(-)-Lobeline hydrochloride

Discontinued Product

(-)-Lobeline hydrochloride (Cat. No. 1077) has been withdrawn from sale for commercial reasons.
Description: Nicotinic partial agonist
Chemical Name: 2-[(2R,6S)-6-[(2S)-2-Hydroxyphenethyl)]-1-methyl-2-piperidinyl]acetophenone hydrochloride
Literature (1)

Biological Activity for (-)-Lobeline hydrochloride

(-)-Lobeline hydrochloride is a high affinity, partial agonist with a Ki value of 4.4 nM in rat brain.

Technical Data for (-)-Lobeline hydrochloride

M. Wt 373.92
Formula C22H27NO2.HCl
Storage Store at RT
CAS Number 134-63-4
PubChem ID 11527152
Smiles O[C@H]([C@]2=CC=CC=C2)C[C@@H]1CCC[C@H](CC(C3=CC=CC=C3)=O)N1C.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for (-)-Lobeline hydrochloride

Certificate of Analysis / Product Datasheet
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References for (-)-Lobeline hydrochloride

References are publications that support the biological activity of the product.

Damaj et al (1997) Pharmacology of lobeline, a nicotinic receptor ligand. J.Pharmacol.Exp.Ther. 282 410 PMID: 9223582

Merck Index 12 5580

Farook et al (2009) Lobeline, a nicotinic partial agonist attenuates alcohol consumption and preference in male C57BL/6J mice. Physiol.Behav. 97 503 PMID: 19268674

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Keywords: (-)-Lobeline hydrochloride, (-)-Lobeline hydrochloride supplier, Nicotinic, agonists, Acetylcholine, Receptors, Non-Selective, Subtypes, nAChR, partial, (Non-selective), 1077, Tocris Bioscience

Citations for (-)-Lobeline hydrochloride

Citations are publications that use Tocris products.

Currently there are no citations for (-)-Lobeline hydrochloride.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Nicotinic ACh Receptors Scientific Review

Nicotinic ACh Receptors Scientific Review

Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.