MPC 6827 hydrochloride

Cat. No. 5231 COA / Product Datasheet SDS

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Cat.No. 5231 - MPC 6827 hydrochloride | C17H17N3O.HCl | CAS No. 917369-31-4

Description: Inhibitor of microtubule polymerization; antimitotic and antitumor

Chemical Name: N-(4-Methoxyphenyl)-N,2-dimethyl-4-quinazolinamine hydrochloride

Purity: ≥98% (HPLC)

Datasheet

Citations

Reviews

Literature

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Potent inhibitor of microtubule formation (IC₅₀ = 1.5 - 3.4 nM); inhibits polymerization of tubulin in vitro and disrupts microtubule formation in several cancer cell lines. Inhibits tumor growth in vitro and in vivo; exhibits pro-apoptotic characteristics. Brain penetrant.

Compound Libraries

MPC 6827 hydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	315.8
Formula	C₁₇H₁₇N₃O.HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	917369-31-4
PubChem ID	11638255
InChI Key	VYUWDIKZJLOZJL-UHFFFAOYSA-N
Smiles	CC2=NC1=CC=CC=C1C(N(C)C3=CC=C(OC)C=C3)=N2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	31.58	100
	DMSO	31.58	100

Preparing Stock Solutions

The following data is based on the product molecular weight 315.8. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.17 mL	15.83 mL	31.67 mL
5 mM	0.63 mL	3.17 mL	6.33 mL
10 mM	0.32 mL	1.58 mL	3.17 mL
50 mM	0.06 mL	0.32 mL	0.63 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Mahal et al (2014) Effects of the tumor-vasculature-disrupting agent verubulin and two heteroaryl analogues on cancer cells, endothelial cells, and blood vessels. ChemMedChem. 9 847 PMID: 24678059

Kasibhatla et al (2007) MPC-6827: a small-molecule inhibitor of microtubule formation that is not a substrate for multidrug resistance pumps. Cancer Res. 67 5865 PMID: 17575155

Sirisoma et al (2009) Discovery of N-(4-methoxyphenyl)-N,2-dimethylquinazolin-4-amine, a potent apoptosis inducer and efficacious anticancer agent with high blood brain barrier penetration. J.Med.Chem. 52 2341 PMID: 19296653

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Citations for MPC 6827 hydrochloride

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Literature in this Area

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Cancer Research Product Guide

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