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Biological Activity for ML 202
Potent activator of pyruvate kinase M2 (PKM2) (IC50 = 73 nM). Exhibits little or no activity against the pyruvate kinase isozymes PKM1, PKL and PKR.
Technical Data for ML 202
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References for ML 202
References are publications that support the biological activity of the product.
Boxer et al (2010) Identification of activators for the M2 isoform of human pyruvate kinase version 3. Probe Reports from the Molecular Libraries Program PMID: 21735594
Jiang et al (2010) Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase. Bioorg.Med.Chem.Lett. 20 3387 PMID: 20451379
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Keywords: ML 202, ML 202 supplier, ML202, PKM2, pyruvate, kinases, activators, potent, Other, Kinases, 4859, Tocris Bioscience
Citations for ML 202
Citations are publications that use Tocris products.
Currently there are no citations for ML 202.
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Literature in this Area
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