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Dolastatin 10 trifluoroacetate is a tubulin polymerization inhibitor. Noncompetitively inhibits binding of radiolabeled vincristine to tubulin (Ki = 1.4 μM) and induces tubulin aggregation in vitro.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Bai et al (1990) Binding of dolastatin 10 to tubulin at a distinct site for peptide antimitotic agents near the exchangeable nucleotide and vinca alkaloid sites. J.Biol.Chem. 265 17141 PMID: 2211617
Bai et al (1995) Interaction of dolastatin 10 with tubulin: induction of aggregation and binding and dissociation reactions. Mol.Pharmacol. 47 965 PMID: 7746283
Keywords: Dolastatin 10 trifluoroacetate, Dolastatin 10 trifluoroacetate supplier, tubulin, polymerization, inhibitors, inhibits, aggregation, inducers, induces, microtubule, 110417-88-4, Microtubules, Mitosis, 3375, Tocris Bioscience
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