Mps1-IN-1 dihydrochloride

Pricing Availability   Qty
Description: Selective Mps1 kinase inhibitor
Chemical Name: 1-[3-Methoxy-4-[[4-[[2-[(1-methylethyl)sulfonyl]phenyl]amino]-1H-pyrrolo[2,3-b]pyridin-6-yl]amino]phenyl]-4-piperidinol dihydrochloride
Purity: ≥98% (HPLC)
Citations (2)
Literature (2)

Biological Activity for Mps1-IN-1 dihydrochloride

Mps1-IN-1 dihydrochloride is a selective monopolar spindle 1 (Mps1) kinase inhibitor (IC50 = 367 nM); exhibits >1000 fold-selectivity against a panel of 352 kinases with the exceptions of ALK and Ltk. Disrupts the recruitment of Mad2 to kinetochores. Increases frequency of multipolar mitosis in U2OS cells.

External Portal Information for Mps1-IN-1 dihydrochloride is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of Mps1-IN-1 is reviewed on the chemical probes website.

Technical Data for Mps1-IN-1 dihydrochloride

M. Wt 608.58
Formula C28H33N5O4S.2HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 1883548-93-3
PubChem ID 91691119
Smiles CC(C)S(C(C=CC=C3)=C3NC1=CC(NC4=C(OC)C=C(N5CCC(O)CC5)C=C4)=NC2=C1C=CN2)(=O)=O.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Mps1-IN-1 dihydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 60.86 100
DMSO 60.86 100

Preparing Stock Solutions for Mps1-IN-1 dihydrochloride

The following data is based on the product molecular weight 608.58. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.64 mL 8.22 mL 16.43 mL
5 mM 0.33 mL 1.64 mL 3.29 mL
10 mM 0.16 mL 0.82 mL 1.64 mL
50 mM 0.03 mL 0.16 mL 0.33 mL

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Product Datasheets for Mps1-IN-1 dihydrochloride

References for Mps1-IN-1 dihydrochloride

References are publications that support the biological activity of the product.

Kwiatkowski et al (2010) Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function. Nat.Chem.Biol. 6 359 PMID: 20383151

Miduturu et al (2011) High-throughput kinase profiling: a more efficient approach toward the discovery of new kinase inhibitors. Chem.Biol. 18 868 PMID: 21802008

Lan and Cleveland (2010) A chemical tool box defines mitotic and interphase roles for Mps1 kinase. J.Cell Biol. 190 21 PMID: 20624898

If you know of a relevant reference for Mps1-IN-1 dihydrochloride, please let us know.

View Related Products by Product Action

View all Monopolar Spindle 1 Kinase Inhibitors

Keywords: Mps1-IN-1 dihydrochloride, Mps1-IN-1 dihydrochloride supplier, Selective, monopolar, spindle, 1, Mps1, kinases, inhibitors, inhibits, mitosis, Checkpoint, Control, Kinases, Monopolar, Spindle, Kinase, 5142, Tocris Bioscience

2 Citations for Mps1-IN-1 dihydrochloride

Citations are publications that use Tocris products. Selected citations for Mps1-IN-1 dihydrochloride include:

Marc et al (2020) Interrogation of kinase genetic interactions provides a global view of PAK1-mediated signal transduction pathways. J Biol Chem 295 16906-16919 PMID: 33060198

Marc et al (2020) Interrogation of kinase genetic interactions provides a global view of PAK1-mediated signal transduction pathways. J Biol Chem 295 16906-16919 PMID: 33453946

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Literature in this Area

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Cell Cycle and DNA Damage Research Product Guide

Cell Cycle and DNA Damage Research Product Guide

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In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.