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Dolastatin 10 trifluoroacetate
Biological Activity for Dolastatin 10 trifluoroacetate
Dolastatin 10 trifluoroacetate is a tubulin polymerization inhibitor. Noncompetitively inhibits binding of radiolabeled vincristine to tubulin (Ki = 1.4 μM) and induces tubulin aggregation in vitro.
Technical Data for Dolastatin 10 trifluoroacetate
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Dolastatin 10 trifluoroacetate
|Solubility||Soluble in DMSO|
Product Datasheets for Dolastatin 10 trifluoroacetate
References for Dolastatin 10 trifluoroacetate
References are publications that support the biological activity of the product.
Bai et al (1990) Binding of dolastatin 10 to tubulin at a distinct site for peptide antimitotic agents near the exchangeable nucleotide and vinca alkaloid sites. J.Biol.Chem. 265 17141 PMID: 2211617
Bai et al (1995) Interaction of dolastatin 10 with tubulin: induction of aggregation and binding and dissociation reactions. Mol.Pharmacol. 47 965 PMID: 7746283
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Keywords: Dolastatin 10 trifluoroacetate, Dolastatin 10 trifluoroacetate supplier, tubulin, polymerization, inhibitors, inhibits, aggregation, inducers, induces, microtubule, 110417-88-4, Microtubules, Mitosis, 3375, Tocris Bioscience
Citations for Dolastatin 10 trifluoroacetate
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