You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
MPC 6827 hydrochloride
Potent inhibitor of microtubule formation (IC50 = 1.5 - 3.4 nM); inhibits polymerization of tubulin in vitro and disrupts microtubule formation in several cancer cell lines. Inhibits tumor growth in vitro and in vivo; exhibits pro-apoptotic characteristics. Brain penetrant.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 315.8. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.17 mL||15.83 mL||31.67 mL|
|5 mM||0.63 mL||3.17 mL||6.33 mL|
|10 mM||0.32 mL||1.58 mL||3.17 mL|
|50 mM||0.06 mL||0.32 mL||0.63 mL|
References are publications that support the biological activity of the product.
Mahal et al (2014) Effects of the tumor-vasculature-disrupting agent verubulin and two heteroaryl analogues on cancer cells, endothelial cells, and blood vessels. ChemMedChem. 9 847 PMID: 24678059
Kasibhatla et al (2007) MPC-6827: a small-molecule inhibitor of microtubule formation that is not a substrate for multidrug resistance pumps. Cancer Res. 67 5865 PMID: 17575155
Sirisoma et al (2009) Discovery of N-(4-methoxyphenyl)-N,2-dimethylquinazolin-4-amine, a potent apoptosis inducer and efficacious anticancer agent with high blood brain barrier penetration. J.Med.Chem. 52 2341 PMID: 19296653
If you know of a relevant reference for MPC 6827 hydrochloride, please let us know.
View Related Products by Target
Keywords: MPC 6827 hydrochloride, MPC 6827 hydrochloride supplier, MPC6827, hydrochloride, Potent, microtubule, formation, inhibitors, inhibits, proapoptotic, antitumor, blood, brain, barrier, permeable, MDR, multi, drug, resistant, antimitotic, Microtubules, Apoptosis, Inducers, Cell, Cycle, Inhibitors, 5231, Tocris Bioscience
Citations for MPC 6827 hydrochloride
Citations are publications that use Tocris products.
Currently there are no citations for MPC 6827 hydrochloride. Do you know of a great paper that uses MPC 6827 hydrochloride from Tocris? Please let us know.
Reviews for MPC 6827 hydrochloride
There are currently no reviews for this product. Be the first to review MPC 6827 hydrochloride and earn rewards!
Have you used MPC 6827 hydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.