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MPC 6827 hydrochloride

Cat. No. 5231 Submit a Review Datasheet / COA / SDS
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Cat.No. 5231 - MPC 6827 hydrochloride | C17H17N3O.HCl | CAS No. 917369-31-4
Description: Inhibitor of microtubule polymerization; antimitotic and antitumor
Chemical Name: N-(4-Methoxyphenyl)-N,2-dimethyl-4-quinazolinamine hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
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Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Potent inhibitor of microtubule formation (IC50 = 1.5 - 3.4 nM); inhibits polymerization of tubulin in vitro and disrupts microtubule formation in several cancer cell lines. Inhibits tumor growth in vitro and in vivo; exhibits pro-apoptotic characteristics. Brain penetrant.

Compound Libraries

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Technical Data

M. Wt 315.8
Formula C17H17N3O.HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 917369-31-4
PubChem ID 11638255
InChI Key VYUWDIKZJLOZJL-UHFFFAOYSA-N
Smiles CC2=NC1=CC=CC=C1C(N(C)C3=CC=C(OC)C=C3)=N2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 31.58 100
DMSO 31.58 100

Preparing Stock Solutions

The following data is based on the product molecular weight 315.8. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.17 mL 15.83 mL 31.67 mL
5 mM 0.63 mL 3.17 mL 6.33 mL
10 mM 0.32 mL 1.58 mL 3.17 mL
50 mM 0.06 mL 0.32 mL 0.63 mL

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References

References are publications that support the biological activity of the product.

Mahal et al (2014) Effects of the tumor-vasculature-disrupting agent verubulin and two heteroaryl analogues on cancer cells, endothelial cells, and blood vessels. ChemMedChem. 9 847 PMID: 24678059

Kasibhatla et al (2007) MPC-6827: a small-molecule inhibitor of microtubule formation that is not a substrate for multidrug resistance pumps. Cancer Res. 67 5865 PMID: 17575155

Sirisoma et al (2009) Discovery of N-(4-methoxyphenyl)-N,2-dimethylquinazolin-4-amine, a potent apoptosis inducer and efficacious anticancer agent with high blood brain barrier penetration. J.Med.Chem. 52 2341 PMID: 19296653

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