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Biological Activity for ML 281
ML 281 is an inhibitor of the serine/threonine kinase STK33 (IC50 = 14 nM). Exhibits >700-fold selectivity for STK33 over the structurally related protein kinase A (PKA); also exhibits 550-fold selectivity over Aurora kinase B.
Compound Libraries for ML 281
Technical Data for ML 281
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for ML 281
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for ML 281
The following data is based on the product molecular weight 389.47. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.57 mL||12.84 mL||25.68 mL|
|5 mM||0.51 mL||2.57 mL||5.14 mL|
|10 mM||0.26 mL||1.28 mL||2.57 mL|
|50 mM||0.05 mL||0.26 mL||0.51 mL|
References for ML 281
References are publications that support the biological activity of the product.
Weiwer et al (2012) A potent and selective quinoxaline-based STK33 inhibitor does not show synthetic lethality in KRAS-dependent cells. ACS Med.Chem.Lett. 3 1034 PMID: 23256033
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Keywords: ML 281, ML 281 supplier, ML281, STK33, kinases, inhibitors, inhibits, selective, Other, Kinases, 4880, Tocris Bioscience
1 Citation for ML 281
Citations are publications that use Tocris products. Selected citations for ML 281 include:
Christopher J et al (2022) Pharmacologic Targeting of TFIIH Suppresses KRAS-Mutant Pancreatic Ductal Adenocarcinoma and Synergizes with TRAIL. Cancer Res 82 3375-3393 PMID: 35819261
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Reviews for ML 281
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Literature in this Area
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