ML 202

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Cat.No. 4859 - ML 202 | C18H17N3O3S2 | CAS No. 1221186-52-2
Description: Pyruvate kinase M2 activator
Chemical Name: 4,6-Dihydro-6-[(3-methoxyphenyl)methyl]-4-methyl-2-(methylsulfinyl)-5H-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-one
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent activator of pyruvate kinase M2 (PKM2) (IC50 = 73 nM). Exhibits little or no activity against the pyruvate kinase isozymes PKM1, PKL and PKR.

Technical Data

M. Wt 387.48
Formula C18H17N3O3S2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1221186-52-2
PubChem ID 44246498
InChI Key MORBXZMIXGYQDB-UHFFFAOYSA-N
Smiles O=C1N(CC4=CC=CC(OC)=C4)N=CC2=C1N(C)C3=C2SC(S(C)=O)=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 38.75 100

Preparing Stock Solutions

The following data is based on the product molecular weight 387.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.58 mL 12.9 mL 25.81 mL
5 mM 0.52 mL 2.58 mL 5.16 mL
10 mM 0.26 mL 1.29 mL 2.58 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

Molarity Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Boxer et al (2010) Identification of activators for the M2 isoform of human pyruvate kinase version 3. Probe Reports from the Molecular Libraries Program PMID: 21735594

Jiang et al (2010) Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase. Bioorg.Med.Chem.Lett. 20 3387 PMID: 20451379


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Keywords: ML202 PKM2 pyruvate kinases activators potent Other Kinases

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