Home / Pharmacology / Enzymes / Proteases / Deubiquitinating Enzymes / Deubiquitinating Enzyme Inhibitors / ML 323

ML 323

Cat. No. 6435 Submit a Review Datasheet / COA / SDS
Pricing Availability Delivery Time Qty
Cat.No. 6435 - ML 323 | C23H24N6 | CAS No. 1572414-83-5
Description: Potent and selective USP1-UAF1 allosteric inhibitor
Chemical Name: 5-Methyl-2-[2-(1-methylethyl)phenyl]-N-[[4-(1H-1,2,3-triazol-1-yl)phenyl]methyl]-4-pyrimidinamine
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Potent and selective allosteric inhibitor of USP1-UAF1 deubiquitinase complex (IC50 = 76 nM). Exhibits selectivity for USP1-UAF1 over a panel of enzymes, including other deuquitinating enzymes. Inhibits deubiquitination of PCNA and FANCD2 and sensitizes cisplatin-resistant H596 cells to cell death induced by cisplatin (Cat. No. 2251) in vitro.

Technical Data

M. Wt 384.48
Formula C23H24N6
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1572414-83-5
PubChem ID 60167849
InChI Key VUIRVWPJNKZOSS-UHFFFAOYSA-N
Smiles CC(C)C1=C(C=CC=C1)C1=NC=C(C)C(NCC2=CC=C(C=C2)N2C=CN=N2)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 38.45 100
DMSO 38.45 100

Preparing Stock Solutions

The following data is based on the product molecular weight 384.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.6 mL 13 mL 26.01 mL
5 mM 0.52 mL 2.6 mL 5.2 mL
10 mM 0.26 mL 1.3 mL 2.6 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Certificate of Analysis / Product Datasheet
Safety Datasheet

References

References are publications that support the biological activity of the product.

Liang et al (2014) A selective USP1-UAF1 inhibitor links deubiquitination to DNA damage responses. Nat.Chem.Biol. 10 298 PMID: 24531842

If you know of a relevant reference for ML 323, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Deubiquitinating Enzyme Inhibitors

Keywords: ML 323, ML 323 supplier, ML323, DUB, inhibitors, inhibits, deubiquitinase, USP1, UAF1, potent, selective, Deubiquitinating, Enzymes, 6435, Tocris Bioscience

Citations for ML 323

Citations are publications that use Tocris products.

Currently there are no citations for ML 323. Do you know of a great paper that uses ML 323 from Tocris? Please let us know.

Reviews for ML 323

There are currently no reviews for this product. Be the first to review ML 323 and earn rewards!

Have you used ML 323?

Submit a review and receive an Amazon gift card.

$10US/$10CAN/€7/£6 gift card for a review without an image

$25US/$25CAN/€18/£15 gift card for a review with an image

*Offer only valid in the USA / Canada, UK and Europe

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

New Product Guide

New Product Guide (Spring/Summer 2018)

Our new product guide highlights over 200 new products added to the Tocris Bioscience range during the second half of 2017.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Aptamers
  • Cell Metabolism
  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells