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MPro N3 New
Coronavirus main protease (Mpro) inhibitor (respective IC50 values are 2.7, 4 and 8.8 μM for MHV-A29, HCoV-229E and FOPV replication in vitro). Inhibits viral cell infection in an MHV plaque reduction assay. Also inhibits SARS-CoV-2 viral cell entry in a plaque reduction assay (IC50 = 16.8 μM).
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 680.8. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||2.94 mL||14.69 mL||29.38 mL|
|2.5 mM||0.59 mL||2.94 mL||5.88 mL|
|5 mM||0.29 mL||1.47 mL||2.94 mL|
|25 mM||0.06 mL||0.29 mL||0.59 mL|
References are publications that support the biological activity of the product.
Yang et al (2005) Design of wide-spectrum inhibitors targeting coronavirus main proteases. PLoS.One. 10 PMID: 16128623
Jin et al (2020) Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors. Nature. 582 289 PMID: 32272481
If you know of a relevant reference for MPro N3, please let us know.
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