Pricing Availability   Qty
Description: Activator of TRPML channels
Chemical Name: 2-[2-(3,4-Dihydro-2,2,4-trimethyl-1(2H)-quinolinyl)-2-oxoethyl]-1H-isoindole-1,3(2H)-dione
Purity: ≥98% (HPLC)
Citations (8)
Literature (2)

Biological Activity for ML SA1

ML SA1 is an activator of TRPML channels (TRPML1, 2 and 3); does not activate TRPM2, TRPV2, TRPV3, TRPC6 or TRPA1 channels. Induces TRPML-mediated Ca2+ release from lysosomes; activity corrects trafficking defects and reduces cholesterol accumulation in Niemann-Pick type C macrophages.

Compound Libraries for ML SA1

ML SA1 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for ML SA1

M. Wt 362.42
Formula C22H22N2O3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 332382-54-4
PubChem ID 2880983
Smiles CC2CC(C)(C)N(C(CN3C(C(C=CC=C4)=C4C3=O)=O)=O)C1=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for ML SA1

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 7.25 20

Preparing Stock Solutions for ML SA1

The following data is based on the product molecular weight 362.42. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 13.8 mL 68.98 mL 137.96 mL
1 mM 2.76 mL 13.8 mL 27.59 mL
2 mM 1.38 mL 6.9 mL 13.8 mL
10 mM 0.28 mL 1.38 mL 2.76 mL

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Product Datasheets for ML SA1

Certificate of Analysis / Product Datasheet
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References for ML SA1

References are publications that support the biological activity of the product.

Shen et al (2012) Lipid storage disorders block lysosomal trafficking by inhibiting TRP channel and calcium release. Nat.Commun. 3 731 PMID: 22415822

Weiss et al (2012) Cross-talk between TRPML1 channel, lipids and lysosomal storage diseases. Commun.Integr.Biol. 5 111 PMID: 22808310

If you know of a relevant reference for ML SA1, please let us know.

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Keywords: ML SA1, ML SA1 supplier, MLSA1, trpml, transient, receptor, potential, channels, mucolipin, TRPML1, TRPML2, TRPML3, lysosomal, lysosome, storage, diseases, TRPML, 4746, Tocris Bioscience

8 Citations for ML SA1

Citations are publications that use Tocris products. Selected citations for ML SA1 include:

Ana-Maria et al (2020) Trpml controls actomyosin contractility and couples migration to phagocytosis in fly macrophages. J Cell Biol 219 PMID: 31940424

Fine et al (2018) Structural basis for PtdInsP2-mediated human TRPML1 regulation. Nat.Commun. 9 4192 PMID: 30305615

Wim et al (2023) Phospholipase D3 degrades mitochondrial DNA to regulate nucleotide signaling and APP metabolism. Nat Commun 14 2847 PMID: 37225734

Wei et al (2021) Berbamine inhibits Japanese encephalitis virus (JEV) infection by compromising TPRMLs-mediated endolysosomal trafficking of low-density lipoprotein receptor (LDLR). Emerg Microbes Infect 10 1257-1271 PMID: 34102949

Do you know of a great paper that uses ML SA1 from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Autophagy Scientific Review

Autophagy Scientific Review

Written by Patricia Boya and Patrice Codogno, this review summarizes the molecular mechanisms, physiology and pathology of autophagy. The role of autophagy in cell death and its links to disease are also discussed. Compounds available from Tocris are listed.

Autophagy Poster

Autophagy Poster

Autophagy is a cellular process used by cells for degradation and recycling. Written by Patricia Boya and Patrice Codogno, this poster summarizes the molecular machinery, physiology and pathology of autophagy. Compounds available from Tocris are listed.