ML 385

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Cat.No. 6243 - ML 385 | C29H25N3O4S | CAS No. 846557-71-9
Description: Nrf2 inhibitor; phenotypically lethal
Chemical Name: N-[4-[2,3-Dihydro-1-(2-methylbenzoyl)-1H-indol-5-yl]-5-methyl-2-thiazolyl]-1,3-benzodioxole-5-acetamide
Purity: ≥98% (HPLC)
Reviews (1)
Literature (1)

Biological Activity

Nrf2 inhibitor. Blocks Nrf2 downstream target gene expression. Enhances cytotoxic effects of doxorubicin (Cat. No. 2252) or Taxol (Cat. No. 1097) in non-small cell lung cancer (NSCLC). Demonstrates selectivity for NSCLC cells with KEAP1 mutations.

Compound Libraries

ML 385 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 511.59
Formula C29H25N3O4S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 846557-71-9
PubChem ID 1383822
Smiles CC1=C(C2=CC=C3N(C(C4=C(C=CC=C4)C)=O)CCC3=C2)N=C(S1)NC(CC5=CC=C6OCOC6=C5)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 25.58 50

Preparing Stock Solutions

The following data is based on the product molecular weight 511.59. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 3.91 mL 19.55 mL 39.09 mL
2.5 mM 0.78 mL 3.91 mL 7.82 mL
5 mM 0.39 mL 1.95 mL 3.91 mL
25 mM 0.08 mL 0.39 mL 0.78 mL

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References are publications that support the biological activity of the product.

Singh et al (2016) Small molecule inhibitor of NRF2 selectively intervenes therapeutic resistance in KEAP1-deficient NSCLC tumors. ACS Chem.Biol. 11 3214 PMID: 27552339

If you know of a relevant reference for ML 385, please let us know.

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Citations for ML 385

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Reviews for ML 385

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Inhibition of nrf2 in mouse macrophages.
By Anonymous on 09/24/2019
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: macrophage

Used to inhibit nrf2

Literature in this Area

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