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Discontinued Product(-)-Lobeline hydrochloride (Cat. No. 1077) has been withdrawn from sale for commercial reasons.
Biological Activity for (-)-Lobeline hydrochloride
(-)-Lobeline hydrochloride is a high affinity, partial agonist with a Ki value of 4.4 nM in rat brain.
Technical Data for (-)-Lobeline hydrochloride
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for (-)-Lobeline hydrochloride
References for (-)-Lobeline hydrochloride
References are publications that support the biological activity of the product.
Damaj et al (1997) Pharmacology of lobeline, a nicotinic receptor ligand. J.Pharmacol.Exp.Ther. 282 410 PMID: 9223582
Merck Index 12 5580
Farook et al (2009) Lobeline, a nicotinic partial agonist attenuates alcohol consumption and preference in male C57BL/6J mice. Physiol.Behav. 97 503 PMID: 19268674
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Keywords: (-)-Lobeline hydrochloride, (-)-Lobeline hydrochloride supplier, Nicotinic, agonists, Acetylcholine, Receptors, Non-Selective, Subtypes, nAChR, partial, (Non-selective), 1077, Tocris Bioscience
Citations for (-)-Lobeline hydrochloride
Citations are publications that use Tocris products.
Currently there are no citations for (-)-Lobeline hydrochloride.
Reviews for (-)-Lobeline hydrochloride
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.