MMAE

Discontinued Product

MMAE (Cat. No. 5683) has been withdrawn from sale for commercial reasons.
Cat.No. 5683 - MMAE | C39H67N5O7 | CAS No. 474645-27-7
Description: Potent dolastatin 10 analog; antitumor
Chemical Name: N-Methyl-L-valyl-N-[(1S,2R)-4-[(2S)-2-[(1R,2R)-3-[[(1R,2S)-2-hydroxy-1-methyl-2-phenylethyl]amino]-1-methoxy-2-methyl-3-oxopropyl]-1-pyrrolidinyl]-2-methoxy-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl-L-valinamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)

Biological Activity

Potent, synthetic, cytotoxic analog of dolastatin 10 (Cat. No. 3375). Suppresses tumor cell viability in vitro (GIC50 values are 0.22, 0.49 and 0.54 nM in BT474, MDA-MB-361-DYT2 and N87 cells, respectively). MMAE derivatives have been shown to induce regression of established tumor xenografts when conjugated to tumor targeting antibodies via a protease-cleavable linker.

Technical Data

M. Wt 717.98
Formula C39H67N5O7
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 474645-27-7
PubChem ID 11542188
InChI Key DASWEROEPLKSEI-UIJRFTGLSA-N
Smiles O=C(C[C@@H](OC)[C@@H](N(C)[C@@]([C@H](C(C)C)NC([C@H](C(C)C)NC)=O)=O)[C@@H](C)CC)N1[C@@]([C@@H]([C@H](C(N[C@@H]([C@@H](O)[C@]2=CC=CC=C2)C)=O)C)OC)([H])CCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References

References are publications that support the biological activity of the product.

Doronina et al (2003) Development of potent monoclonal antibody auristatin conjugates for cancer therapy. Nat.Biotechnol. 21 778 PMID: 12778055

Maderna et al (2014) Discovery of cytotoxic dolastatin 10 analogues with N-terminal modifications. J.Med.Chem. 57 10527 PMID: 25431858

Keywords: MMAE, MMAE supplier, monomethylauristatin, E, Potent, cytotoxic, dolastatin, 10, analogues, anticancer, antitumour, antitumor, tubulin, polymerization, agents, Microtubules, Mitosis, 5683, Tocris Bioscience

Citations for MMAE

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Currently there are no citations for MMAE.

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Literature in this Area

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