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Biological Activity for ML SA1
ML SA1 is an activator of TRPML channels (TRPML1, 2 and 3); does not activate TRPM2, TRPV2, TRPV3, TRPC6 or TRPA1 channels. Induces TRPML-mediated Ca2+ release from lysosomes; activity corrects trafficking defects and reduces cholesterol accumulation in Niemann-Pick type C macrophages.
Compound Libraries for ML SA1
Technical Data for ML SA1
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for ML SA1
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for ML SA1
The following data is based on the product molecular weight 362.42. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||13.8 mL||68.98 mL||137.96 mL|
|1 mM||2.76 mL||13.8 mL||27.59 mL|
|2 mM||1.38 mL||6.9 mL||13.8 mL|
|10 mM||0.28 mL||1.38 mL||2.76 mL|
References for ML SA1
References are publications that support the biological activity of the product.
Shen et al (2012) Lipid storage disorders block lysosomal trafficking by inhibiting TRP channel and calcium release. Nat.Commun. 3 731 PMID: 22415822
Weiss et al (2012) Cross-talk between TRPML1 channel, lipids and lysosomal storage diseases. Commun.Integr.Biol. 5 111 PMID: 22808310
If you know of a relevant reference for ML SA1, please let us know.
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Keywords: ML SA1, ML SA1 supplier, MLSA1, trpml, transient, receptor, potential, channels, mucolipin, TRPML1, TRPML2, TRPML3, lysosomal, lysosome, storage, diseases, TRPML, 4746, Tocris Bioscience
1 Citation for ML SA1
Citations are publications that use Tocris products. Selected citations for ML SA1 include:
Fine et al (2018) Structural basis for PtdInsP2-mediated human TRPML1 regulation. Nat.Commun. 9 4192 PMID: 30305615
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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