You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Coronavirus main protease (Mpro) inhibitor (respective IC50 values are 2.7, 4 and 8.8 μM for MHV-A29, HCoV-229E and FOPV replication in vitro). Inhibits viral cell infection in an MHV plaque reduction assay. Also inhibits SARS-CoV-2 viral cell entry in a plaque reduction assay (IC50 = 16.8 μM).
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 680.8. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||2.94 mL||14.69 mL||29.38 mL|
|2.5 mM||0.59 mL||2.94 mL||5.88 mL|
|5 mM||0.29 mL||1.47 mL||2.94 mL|
|25 mM||0.06 mL||0.29 mL||0.59 mL|
References are publications that support the biological activity of the product.
Yang et al (2005) Design of wide-spectrum inhibitors targeting coronavirus main proteases. PLoS.One. 10 PMID: 16128623
Jin et al (2020) Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors. Nature. 582 289 PMID: 32272481
If you know of a relevant reference for MPro N3, please let us know.
View Related Products by Product Action
Keywords: MPro N3, MPro N3 supplier, MProN3, coronavirus, main, protease, proteinase, inhibitors, inhibits, Mpro, 3CLpro, MHV-A29,, HCoV-229E, FOPV, SARS-CoV, SARS-CoV-2, 3C, and, 3CL, Proteases, Coronavirus, 7230, Tocris Bioscience
Citations for MPro N3
Citations are publications that use Tocris products.
Currently there are no citations for MPro N3. Do you know of a great paper that uses MPro N3 from Tocris? Please let us know.
Reviews for MPro N3
There are currently no reviews for this product. Be the first to review MPro N3 and earn rewards!
Have you used MPro N3?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.