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Mitochondrial fusion promoter M1 is a mitochondrial fusion promoter. Protects cells from mitochondrial fragmentation-associated cell death. Induces mitochondrial fusion in effector T cells imposing a memory T cell morphology. Improves cellular respiration and potentiates glucose-stimulated insulin-secretion in cholesterol-exposed pancreatic β cells. Mitochondrial fusion promoter M1 also enhances mitochondrial dynamics and transport velocity in axons of the sciatic nerve in vitro and enhances axon regeneration in the optic nerve in an in vivo model of nerve damage.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 364.05. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.75 mL||13.73 mL||27.47 mL|
|5 mM||0.55 mL||2.75 mL||5.49 mL|
|10 mM||0.27 mL||1.37 mL||2.75 mL|
|50 mM||0.05 mL||0.27 mL||0.55 mL|
References are publications that support the biological activity of the product.
Asalla et al (2016) Restoring mitochondrial function: a small molecule-mediated approach to enhance glucose stimulated insulin secretion in cholesterol accumulated pancreatic beta cells. Sci.Rep. 10 27513 PMID: 27282931
Wang et al (2012) A small molecule promotes mitochondrial fusion in mammalian cells. Angew.Chem.Int.Ed.Engl. 51 9302 PMID: 22907892
Buck et al (2016) Mitochondrial dynamics controls T cell fate through metabolic programming. Cell 166 63 PMID: 27293185
Au et al (2022) A small molecule M1 promotes optic nerve regeneration to restore target-specific neural activity and visual function. Proc.Natl.Acad.Sci.USA 119 e2121273119 PMID: 36306327
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Keywords: Mitochondrial fusion promoter M1, Mitochondrial fusion promoter M1 supplier, mitochondrial, fusion, promoters, promotes, cellular, respiration, mitochondrion, Oxidative, Phosphorylation, Other, Apoptosis, 6898, Tocris Bioscience
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