ML 402

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Description: Selective TREK channel activator
Chemical Name: N-[2-(4-Chloro-2-methylphenoxy)ethyl]-2-thiophenecarboxamide
Purity: ≥98% (HPLC)

Biological Activity for ML 402

ML 402 is a selective TREK channel activator. Selectively activates K2P2.1 (TREK-1) and K2P10.1 (TREK-2) with no significant effect at K2P4.1 channels (TRAAK).

Compound Libraries for ML 402

ML 402 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for ML 402

M. Wt 295.78
Formula C14H14ClNO2S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 298684-44-3
PubChem ID 592973
Smiles CC1=C(OCCNC(=O)C2=CC=CS2)C=CC(Cl)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for ML 402

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 29.58 100
ethanol 14.79 50

Preparing Stock Solutions for ML 402

The following data is based on the product molecular weight 295.78. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.38 mL 16.9 mL 33.81 mL
5 mM 0.68 mL 3.38 mL 6.76 mL
10 mM 0.34 mL 1.69 mL 3.38 mL
50 mM 0.07 mL 0.34 mL 0.68 mL

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References for ML 402

References are publications that support the biological activity of the product.

Lolicato et al (2017) K2P2.1 (TREK-1)-activator complexes reveal a cryptic selectivity filter binding site. Nature 547 364 PMID: 28693035

If you know of a relevant reference for ML 402, please let us know.

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Keywords: ML 402, ML 402 supplier, ML402, k2p2.1, 10.1, channels, activators, activates, TREK-1, TREK-2, Two-P, potassium, Potassium, Channels, 6888, Tocris Bioscience

Citations for ML 402

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