(-)-Lobeline hydrochloride

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Cat.No. 1077 - (-)-Lobeline hydrochloride | C22H27NO2.HCl | CAS No. 134-63-4
Description: Nicotinic partial agonist
Chemical Name: 2-[(2R,6S)-6-[(2S)-2-Hydroxyphenethyl)]-1-methyl-2-piperidinyl]acetophenone hydrochloride

Biological Activity

High affinity, partial agonist with a Ki value of 4.4 nM in rat brain.

Technical Data

M. Wt 373.92
Formula C22H27NO2.HCl
Storage Store at RT
CAS Number 134-63-4
PubChem ID 11527152
Smiles O[C@H]([C@]2=CC=CC=C2)C[C@@H]1CCC[C@H](CC(C3=CC=CC=C3)=O)N1C.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 50 mM in ethanol and to 10 mM in water

Preparing Stock Solutions

The following data is based on the product molecular weight 373.92. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.67 mL 13.37 mL 26.74 mL
5 mM 0.53 mL 2.67 mL 5.35 mL
10 mM 0.27 mL 1.34 mL 2.67 mL
50 mM 0.05 mL 0.27 mL 0.53 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet


References are publications that support the products' biological activity.

Damaj et al (1997) Pharmacology of lobeline, a nicotinic receptor ligand. J.Pharmacol.Exp.Ther. 282 410 PMID: 9223582

Merck Index 12 5580 PMID:

Farook et al (2009) Lobeline, a nicotinic partial agonist attenuates alcohol consumption and preference in male C57BL/6J mice. Physiol.Behav. 97 503 PMID: 19268674

If you know of a relevant reference for (-)-Lobeline hydrochloride, please let us know.

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Keywords: (-)-Lobeline hydrochloride, supplier, Nicotinic, agonists, Acetylcholine, Receptors, Non-Selective, Subtypes, nAChR, partial, Nicotinic, Receptors, (Non-selective), Nicotinic, Receptors, (Non-selective), Tocris Bioscience

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