MNI caged kainic acid

Discontinued Product

MNI caged kainic acid (Cat. No. 2225) has been withdrawn from sale for commercial reasons.
Cat.No. 2225 - MNI caged kainic acid | C19H23N3O6 | CAS No. 1315378-75-6
Description: Caged kainic acid
Chemical Name: (2S,3S,4S)-Carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid 4-methoxy-7-nitro-1H-indolinyl amide
Purity: ≥99% (HPLC)
Citations (1)
Literature (4)

Biological Activity for MNI caged kainic acid

Kainic acid (Cat.No. 0222) caged with the photosensitive 4-methoxy-7-nitroindolinyl group. Generates large inward currents at resting membrane potential upon wide field photolysis in Purkinje neurons. Selectively photoactivates kainate receptors when used in conjunction with an AMPA antagonist, such as GYKI 53655 (Cat.No. 2555). Suitable for uncaging with 300-380 nm excitation. Exhibits rapid uncaging rate relative to ionotropic glutamate receptor activation. Also suitable for two-photon uncaging experiments at 720 nm.

Licensing Information

Sold under licence from the Medical Research Council

Technical Data for MNI caged kainic acid

M. Wt 389.4
Formula C19H23N3O6
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 1315378-75-6
PubChem ID 57414719
Smiles C=[C@@](C)[C@@H]1[C@H](CC(N2C(C([N+]([O-])=O)=CC=C3OC)=C3CC2)=O)[C@@H]([C@](O)=O)NC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for MNI caged kainic acid

Certificate of Analysis / Product Datasheet
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References for MNI caged kainic acid

References are publications that support the biological activity of the product.

Maier et al (2005) Comparative analysis of inhibitor effects of caged ligands for the NMDA receptor. J.Neurosci.Meths. 142 1 PMID: 15652611

Palma-Cerda et al (2013) New caged neurotransmitter analogues based on methoxy-nitroindole and nitrophenylethoxycarbonyl caging groups are selective for glutamate receptor subtypes. Neuropharmacology 63 624 PMID: 22609535

Palma-Cerda et al (2012) New caged neurotransmitter analogs selective for glutamate receptor sub-types based on methoxynitroindoline and nitrophenylethoxycarbonyl caging groups. Neuropharmacology. 63 624 PMID: 22609535

Passlick and Ellis-Davies et al (2017) Comparative one- and two-photon uncaging of MNI-glutamate and MNI-kainate on hippocampal CA1 neurons. J.Neurosci.Methods. PMID: 29051090

Keywords: MNI caged kainic acid, MNI caged kainic acid supplier, MNI, caged, compounds, kainic, acid, 4-methoxy-7-nitroindolinyl, photosensitive, neurotoxin, iGluR, ionotropic, glutamate, kainate, receptors, agonists, Caged, Glutamate, Compounds, Kainate, Receptors, 2225, Tocris Bioscience

1 Citation for MNI caged kainic acid

Citations are publications that use Tocris products. Selected citations for MNI caged kainic acid include:

Passlick and Ellis-Davies (2017) Comparative one- and two-photon uncaging of MNI-glutamate and MNI-kainate on hippocampal CA1 neurons. J.Neurosci.Methods. 293 321 PMID: 29051090

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