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Biological Activity for MPro N3
MPro N3 is a coronavirus main protease (Mpro) inhibitor (respective IC50 values are 2.7, 4 and 8.8 μM for MHV-A29, HCoV-229E and FOPV replication in vitro). Inhibits viral cell infection in an MHV plaque reduction assay. Also inhibits SARS-CoV-2 viral cell entry in a plaque reduction assay (IC50 = 16.8 μM).
Compound Libraries for MPro N3
Technical Data for MPro N3
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for MPro N3
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for MPro N3
The following data is based on the product molecular weight 680.8. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||2.94 mL||14.69 mL||29.38 mL|
|2.5 mM||0.59 mL||2.94 mL||5.88 mL|
|5 mM||0.29 mL||1.47 mL||2.94 mL|
|25 mM||0.06 mL||0.29 mL||0.59 mL|
References for MPro N3
References are publications that support the biological activity of the product.
Yang et al (2005) Design of wide-spectrum inhibitors targeting coronavirus main proteases. PLoS.One. 10 PMID: 16128623
Jin et al (2020) Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors. Nature. 582 289 PMID: 32272481
If you know of a relevant reference for MPro N3, please let us know.
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1 Citation for MPro N3
Citations are publications that use Tocris products. Selected citations for MPro N3 include:
Ghislaine et al (2021) Design of modular autoproteolytic gene switches responsive to anti-coronavirus drug candidates. Nat Commun 12 6786 PMID: 34811361
Do you know of a great paper that uses MPro N3 from Tocris? Please let us know.
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