MLCK inhibitor peptide

Discontinued Product

Unfortunately MLCK inhibitor peptide (Cat. No. 1926) has been withdrawn from sale for commercial reasons.
Cat.No. 1926 - MLCK inhibitor peptide | Lys-Arg-Arg-Trp-Lys-Lys-Asn-Phe-Ile-Ala-Val-NH2 | CAS No. 198694-74-5
Description: Myosin light chain kinase inhibitor
Alternative Names: Myosin Light Chain Kinase Inhibitor
Datasheet
Citations
Literature

Biological Activity

Competitive myosin light chain kinase (MLCK) inhibitor (Ki = 1 - 2.2 mM); derived from the calmodulin binding site of skeletal muscle MLCK. Also inhibits calmodulin.

Technical Data

M. Wt 1444.79
Formula C68H113N23O12
Sequence KRRWKKNFIAV

(Modifications: Val-11 = C-terminal amide)

Storage Desiccate at -20°C
CAS Number 198694-74-5
Smiles [H]N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 1444.79. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.69 mL 3.46 mL 6.92 mL
5 mM 0.14 mL 0.69 mL 1.38 mL
10 mM 0.07 mL 0.35 mL 0.69 mL
50 mM 0.01 mL 0.07 mL 0.14 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Kemp et al (1987) The calmodulin binding domain of chicken smooth muscle myosin light chain kinase contains a pseudosubstrate sequence. J.Biol.Chem. 262 2542 PMID: 3818608

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Citations for MLCK inhibitor peptide

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Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

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Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

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Pathways for MLCK inhibitor peptide

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