ML 281

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Cat.No. 4880 - ML 281 | C22H19N3O2S | CAS No. 1404437-62-2
Description: STK33 inhibitor
Chemical Name: N-[2-(3,4-Dihydro-3-oxo-2-quinoxalinyl)-4-(1-methylethyl)phenyl]-2-thiophenecarboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Inhibitor of the serine/threonine kinase STK33 (IC50 = 14 nM). Exhibits >700-fold selectivity for STK33 over the structurally related protein kinase A (PKA); also exhibits 550-fold selectivity over Aurora kinase B.

Compound Libraries

ML 281 is also offered as part of the Tocriscreen Plus and Tocriscreen Kinase Inhibitor Toolbox II. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 389.47
Formula C22H19N3O2S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1404437-62-2
PubChem ID 53377448
InChI Key HWOYIOLMBQSTQS-UHFFFAOYSA-N
Smiles CC(C)C1=CC(C2=NC(C=CC=C3)=C3NC2=O)=C(NC(C4=CC=CS4)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 38.95 100
ethanol 3.89 10mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 389.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.57 mL 12.84 mL 25.68 mL
5 mM 0.51 mL 2.57 mL 5.14 mL
10 mM 0.26 mL 1.28 mL 2.57 mL
50 mM 0.05 mL 0.26 mL 0.51 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Weiwer et al (2012) A potent and selective quinoxaline-based STK33 inhibitor does not show synthetic lethality in KRAS-dependent cells. ACS Med.Chem.Lett. 3 1034 PMID: 23256033


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Keywords: ML 281, supplier, ML281, STK33, kinases, inhibitors, inhibits, selective, Other, Kinases, Other, Kinases, Tocris Bioscience

Citations for ML 281

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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

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Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases

Pathways for ML 281

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