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MPC 6827 hydrochloride
Biological Activity for MPC 6827 hydrochloride
MPC 6827 hydrochloride is a potent inhibitor of microtubule formation (IC50 = 1.5 - 3.4 nM); inhibits polymerization of tubulin in vitro and disrupts microtubule formation in several cancer cell lines. Inhibits tumor growth in vitro and in vivo; exhibits pro-apoptotic characteristics. Brain penetrant.
Technical Data for MPC 6827 hydrochloride
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for MPC 6827 hydrochloride
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for MPC 6827 hydrochloride
The following data is based on the product molecular weight 315.8. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.17 mL||15.83 mL||31.67 mL|
|5 mM||0.63 mL||3.17 mL||6.33 mL|
|10 mM||0.32 mL||1.58 mL||3.17 mL|
|50 mM||0.06 mL||0.32 mL||0.63 mL|
Product Datasheets for MPC 6827 hydrochloride
References for MPC 6827 hydrochloride
References are publications that support the biological activity of the product.
Mahal et al (2014) Effects of the tumor-vasculature-disrupting agent verubulin and two heteroaryl analogues on cancer cells, endothelial cells, and blood vessels. ChemMedChem. 9 847 PMID: 24678059
Kasibhatla et al (2007) MPC-6827: a small-molecule inhibitor of microtubule formation that is not a substrate for multidrug resistance pumps. Cancer Res. 67 5865 PMID: 17575155
Sirisoma et al (2009) Discovery of N-(4-methoxyphenyl)-N,2-dimethylquinazolin-4-amine, a potent apoptosis inducer and efficacious anticancer agent with high blood brain barrier penetration. J.Med.Chem. 52 2341 PMID: 19296653
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Citations for MPC 6827 hydrochloride
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Cell Cycle and DNA Damage Research Product Guide
This product guide provides a review of the cell cycle and DNA damage research area and lists over 170 products, including research tools for:
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