MPC 6827 hydrochloride

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Description: Inhibitor of microtubule polymerization; antimitotic and antitumor
Chemical Name: N-(4-Methoxyphenyl)-N,2-dimethyl-4-quinazolinamine hydrochloride
Purity: ≥98% (HPLC)
Citations (2)
Literature (1)

Biological Activity for MPC 6827 hydrochloride

MPC 6827 hydrochloride is a potent inhibitor of microtubule formation (IC50 = 1.5 - 3.4 nM); inhibits polymerization of tubulin in vitro and disrupts microtubule formation in several cancer cell lines. Inhibits tumor growth in vitro and in vivo; exhibits pro-apoptotic characteristics. Brain penetrant.

Technical Data for MPC 6827 hydrochloride

M. Wt 315.8
Formula C17H17N3O.HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 917369-31-4
PubChem ID 11638255
Smiles CC2=NC1=CC=CC=C1C(N(C)C3=CC=C(OC)C=C3)=N2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for MPC 6827 hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 31.58 100
DMSO 31.58 100

Preparing Stock Solutions for MPC 6827 hydrochloride

The following data is based on the product molecular weight 315.8. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.17 mL 15.83 mL 31.67 mL
5 mM 0.63 mL 3.17 mL 6.33 mL
10 mM 0.32 mL 1.58 mL 3.17 mL
50 mM 0.06 mL 0.32 mL 0.63 mL

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Product Datasheets for MPC 6827 hydrochloride

References for MPC 6827 hydrochloride

References are publications that support the biological activity of the product.

Mahal et al (2014) Effects of the tumor-vasculature-disrupting agent verubulin and two heteroaryl analogues on cancer cells, endothelial cells, and blood vessels. ChemMedChem. 9 847 PMID: 24678059

Kasibhatla et al (2007) MPC-6827: a small-molecule inhibitor of microtubule formation that is not a substrate for multidrug resistance pumps. Cancer Res. 67 5865 PMID: 17575155

Sirisoma et al (2009) Discovery of N-(4-methoxyphenyl)-N,2-dimethylquinazolin-4-amine, a potent apoptosis inducer and efficacious anticancer agent with high blood brain barrier penetration. J.Med.Chem. 52 2341 PMID: 19296653

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2 Citations for MPC 6827 hydrochloride

Citations are publications that use Tocris products. Selected citations for MPC 6827 hydrochloride include:

Christopher T et al (2022) Initial Evaluations of the Microtubule-Based PET Radiotracer, [11C]MPC-6827 in a Rodent Model of Cocaine Abuse. Front Med (Lausanne) 9 817274 PMID: 35295607

Suzanne et al (2022) Preliminary mechanistic insights of a brain-penetrant microtubule imaging PET ligand in a tau-knockout mouse model. EJNMMI Res 12 41 PMID: 35881263

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Cell Cycle and DNA Damage Research Product Guide

Cell Cycle and DNA Damage Research Product Guide

This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:

  • Cell Cycle and Mitosis
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  • Ubiquitin Proteasome Pathway
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