ML 3403

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Description: p38 inhibitor
Chemical Name: [5-[4-(4-Fluorophenyl)-2-methylthio-1H-imidazol-4-yl]-N-(1-phenylethyl)-2-pyridinamine
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (4)
Pathways (1)

Biological Activity for ML 3403

ML 3403 is a p38 MAPK inhibitor (IC50 = 0.38 μM). Inhibits the release of IL-1β and TNF-α in a peripheral blood mononuclear cell (PBMC) assay (IC50 values are 0.039 and 0.16 μM respectively).

Compound Libraries for ML 3403

ML 3403 is also offered as part of the Tocriscreen Kinase Inhibitor Library and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for ML 3403

M. Wt 404.5
Formula C23H21FN4S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 549505-65-9
PubChem ID 6419739
InChI Key VXPWQNBKEIVYIS-UHFFFAOYSA-N
Smiles FC(C=C3)=CC=C3C(N=C(SC)N2)=C2C1=CC=NC(NC(C)C4=CC=CC=C4)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for ML 3403

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 40.45 100
ethanol 20.23 50

Preparing Stock Solutions for ML 3403

The following data is based on the product molecular weight 404.5. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.47 mL 12.36 mL 24.72 mL
5 mM 0.49 mL 2.47 mL 4.94 mL
10 mM 0.25 mL 1.24 mL 2.47 mL
50 mM 0.05 mL 0.25 mL 0.49 mL

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References for ML 3403

References are publications that support the biological activity of the product.

Laufer et al (2003) Novel substituted pyridinyl imidazoles as potent anticytokine agents with low activity against hepatic cytochrome P450 enzymes. J.Med.Chem. 46 3230 PMID: 12852754

Kammerer et al (2007) Pharmacokinetics of ML3403 ({4-[5-(4-fluorophenyl)-2-methylsulfanyl-3H-imidazol-4-yl]-pyridin-2-yl}-(1-phenylethyl)-amine), a 4-pyridinylimidazole-type p38 mitogen-activated protein kinase inhibitor. Drug Metab.Dispos. 35 875 PMID: 17344341


If you know of a relevant reference for ML 3403, please let us know.

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Keywords: ML 3403, ML 3403 supplier, ML3403, p38, MAPK, mitogen-activated, protein, kinase, inhibitors, inhibits, 4586, Tocris Bioscience

Citations for ML 3403

Citations are publications that use Tocris products.

Currently there are no citations for ML 3403. Do you know of a great paper that uses ML 3403 from Tocris? Please let us know.

Reviews for ML 3403

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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MAPK Signaling Scientific Review

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Pathways for ML 3403

MAPK Signaling Pathway

MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.