MLCK inhibitor peptide

Discontinued Product

Unfortunately MLCK inhibitor peptide (Cat. No. 1926) has been withdrawn from sale for commercial reasons.
Cat.No. 1926 - MLCK inhibitor peptide | Lys-Arg-Arg-Trp-Lys-Lys-Asn-Phe-Ile-Ala-Val-NH2 | CAS No. 198694-74-5
Description: Myosin light chain kinase inhibitor
Alternative Names: Myosin Light Chain Kinase Inhibitor

Biological Activity

Competitive myosin light chain kinase (MLCK) inhibitor (Ki = 1 - 2.2 mM); derived from the calmodulin binding site of skeletal muscle MLCK. Also inhibits calmodulin.

Technical Data

M. Wt 1444.79
Formula C68H113N23O12

(Modifications: Val-11 = C-terminal amide)

Storage Desiccate at -20°C
CAS Number 198694-74-5
Smiles [H]N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 1444.79. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.69 mL 3.46 mL 6.92 mL
5 mM 0.14 mL 0.69 mL 1.38 mL
10 mM 0.07 mL 0.35 mL 0.69 mL
50 mM 0.01 mL 0.07 mL 0.14 mL

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet


References are publications that support the products' biological activity.

Kemp et al (1987) The calmodulin binding domain of chicken smooth muscle myosin light chain kinase contains a pseudosubstrate sequence. J.Biol.Chem. 262 2542 PMID: 3818608

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Citations for MLCK inhibitor peptide

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Currently there are no citations for MLCK inhibitor peptide.

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