Potent, synthetic, cytotoxic analog of dolastatin 10 (Cat. No. 3375). Suppresses tumor cell viability in vitro (GIC50 values are 0.22, 0.49 and 0.54 nM in BT474, MDA-MB-361-DYT2 and N87 cells, respectively). MMAE derivatives have been shown to induce regression of established tumor xenografts when conjugated to tumor targeting antibodies via a protease-cleavable linker.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 717.98. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.39 mL||6.96 mL||13.93 mL|
|5 mM||0.28 mL||1.39 mL||2.79 mL|
|10 mM||0.14 mL||0.7 mL||1.39 mL|
|50 mM||0.03 mL||0.14 mL||0.28 mL|
References are publications that support the products' biological activity.
Doronina et al (2003) Development of potent monoclonal antibody auristatin conjugates for cancer therapy. Nat.Biotechnol. 21 778 PMID: 12778055
Maderna et al (2014) Discovery of cytotoxic dolastatin 10 analogues with N-terminal modifications. J.Med.Chem. 57 10527 PMID: 25431858
If you know of a relevant reference for MMAE, please let us know.
Keywords: MMAE, supplier, monomethylauristatin, E, Potent, cytotoxic, dolastatin, 10, analogues, anticancer, antitumour, antitumor, tubulin, polymerization, agents, Microtubules, Mitosis, Microtubules, Tocris Bioscience
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