Dolastatin 10 trifluoroacetate

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Cat.No. 3375 - Dolastatin 10 trifluoroacetate | C42H68N6O6S.CF3CO2H
Description: Tubulin polymerization inhibitor
Chemical Name: N,N-Dimethyl-L-valyl-N-[(1S,2R)-2-methoxy-4-[(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[[(1S)-2-phenyl-1-(2-thiazol)ethyl]amino]propyl]-1-pyrrolidinyl]-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl--valinamide trifluoroacetate
Purity: ≥95% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Tubulin polymerization inhibitor. Noncompetitively inhibits binding of radiolabeled vincristine to tubulin (Ki = 1.4 μM) and induces tubulin aggregation in vitro.

Technical Data

M. Wt 899.11
Formula C42H68N6O6S.CF3CO2H
Storage Store at -20°C
Purity ≥95% (HPLC)
PubChem ID 9810929
InChI Key OFDNQWIFNXBECV-VFSYNPLYSA-N
Smiles O=C(C[C@@H](OC)[C@@H](N(C)C([C@H](C(C)C)NC([C@@H](N(C)C)C(C)C)=O)=O)[C@@H](C)CC)N1[C@@]([C@H](OC)[C@@H](C)C(N[C@@H](CC3=CC=CC=C3)C2=NC=CS2)=O)([H])CCC1.FC(C(O)=O)(F)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility Soluble in DMSO

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Bai et al (1990) Binding of dolastatin 10 to tubulin at a distinct site for peptide antimitotic agents near the exchangeable nucleotide and vinca alkaloid sites. J.Biol.Chem. 265 17141 PMID: 2211617

Bai et al (1995) Interaction of dolastatin 10 with tubulin: induction of aggregation and binding and dissociation reactions. Mol.Pharmacol. 47 965 PMID: 7746283


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