MMAE

Pricing Availability Delivery Time Qty
Cat.No. 5683 - MMAE | C39H67N5O7 | CAS No. 474645-27-7
Description: Potent dolastatin 10 analog; antitumor
Chemical Name: N-Methyl-L-valyl-N-[(1S,2R)-4-[(2S)-2-[(1R,2R)-3-[[(1R,2S)-2-hydroxy-1-methyl-2-phenylethyl]amino]-1-methoxy-2-methyl-3-oxopropyl]-1-pyrrolidinyl]-2-methoxy-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl-L-valinamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent, synthetic, cytotoxic analog of dolastatin 10 (Cat. No. 3375). Suppresses tumor cell viability in vitro (GIC50 values are 0.22, 0.49 and 0.54 nM in BT474, MDA-MB-361-DYT2 and N87 cells, respectively). MMAE derivatives have been shown to induce regression of established tumor xenografts when conjugated to tumor targeting antibodies via a protease-cleavable linker.

Technical Data

M. Wt 717.98
Formula C39H67N5O7
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 474645-27-7
PubChem ID 11542188
InChI Key DASWEROEPLKSEI-UIJRFTGLSA-N
Smiles O=C(C[C@@H](OC)[C@@H](N(C)[C@@]([C@H](C(C)C)NC([C@H](C(C)C)NC)=O)=O)[C@@H](C)CC)N1[C@@]([C@@H]([C@H](C(N[C@@H]([C@@H](O)[C@]2=CC=CC=C2)C)=O)C)OC)([H])CCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 71.8 100

Preparing Stock Solutions

The following data is based on the product molecular weight 717.98. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.39 mL 6.96 mL 13.93 mL
5 mM 0.28 mL 1.39 mL 2.79 mL
10 mM 0.14 mL 0.7 mL 1.39 mL
50 mM 0.03 mL 0.14 mL 0.28 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Doronina et al (2003) Development of potent monoclonal antibody auristatin conjugates for cancer therapy. Nat.Biotechnol. 21 778 PMID: 12778055

Maderna et al (2014) Discovery of cytotoxic dolastatin 10 analogues with N-terminal modifications. J.Med.Chem. 57 10527 PMID: 25431858


If you know of a relevant reference for MMAE, please let us know.

Keywords: MMAE, supplier, monomethylauristatin, E, Potent, cytotoxic, dolastatin, 10, analogues, anticancer, antitumour, antitumor, tubulin, polymerization, agents, Microtubules, Mitosis, Microtubules, Tocris Bioscience

Citations for MMAE

Citations are publications that use Tocris products.

Currently there are no citations for MMAE. Do you know of a great paper that uses MMAE from Tocris? If so please let us know.

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