MPro N3

Pricing Availability   Qty
Cat.No. 7230 - MPro N3 | C35H48N6O8 | CAS No. 884650-98-0
Description: Coronavirus Mpro inhibitor
Chemical Name: N-[(5-Methyl-3-isoxazolyl)carbonyl]-L-alanyl-L-valyl-N-[(1S,2E)-4-oxo-1-[[(3S)-2-oxo-3-pyrrolidinyl]methyl]-4-(phenylmethoxy)-2-buten-1-yl]-L-leucinamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (1)

Biological Activity

Coronavirus main protease (Mpro) inhibitor (respective IC50 values are 2.7, 4 and 8.8 μM for MHV-A29, HCoV-229E and FOPV replication in vitro). Inhibits viral cell infection in an MHV plaque reduction assay. Also inhibits SARS-CoV-2 viral cell entry in a plaque reduction assay (IC50 = 16.8 μM).

Technical Data

M. Wt 680.8
Formula C35H48N6O8
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 884650-98-0
PubChem ID 6323191
InChI Key IDBWWEGDLCFCTD-VNEMRZQUSA-N
Smiles CC(C[C@@H](C(N[C@H](/C=C/C(OCC1=CC=CC=C1)=O)C[C@@H]2CCNC2=O)=O)NC([C@H](C(C)C)NC([C@@H](NC(C3=NOC(C)=C3)=O)C)=O)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 34.04 50

Preparing Stock Solutions

The following data is based on the product molecular weight 680.8. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 2.94 mL 14.69 mL 29.38 mL
2.5 mM 0.59 mL 2.94 mL 5.88 mL
5 mM 0.29 mL 1.47 mL 2.94 mL
25 mM 0.06 mL 0.29 mL 0.59 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

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Dilution Calculator

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References

References are publications that support the biological activity of the product.

Yang et al (2005) Design of wide-spectrum inhibitors targeting coronavirus main proteases. PLoS.One. 10 PMID: 16128623

Jin et al (2020) Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors. Nature. 582 289 PMID: 32272481


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Citations for MPro N3

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