(-)-Lobeline hydrochloride

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Cat.No. 1077 - (-)-Lobeline hydrochloride | C22H27NO2.HCl | CAS No. 134-63-4
Description: Nicotinic partial agonist
Chemical Name: 2-[(2R,6S)-6-[(2S)-2-Hydroxyphenethyl)]-1-methyl-2-piperidinyl]acetophenone hydrochloride
Datasheet
Citations
Literature

Biological Activity

High affinity, partial agonist with a Ki value of 4.4 nM in rat brain.

Technical Data

M. Wt 373.92
Formula C22H27NO2.HCl
Storage Store at RT
CAS Number 134-63-4
PubChem ID 11527152
InChI Key LPMXVESGRSUGHW-VGFRVVOQSA-N
Smiles O[C@H]([C@]2=CC=CC=C2)C[C@@H]1CCC[C@H](CC(C3=CC=CC=C3)=O)N1C.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 50 mM in ethanol and to 10 mM in water

Preparing Stock Solutions

The following data is based on the product molecular weight 373.92. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.67 mL 13.37 mL 26.74 mL
5 mM 0.53 mL 2.67 mL 5.35 mL
10 mM 0.27 mL 1.34 mL 2.67 mL
50 mM 0.05 mL 0.27 mL 0.53 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Damaj et al (1997) Pharmacology of lobeline, a nicotinic receptor ligand. J.Pharmacol.Exp.Ther. 282 410 PMID: 9223582

Merck Index 12 5580 PMID:

Farook et al (2009) Lobeline, a nicotinic partial agonist attenuates alcohol consumption and preference in male C57BL/6J mice. Physiol.Behav. 97 503 PMID: 19268674


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Keywords: Nicotinic agonists Acetylcholine Receptors Non-Selective Subtypes nAChR partial Nicotinic Receptors (Non-selective)

Citations for (-)-Lobeline hydrochloride

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Literature in this Area

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Pain Research Product Guide

A collection of over 250 products for pain research, the guide includes research tools for the study of:

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Nicotinic ACh Receptors Scientific Review

Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.

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Pain Poster

Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.

Pathways for (-)-Lobeline hydrochloride

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