Dolastatin 10 trifluoroacetate

Discontinued Product

Dolastatin 10 trifluoroacetate (Cat. No. 3375) has been withdrawn from sale for commercial reasons.
Description: Tubulin polymerization inhibitor
Chemical Name: N,N-Dimethyl-L-valyl-N-[(1S,2R)-2-methoxy-4-[(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[[(1S)-2-phenyl-1-(2-thiazol)ethyl]amino]propyl]-1-pyrrolidinyl]-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl--valinamide trifluoroacetate
Purity: ≥95% (HPLC)
Literature (1)

Biological Activity for Dolastatin 10 trifluoroacetate

Dolastatin 10 trifluoroacetate is a tubulin polymerization inhibitor. Noncompetitively inhibits binding of radiolabeled vincristine to tubulin (Ki = 1.4 μM) and induces tubulin aggregation in vitro.

Technical Data for Dolastatin 10 trifluoroacetate

M. Wt 899.11
Formula C42H68N6O6S.CF3CO2H
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 2342568-65-2
PubChem ID 9810929
Smiles O=C(C[C@@H](OC)[C@@H](N(C)C([C@H](C(C)C)NC([C@@H](N(C)C)C(C)C)=O)=O)[C@@H](C)CC)N1[C@@]([C@H](OC)[C@@H](C)C(N[C@@H](CC3=CC=CC=C3)C2=NC=CS2)=O)([H])CCC1.FC(C(O)=O)(F)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Dolastatin 10 trifluoroacetate

Certificate of Analysis / Product Datasheet
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References for Dolastatin 10 trifluoroacetate

References are publications that support the biological activity of the product.

Bai et al (1990) Binding of dolastatin 10 to tubulin at a distinct site for peptide antimitotic agents near the exchangeable nucleotide and vinca alkaloid sites. J.Biol.Chem. 265 17141 PMID: 2211617

Bai et al (1995) Interaction of dolastatin 10 with tubulin: induction of aggregation and binding and dissociation reactions. Mol.Pharmacol. 47 965 PMID: 7746283

Keywords: Dolastatin 10 trifluoroacetate, Dolastatin 10 trifluoroacetate supplier, tubulin, polymerization, inhibitors, inhibits, aggregation, inducers, induces, microtubule, 110417-88-4, Microtubules, Mitosis, 3375, Tocris Bioscience

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Cell Cycle and DNA Damage Research Product Guide

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