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ML 402

Cat. No. 6888 Submit a Review Datasheet / COA / SDS

Discontinued Product

6888 has been discontinued.

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Description: Selective TREK channel activator
Chemical Name: N-[2-(4-Chloro-2-methylphenoxy)ethyl]-2-thiophenecarboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations
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Biological Activity Technical Data Datasheets References

Biological Activity for ML 402

ML 402 is a selective TREK channel activator. Selectively activates K2P2.1 (TREK-1) and K2P10.1 (TREK-2) with no significant effect at K2P4.1 channels (TRAAK).

Compound Libraries for ML 402

ML 402 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for ML 402

M. Wt 295.78
Formula C14H14ClNO2S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 298684-44-3
PubChem ID 592973
InChI Key RULQUKFOBAPKKR-UHFFFAOYSA-N
Smiles CC1=C(OCCNC(=O)C2=CC=CS2)C=CC(Cl)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for ML 402

References are publications that support the biological activity of the product.

Lolicato et al (2017) K2P2.1 (TREK-1)-activator complexes reveal a cryptic selectivity filter binding site. Nature 547 364 PMID: 28693035

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Keywords: ML 402, ML 402 supplier, ML402, k2p2.1, 10.1, channels, activators, activates, TREK-1, TREK-2, Two-P, potassium, Potassium, Channels, 6888, Tocris Bioscience

Citations for ML 402

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Currently there are no citations for ML 402.

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