Home / Pharmacology / Ion Channels / Transient Receptor Potential Channels / TRPML Channels / TRPML Channel Activators / ML SA1

ML SA1

Cat. No. 4746 1 Citation Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Activator of TRPML channels
Chemical Name: 2-[2-(3,4-Dihydro-2,2,4-trimethyl-1(2H)-quinolinyl)-2-oxoethyl]-1H-isoindole-1,3(2H)-dione
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for ML SA1

ML SA1 is an activator of TRPML channels (TRPML1, 2 and 3); does not activate TRPM2, TRPV2, TRPV3, TRPC6 or TRPA1 channels. Induces TRPML-mediated Ca2+ release from lysosomes; activity corrects trafficking defects and reduces cholesterol accumulation in Niemann-Pick type C macrophages.

Compound Libraries for ML SA1

ML SA1 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for ML SA1

M. Wt 362.42
Formula C22H22N2O3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 332382-54-4
PubChem ID 2880983
InChI Key KDDHBJICVBONAX-UHFFFAOYSA-N
Smiles CC2CC(C)(C)N(C(CN3C(C(C=CC=C4)=C4C3=O)=O)=O)C1=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for ML SA1

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 7.25 20

Preparing Stock Solutions for ML SA1

The following data is based on the product molecular weight 362.42. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 13.8 mL 68.98 mL 137.96 mL
1 mM 2.76 mL 13.8 mL 27.59 mL
2 mM 1.38 mL 6.9 mL 13.8 mL
10 mM 0.28 mL 1.38 mL 2.76 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets for ML SA1

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet

References for ML SA1

References are publications that support the biological activity of the product.

Shen et al (2012) Lipid storage disorders block lysosomal trafficking by inhibiting TRP channel and calcium release. Nat.Commun. 3 731 PMID: 22415822

Weiss et al (2012) Cross-talk between TRPML1 channel, lipids and lysosomal storage diseases. Commun.Integr.Biol. 5 111 PMID: 22808310

If you know of a relevant reference for ML SA1, please let us know.

View Related Products by Target

View Related Products by Product Action

View all TRPML Channel Activators

Keywords: ML SA1, ML SA1 supplier, MLSA1, trpml, transient, receptor, potential, channels, mucolipin, TRPML1, TRPML2, TRPML3, lysosomal, lysosome, storage, diseases, TRPML, 4746, Tocris Bioscience

1 Citation for ML SA1

Citations are publications that use Tocris products. Selected citations for ML SA1 include:

Fine et al (2018) Structural basis for PtdInsP2-mediated human TRPML1 regulation. Nat.Commun. 9 4192 PMID: 30305615

Do you know of a great paper that uses ML SA1 from Tocris? Please let us know.

Reviews for ML SA1

There are currently no reviews for this product. Be the first to review ML SA1 and earn rewards!

Have you used ML SA1?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Autophagy Scientific Review

Autophagy Scientific Review

Written by Patricia Boya and Patrice Codogno, this review summarizes the molecular mechanisms, physiology and pathology of autophagy. The role of autophagy in cell death and its links to disease are also discussed. Compounds available from Tocris are listed.

Autophagy Poster

Autophagy Poster

Autophagy is a cellular process used by cells for degradation and recycling. Written by Patricia Boya and Patrice Codogno, this poster summarizes the molecular machinery, physiology and pathology of autophagy. Compounds available from Tocris are listed.