Dolastatin 10 trifluoroacetate

Discontinued Product

Dolastatin 10 trifluoroacetate (Cat. No. 3375) has been withdrawn from sale for commercial reasons.
Description: Tubulin polymerization inhibitor
Chemical Name: N,N-Dimethyl-L-valyl-N-[(1S,2R)-2-methoxy-4-[(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[[(1S)-2-phenyl-1-(2-thiazol)ethyl]amino]propyl]-1-pyrrolidinyl]-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl--valinamide trifluoroacetate
Purity: ≥95% (HPLC)
Datasheet
Citations
Reviews
Literature (2)

Biological Activity for Dolastatin 10 trifluoroacetate

Dolastatin 10 trifluoroacetate is a tubulin polymerization inhibitor. Noncompetitively inhibits binding of radiolabeled vincristine to tubulin (Ki = 1.4 μM) and induces tubulin aggregation in vitro.

Technical Data for Dolastatin 10 trifluoroacetate

M. Wt 899.11
Formula C42H68N6O6S.CF3CO2H
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 2342568-65-2
PubChem ID 9810929
InChI Key OFDNQWIFNXBECV-VFSYNPLYSA-N
Smiles O=C(C[C@@H](OC)[C@@H](N(C)C([C@H](C(C)C)NC([C@@H](N(C)C)C(C)C)=O)=O)[C@@H](C)CC)N1[C@@]([C@H](OC)[C@@H](C)C(N[C@@H](CC3=CC=CC=C3)C2=NC=CS2)=O)([H])CCC1.FC(C(O)=O)(F)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Dolastatin 10 trifluoroacetate

Certificate of Analysis / Product Datasheet
Select another batch:

References for Dolastatin 10 trifluoroacetate

References are publications that support the biological activity of the product.

Bai et al (1990) Binding of dolastatin 10 to tubulin at a distinct site for peptide antimitotic agents near the exchangeable nucleotide and vinca alkaloid sites. J.Biol.Chem. 265 17141 PMID: 2211617

Bai et al (1995) Interaction of dolastatin 10 with tubulin: induction of aggregation and binding and dissociation reactions. Mol.Pharmacol. 47 965 PMID: 7746283

Keywords: Dolastatin 10 trifluoroacetate, Dolastatin 10 trifluoroacetate supplier, tubulin, polymerization, inhibitors, inhibits, aggregation, inducers, induces, microtubule, 110417-88-4, Microtubules, Mitosis, 3375, Tocris Bioscience

Citations for Dolastatin 10 trifluoroacetate

Citations are publications that use Tocris products.

Currently there are no citations for Dolastatin 10 trifluoroacetate.

Reviews for Dolastatin 10 trifluoroacetate

There are currently no reviews for this product. Be the first to review Dolastatin 10 trifluoroacetate and earn rewards!

Have you used Dolastatin 10 trifluoroacetate?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer Research Product Guide

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Cell Cycle and DNA Damage Research Product Guide

Cell Cycle and DNA Damage Research Product Guide

This product guide provides a review of the cell cycle and DNA damage research area and lists over 170 products, including research tools for:

  • Cell Cycle and Mitosis
  • DNA Damage Repair
  • Targeted Protein Degradation
  • Ubiquitin Proteasome Pathway
  • Chemotherapy Targets