ML 402

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Cat.No. 6888 - ML 402 | C14H14ClNO2S | CAS No. 298684-44-3
Description: Selective TREK channel activator
Chemical Name: N-[2-(4-Chloro-2-methylphenoxy)ethyl]-2-thiophenecarboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (5)

Biological Activity

Selective TREK channel activator. Selectively activates K2P2.1 (TREK-1) and K2P10.1 (TREK-2) with no significant effect at K2P4.1 channels (TRAAK).

Technical Data

M. Wt 295.78
Formula C14H14ClNO2S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 298684-44-3
PubChem ID 592973
InChI Key RULQUKFOBAPKKR-UHFFFAOYSA-N
Smiles CC1=C(OCCNC(=O)C2=CC=CS2)C=CC(Cl)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 29.58 100
ethanol 14.79 50

Preparing Stock Solutions

The following data is based on the product molecular weight 295.78. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.38 mL 16.9 mL 33.81 mL
5 mM 0.68 mL 3.38 mL 6.76 mL
10 mM 0.34 mL 1.69 mL 3.38 mL
50 mM 0.07 mL 0.34 mL 0.68 mL

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References

References are publications that support the biological activity of the product.

Lolicato et al (2017) K2P2.1 (TREK-1)-activator complexes reveal a cryptic selectivity filter binding site. Nature 547 364 PMID: 28693035


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Citations for ML 402

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