MR 16728 hydrochloride

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Cat.No. 0537 - MR 16728 hydrochloride | C23H36N2O.HCl | CAS No. 207403-36-9
Description: Stimulates ACh release
Chemical Name: N-[3-(1-Hexahydroazapinyl)propyl]-α-cyclohexyl-benzeneacetamide hydrochloride

Biological Activity

This analog of cetiedil stimulates the release of acetylcholine from synaptosomes.

Technical Data

M. Wt 393.01
Formula C23H36N2O.HCl
Storage Desiccate at -20°C
CAS Number 207403-36-9
PubChem ID 378810

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 39.3 100

Preparing Stock Solutions

The following data is based on the product molecular weight 393.01. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.54 mL 12.72 mL 25.44 mL
5 mM 0.51 mL 2.54 mL 5.09 mL
10 mM 0.25 mL 1.27 mL 2.54 mL
50 mM 0.05 mL 0.25 mL 0.51 mL

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References are publications that support the biological activity of the product.

Moulian et al (1993) The effect of MR 16728, a cetiedil analogue, on acetylcholine release in torpedo synaptosomes. Eur.J.Pharmacol. 231 407 PMID: 8449232

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Literature in this Area

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Pain Research Product Guide

A collection of over 250 products for pain research, the guide includes research tools for the study of:

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  • G-Protein-Coupled Receptors
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Nicotinic ACh Receptors Scientific Review

Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.


Pain Poster

Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.