ML 323

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Cat.No. 6435 - ML 323 | C23H24N6 | CAS No. 1572414-83-5
Description: Potent and selective USP1-UAF1 allosteric inhibitor
Chemical Name: 5-Methyl-2-[2-(1-methylethyl)phenyl]-N-[[4-(1H-1,2,3-triazol-1-yl)phenyl]methyl]-4-pyrimidinamine
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent and selective allosteric inhibitor of USP1-UAF1 deubiquitinase complex (IC50 = 76 nM). Exhibits selectivity for USP1-UAF1 over a panel of enzymes, including other deuquitinating enzymes. Inhibits deubiquitination of PCNA and FANCD2 and sensitizes cisplatin-resistant H596 cells to cell death induced by cisplatin (Cat. No. 2251) in vitro.

Technical Data

M. Wt 384.48
Formula C23H24N6
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1572414-83-5
PubChem ID 60167849
InChI Key VUIRVWPJNKZOSS-UHFFFAOYSA-N
Smiles CC(C)C1=C(C=CC=C1)C1=NC=C(C)C(NCC2=CC=C(C=C2)N2C=CN=N2)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 38.45 100
DMSO 38.45 100

Preparing Stock Solutions

The following data is based on the product molecular weight 384.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.6 mL 13 mL 26.01 mL
5 mM 0.52 mL 2.6 mL 5.2 mL
10 mM 0.26 mL 1.3 mL 2.6 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

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References

References are publications that support the biological activity of the product.

Liang et al (2014) A selective USP1-UAF1 inhibitor links deubiquitination to DNA damage responses. Nat.Chem.Biol. 10 298 PMID: 24531842


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