Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewML 202
Description: Pyruvate kinase M2 activator
Chemical Name: 4,6-Dihydro-6-[(3-methoxyphenyl)methyl]-4-methyl-2-(methylsulfinyl)-5H-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-one
Purity: ≥98% (HPLC)
Biological Activity for ML 202
Potent activator of pyruvate kinase M2 (PKM2) (IC50 = 73 nM). Exhibits little or no activity against the pyruvate kinase isozymes PKM1, PKL and PKR.
Technical Data for ML 202
| M. Wt | 387.48 |
| Formula | C18H17N3O3S2 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1221186-52-2 |
| PubChem ID | 44246498 |
| InChI Key | MORBXZMIXGYQDB-UHFFFAOYSA-N |
| Smiles | O=C1N(CC4=CC=CC(OC)=C4)N=CC2=C1N(C)C3=C2SC(S(C)=O)=C3 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for ML 202
References for ML 202
References are publications that support the biological activity of the product.
Boxer et al (2010) Identification of activators for the M2 isoform of human pyruvate kinase version 3. Probe Reports from the Molecular Libraries Program PMID: 21735594
Jiang et al (2010) Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase. Bioorg.Med.Chem.Lett. 20 3387 PMID: 20451379
View Related Products by Target
View Related Products by Product Action
Keywords: ML 202, ML 202 supplier, ML202, PKM2, pyruvate, kinases, activators, potent, Other, Kinases, 4859, Tocris Bioscience
Citations for ML 202
Citations are publications that use Tocris products.
Currently there are no citations for ML 202.
Reviews for ML 202
There are currently no reviews for this product. Be the first to review ML 202 and earn rewards!
Have you used ML 202?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image