ML 202
Biological Activity
Potent activator of pyruvate kinase M2 (PKM2) (IC50 = 73 nM). Exhibits little or no activity against the pyruvate kinase isozymes PKM1, PKL and PKR.
Technical Data
| M. Wt | 387.48 |
| Formula | C18H17N3O3S2 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1221186-52-2 |
| PubChem ID | 44246498 |
| InChI Key | MORBXZMIXGYQDB-UHFFFAOYSA-N |
| Smiles | O=C1N(CC4=CC=CC(OC)=C4)N=CC2=C1N(C)C3=C2SC(S(C)=O)=C3 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 38.75 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 387.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.58 mL | 12.9 mL | 25.81 mL |
| 5 mM | 0.52 mL | 2.58 mL | 5.16 mL |
| 10 mM | 0.26 mL | 1.29 mL | 2.58 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.52 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Boxer et al (2010) Identification of activators for the M2 isoform of human pyruvate kinase version 3. Probe Reports from the Molecular Libraries Program PMID: 21735594
Jiang et al (2010) Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase. Bioorg.Med.Chem.Lett. 20 3387 PMID: 20451379
If you know of a relevant reference for ML 202, please let us know.
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Keywords: ML202 PKM2 pyruvate kinases activators potent Other Kinases
Citations for ML 202
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