(-)-Lobeline hydrochloride

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Cat.No. 1077 - (-)-Lobeline hydrochloride | C22H27NO2.HCl | CAS No. 134-63-4
Description: Nicotinic partial agonist
Chemical Name: 2-[(2R,6S)-6-[(2S)-2-Hydroxyphenethyl)]-1-methyl-2-piperidinyl]acetophenone hydrochloride
Literature (3)

Biological Activity

High affinity, partial agonist with a Ki value of 4.4 nM in rat brain.

Technical Data

M. Wt 373.92
Formula C22H27NO2.HCl
Storage Store at RT
CAS Number 134-63-4
PubChem ID 11527152
Smiles O[C@H]([C@]2=CC=CC=C2)C[C@@H]1CCC[C@H](CC(C3=CC=CC=C3)=O)N1C.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
ethanol 50
water 10

Preparing Stock Solutions

The following data is based on the product molecular weight 373.92. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.35 mL 26.74 mL 53.49 mL
2.5 mM 1.07 mL 5.35 mL 10.7 mL
5 mM 0.53 mL 2.67 mL 5.35 mL
25 mM 0.11 mL 0.53 mL 1.07 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the biological activity of the product.

Damaj et al (1997) Pharmacology of lobeline, a nicotinic receptor ligand. J.Pharmacol.Exp.Ther. 282 410 PMID: 9223582

Merck Index 12 5580

Farook et al (2009) Lobeline, a nicotinic partial agonist attenuates alcohol consumption and preference in male C57BL/6J mice. Physiol.Behav. 97 503 PMID: 19268674

If you know of a relevant reference for (-)-Lobeline hydrochloride, please let us know.

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Citations for (-)-Lobeline hydrochloride

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