Mitochondrial fusion promoter M1

Discontinued Product

Mitochondrial fusion promoter M1 (Cat. No. 6898) has been withdrawn from sale for commercial reasons.
Description: Mitochondrial fusion promoter
Chemical Name: 4-Chloro-2-(1-(2-(2,4,6-trichlorophenyl)hydrazono)ethyl)phenol
Purity: ≥98% (HPLC)
Citations (1)
Literature (1)

Biological Activity for Mitochondrial fusion promoter M1

Mitochondrial fusion promoter M1 is a mitochondrial fusion promoter. Protects cells from mitochondrial fragmentation-associated cell death. Induces mitochondrial fusion in effector T cells imposing a memory T cell morphology. Improves cellular respiration and potentiates glucose-stimulated insulin-secretion in cholesterol-exposed pancreatic β cells. Mitochondrial fusion promoter M1 also enhances mitochondrial dynamics and transport velocity in axons of the sciatic nerve in vitro and enhances axon regeneration in the optic nerve in an in vivo model of nerve damage.

Technical Data for Mitochondrial fusion promoter M1

M. Wt 364.05
Formula C14H10Cl4N2O
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 219315-22-7
PubChem ID 136672588
Smiles C\C(=N/NC1=C(Cl)C=C(Cl)C=C1Cl)C1=C(O)C=CC(Cl)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Mitochondrial fusion promoter M1

References for Mitochondrial fusion promoter M1

References are publications that support the biological activity of the product.

Asalla et al (2016) Restoring mitochondrial function: a small molecule-mediated approach to enhance glucose stimulated insulin secretion in cholesterol accumulated pancreatic beta cells. Sci.Rep. 10 27513 PMID: 27282931

Wang et al (2012) A small molecule promotes mitochondrial fusion in mammalian cells. Angew.Chem.Int.Ed.Engl. 51 9302 PMID: 22907892

Buck et al (2016) Mitochondrial dynamics controls T cell fate through metabolic programming. Cell 166 63 PMID: 27293185

Au et al (2022) A small molecule M1 promotes optic nerve regeneration to restore target-specific neural activity and visual function. Proc.Natl.Acad.Sci.USA 119 e2121273119 PMID: 36306327

Keywords: Mitochondrial fusion promoter M1, Mitochondrial fusion promoter M1 supplier, mitochondrial, fusion, promoters, promotes, cellular, respiration, mitochondrion, Oxidative, Phosphorylation, Other, Apoptosis, 6898, Tocris Bioscience

1 Citation for Mitochondrial fusion promoter M1

Citations are publications that use Tocris products. Selected citations for Mitochondrial fusion promoter M1 include:

Dan et al (2022) Aspartate Alleviates Colonic Epithelial Damage by Regulating Intestinal Stem Cell Proliferation and Differentiation via Mitochondrial Dynamics. Mol Nutr Food Res 66 e2200168 PMID: 36310136

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Literature in this Area

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