(-)-Lobeline hydrochloride

Pricing Availability   Qty
Cat.No. 1077 - (-)-Lobeline hydrochloride | C22H27NO2.HCl | CAS No. 134-63-4
Description: Nicotinic partial agonist
Chemical Name: 2-[(2R,6S)-6-[(2S)-2-Hydroxyphenethyl)]-1-methyl-2-piperidinyl]acetophenone hydrochloride
Datasheet
Citations
Reviews
Literature (3)

Biological Activity

High affinity, partial agonist with a Ki value of 4.4 nM in rat brain.

Technical Data

M. Wt 373.92
Formula C22H27NO2.HCl
Storage Store at RT
CAS Number 134-63-4
PubChem ID 11527152
InChI Key LPMXVESGRSUGHW-VGFRVVOQSA-N
Smiles O[C@H]([C@]2=CC=CC=C2)C[C@@H]1CCC[C@H](CC(C3=CC=CC=C3)=O)N1C.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 50 mM in ethanol and to 10 mM in water

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:

References

References are publications that support the biological activity of the product.

Damaj et al (1997) Pharmacology of lobeline, a nicotinic receptor ligand. J.Pharmacol.Exp.Ther. 282 410 PMID: 9223582

Merck Index 12 5580

Farook et al (2009) Lobeline, a nicotinic partial agonist attenuates alcohol consumption and preference in male C57BL/6J mice. Physiol.Behav. 97 503 PMID: 19268674


If you know of a relevant reference for (-)-Lobeline hydrochloride, please let us know.

View Related Products by Product Action

View all Nicotinic Receptor (Non-selective) Agonists

Keywords: (-)-Lobeline hydrochloride, (-)-Lobeline hydrochloride supplier, Nicotinic, agonists, Acetylcholine, Receptors, Non-Selective, Subtypes, nAChR, partial, (Non-selective), 1077, Tocris Bioscience

Citations for (-)-Lobeline hydrochloride

Citations are publications that use Tocris products.

Currently there are no citations for (-)-Lobeline hydrochloride. Do you know of a great paper that uses (-)-Lobeline hydrochloride from Tocris? Please let us know.

Reviews for (-)-Lobeline hydrochloride

There are currently no reviews for this product. Be the first to review (-)-Lobeline hydrochloride and earn rewards!

Have you used (-)-Lobeline hydrochloride?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Pain

Pain Research Product Guide

A collection of over 280 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling
Nicotinic ACh Receptors

Nicotinic ACh Receptors Scientific Review

Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.

Pain

Pain Poster

Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.