yl)-1,4,9-triazaspiro[5.5]undecan-4-yl)-1,2,4-oxadiazole
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews

Biological Activity

MRK 740 is a potent PRDM9 histone methyltransferase inhibitor (IC50 = 85 nM for in vitro methylation of H3K4), which displays >100-fold selectivity over other histone methyltransferases. MRK 740 inhibits H3K4 methylation in cells (IC50 = 0.8 μM).

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the MRK-740 probe summary on the SGC website.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of MRK 740 is reviewed on the chemical probes website.

Compound Libraries

MRK 740 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 464.56
Formula C25H32N6O3
Storage Store at -20°C
Purity ≥98% (HPLC)
PubChem ID 137331596
InChI Key NZYTZRHHBAJPKN-UHFFFAOYSA-N
Smiles CC1=CC(N2CCC3(CC2)CN(CCN3C)C4=NC(C5=CC(OC)=CC(OC)=C5)=NO4)=CC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 46.46 100
1eq. HCl 46.46 100

Preparing Stock Solutions

The following data is based on the product molecular weight 464.56. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.15 mL 10.76 mL 21.53 mL
5 mM 0.43 mL 2.15 mL 4.31 mL
10 mM 0.22 mL 1.08 mL 2.15 mL
50 mM 0.04 mL 0.22 mL 0.43 mL

Molarity Calculator

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Reconstitution Calculator

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References

References are publications that support the biological activity of the product.

Allali-Hassani et al (2019) Discovery of a chemical probe for PRDM9. Nat.Commun. 10 5759 PMID: 31848333


If you know of a relevant reference for MRK 740, please let us know.

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Citations for MRK 740

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