Home / Cell Biology / Signal Transduction / Transcription Factors / Nrf2 / Nrf2 Inhibitors / ML 385

ML 385

Cat. No. 6243 2 Citations Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Nrf2 inhibitor; phenotypically lethal
Chemical Name: N-[4-[2,3-Dihydro-1-(2-methylbenzoyl)-1H-indol-5-yl]-5-methyl-2-thiazolyl]-1,3-benzodioxole-5-acetamide
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Reviews
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for ML 385

ML 385 is an Nrf2 inhibitor. Blocks Nrf2 downstream target gene expression. Enhances cytotoxic effects of doxorubicin (Cat. No. 2252) or Taxol (Cat. No. 1097) in non-small cell lung cancer (NSCLC). Demonstrates selectivity for NSCLC cells with KEAP1 mutations.

Compound Libraries for ML 385

ML 385 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for ML 385

M. Wt 511.59
Formula C29H25N3O4S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 846557-71-9
PubChem ID 1383822
InChI Key LINHYWKZVCNAMQ-UHFFFAOYSA-N
Smiles CC1=C(C2=CC=C3N(C(C4=C(C=CC=C4)C)=O)CCC3=C2)N=C(S1)NC(CC5=CC=C6OCOC6=C5)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for ML 385

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 25.58 50

Preparing Stock Solutions for ML 385

The following data is based on the product molecular weight 511.59. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 3.91 mL 19.55 mL 39.09 mL
2.5 mM 0.78 mL 3.91 mL 7.82 mL
5 mM 0.39 mL 1.95 mL 3.91 mL
25 mM 0.08 mL 0.39 mL 0.78 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References for ML 385

References are publications that support the biological activity of the product.

Singh et al (2016) Small molecule inhibitor of NRF2 selectively intervenes therapeutic resistance in KEAP1-deficient NSCLC tumors. ACS Chem.Biol. 11 3214 PMID: 27552339

If you know of a relevant reference for ML 385, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Nrf2 Inhibitors

Keywords: ML 385, ML 385 supplier, ML385, Nrf2, snhibitors, cytotoxic, non-small, cell, lung, cancer, NSCLC, phenotypically, lethal, 6243, Tocris Bioscience

2 Citations for ML 385

Citations are publications that use Tocris products. Selected citations for ML 385 include:

Jeong Hwan et al (2020) Capsosiphon fulvescens Glycoproteins Enhance Probiotics-Induced Cognitive Improvement in Aged Rats. Nutrients 12 PMID: 32245093

Steven C et al (2023) Identifying new biomarkers of aggressive Group 3 and SHH medulloblastoma using 3D hydrogel models, single cell RNA sequencing and 3D OrbiSIMS imaging. Acta Neuropathol Commun 11 6 PMID: 36631900

Do you know of a great paper that uses ML 385 from Tocris? Please let us know.

Reviews for ML 385

There are currently no reviews for this product. Be the first to review ML 385 and earn rewards!

Have you used ML 385?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cancer Metabolism Research Product Guide

Cancer Metabolism Research Product Guide

This product guide reviews some of the main areas in cancer metabolism research and lists around 150 products that can be used to investigate metabolic pathways in cancer including:

Cancer Metabolism Poster

Cancer Metabolism Poster

This poster summarizes the main metabolic pathways in cancer cells and highlights potential targets for cancer therapeutics. Genetic changes and epigenetic modifications in cancer cells alter the regulation of cellular metabolic pathways providing potential cancer therapeutic targets.