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Potent, synthetic, cytotoxic analog of dolastatin 10 (Cat. No. 3375). Suppresses tumor cell viability in vitro (GIC50 values are 0.22, 0.49 and 0.54 nM in BT474, MDA-MB-361-DYT2 and N87 cells, respectively). MMAE derivatives have been shown to induce regression of established tumor xenografts when conjugated to tumor targeting antibodies via a protease-cleavable linker.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Doronina et al (2003) Development of potent monoclonal antibody auristatin conjugates for cancer therapy. Nat.Biotechnol. 21 778 PMID: 12778055
Maderna et al (2014) Discovery of cytotoxic dolastatin 10 analogues with N-terminal modifications. J.Med.Chem. 57 10527 PMID: 25431858
Keywords: MMAE, MMAE supplier, monomethylauristatin, E, Potent, cytotoxic, dolastatin, 10, analogues, anticancer, antitumour, antitumor, tubulin, polymerization, agents, Microtubules, Mitosis, 5683, Tocris Bioscience
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