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Mitochondrial fusion promoter M1

Cat. No. 6898 Submit a Review Datasheet / COA / SDS
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Description: Mitochondrial fusion promoter
Chemical Name: 4-Chloro-2-(1-(2-(2,4,6-trichlorophenyl)hydrazono)ethyl)phenol
Purity: ≥98% (HPLC)
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Biological Activity for Mitochondrial fusion promoter M1

Mitochondrial fusion promoter M1 is a mitochondrial fusion promoter. Protects cells from mitochondrial fragmentation-associated cell death. Induces mitochondrial fusion in effector T cells imposing a memory T cell morphology. Improves cellular respiration and potentiates glucose-stimulated insulin-secretion in cholesterol-exposed pancreatic β cells. Mitochondrial fusion promoter M1 also enhances mitochondrial dynamics and transport velocity in axons of the sciatic nerve in vitro and enhances axon regeneration in the optic nerve in an in vivo model of nerve damage.

Technical Data for Mitochondrial fusion promoter M1

M. Wt 364.05
Formula C14H10Cl4N2O
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 219315-22-7
PubChem ID 136672588
InChI Key CYVDGZYJHHYIIU-GXHLCREISA-N
Smiles C\C(=N/NC1=C(Cl)C=C(Cl)C=C1Cl)C1=C(O)C=CC(Cl)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Mitochondrial fusion promoter M1

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.41 100

Preparing Stock Solutions for Mitochondrial fusion promoter M1

The following data is based on the product molecular weight 364.05. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.75 mL 13.73 mL 27.47 mL
5 mM 0.55 mL 2.75 mL 5.49 mL
10 mM 0.27 mL 1.37 mL 2.75 mL
50 mM 0.05 mL 0.27 mL 0.55 mL

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Product Datasheets for Mitochondrial fusion promoter M1

Certificate of Analysis / Product Datasheet
Safety Datasheet

References for Mitochondrial fusion promoter M1

References are publications that support the biological activity of the product.

Asalla et al (2016) Restoring mitochondrial function: a small molecule-mediated approach to enhance glucose stimulated insulin secretion in cholesterol accumulated pancreatic beta cells. Sci.Rep. 10 27513 PMID: 27282931

Wang et al (2012) A small molecule promotes mitochondrial fusion in mammalian cells. Angew.Chem.Int.Ed.Engl. 51 9302 PMID: 22907892

Buck et al (2016) Mitochondrial dynamics controls T cell fate through metabolic programming. Cell 166 63 PMID: 27293185

Au et al (2022) A small molecule M1 promotes optic nerve regeneration to restore target-specific neural activity and visual function. Proc.Natl.Acad.Sci.USA 119 e2121273119 PMID: 36306327

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Citations for Mitochondrial fusion promoter M1

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