Selective 12/15 LOX inhibitor (IC50 = 200 nM). Exhibits >250-fold selectivity over related isozymes, 5-LOX, platelet 12-LOX, 15-LOX-2, ovine COX-1, and human COX-2. Protects against oxidative glutamate toxicity in mouse neuronal cells (HT-22) and reduces infarct size in a mouse ischemic stroke model.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 249.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.01 mL||20.06 mL||40.12 mL|
|5 mM||0.8 mL||4.01 mL||8.02 mL|
|10 mM||0.4 mL||2.01 mL||4.01 mL|
|50 mM||0.08 mL||0.4 mL||0.8 mL|
References are publications that support the biological activity of the product.
Rai et al (2014) Potent and selective inhibitors of human reticulocyte 12/15-lipoxygenase as anti-stroke therapies. J.Med.Chem. 57 4035 PMID: 24684213
Rai et al (2014) Discovery of ML351, a potent and selective inhibitor of human 15-lipoxygenase-1. Probe Reports from the NIH Molecular Libraries Program PMID: 24672829
If you know of a relevant reference for ML 351, please let us know.
View Related Products by Product Action
Keywords: ML 351, ML 351 supplier, ML351, Selective, 12/15-lipoxygenase, inhibitors, inhibits, 12/15, LOX, Lipoxygenase, 6448, Tocris Bioscience
Citations for ML 351
Citations are publications that use Tocris products.
Currently there are no citations for ML 351. Do you know of a great paper that uses ML 351 from Tocris? Please let us know.
Reviews for ML 351
There are currently no reviews for this product. Be the first to review ML 351 and earn rewards!
Have you used ML 351?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.