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ML 351 is a selective 12/15 LOX inhibitor (IC50 = 200 nM). Exhibits >250-fold selectivity over related isozymes, 5-LOX, platelet 12-LOX, 15-LOX-2, ovine COX-1, and human COX-2. Protects against oxidative glutamate toxicity in mouse neuronal cells (HT-22) and reduces infarct size in a mouse ischemic stroke model.
ML 351 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 249.27. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.01 mL||20.06 mL||40.12 mL|
|5 mM||0.8 mL||4.01 mL||8.02 mL|
|10 mM||0.4 mL||2.01 mL||4.01 mL|
|50 mM||0.08 mL||0.4 mL||0.8 mL|
References are publications that support the biological activity of the product.
Rai et al (2014) Potent and selective inhibitors of human reticulocyte 12/15-lipoxygenase as anti-stroke therapies. J.Med.Chem. 57 4035 PMID: 24684213
Rai et al (2014) Discovery of ML351, a potent and selective inhibitor of human 15-lipoxygenase-1. Probe Reports from the NIH Molecular Libraries Program PMID: 24672829
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Keywords: ML 351, ML 351 supplier, ML351, Selective, 12/15-lipoxygenase, inhibitors, inhibits, 12/15, LOX, Lipoxygenase, 6448, Tocris Bioscience
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