Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewML 323
Description: Potent and selective USP1-UAF1 allosteric inhibitor
Chemical Name: 5-Methyl-2-[2-(1-methylethyl)phenyl]-N-[[4-(1H-1,2,3-triazol-1-yl)phenyl]methyl]-4-pyrimidinamine
Purity: ≥98% (HPLC)
Biological Activity for ML 323
ML 323 is a potent and selective allosteric inhibitor of USP1-UAF1 deubiquitinase complex (IC50 = 76 nM). Exhibits selectivity for USP1-UAF1 over a panel of enzymes, including other deuquitinating enzymes. Inhibits deubiquitination of PCNA and FANCD2 and sensitizes cisplatin-resistant H596 cells to cell death induced by cisplatin (Cat. No. 2251) in vitro.
Compound Libraries for ML 323
ML 323 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for ML 323
| M. Wt | 384.48 |
| Formula | C23H24N6 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1572414-83-5 |
| PubChem ID | 60167849 |
| InChI Key | VUIRVWPJNKZOSS-UHFFFAOYSA-N |
| Smiles | CC(C)C1=C(C=CC=C1)C1=NC=C(C)C(NCC2=CC=C(C=C2)N2C=CN=N2)=N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for ML 323
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 38.45 | 100 | |
| ethanol | 38.45 | 100 |
Preparing Stock Solutions for ML 323
The following data is based on the product molecular weight 384.48. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.6 mL | 13 mL | 26.01 mL |
| 5 mM | 0.52 mL | 2.6 mL | 5.2 mL |
| 10 mM | 0.26 mL | 1.3 mL | 2.6 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.52 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets for ML 323
References for ML 323
References are publications that support the biological activity of the product.
Liang et al (2014) A selective USP1-UAF1 inhibitor links deubiquitination to DNA damage responses. Nat.Chem.Biol. 10 298 PMID: 24531842
If you know of a relevant reference for ML 323, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: ML 323, ML 323 supplier, ML323, DUB, inhibitors, inhibits, deubiquitinase, USP1, UAF1, potent, selective, Deubiquitinating, Enzymes, 6435, Tocris Bioscience
Citations for ML 323
Citations are publications that use Tocris products.
Currently there are no citations for ML 323. Do you know of a great paper that uses ML 323 from Tocris? Please let us know.
Reviews for ML 323
There are currently no reviews for this product. Be the first to review ML 323 and earn rewards!
Have you used ML 323?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image