High affinity, partial agonist with a Ki value of 4.4 nM in rat brain.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 50 mM in ethanol and to 10 mM in water|
Preparing Stock Solutions
The following data is based on the product molecular weight 373.92. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.67 mL||13.37 mL||26.74 mL|
|5 mM||0.53 mL||2.67 mL||5.35 mL|
|10 mM||0.27 mL||1.34 mL||2.67 mL|
|50 mM||0.05 mL||0.27 mL||0.53 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Damaj et al (1997) Pharmacology of lobeline, a nicotinic receptor ligand. J.Pharmacol.Exp.Ther. 282 410 PMID: 9223582
Farook et al (2009) Lobeline, a nicotinic partial agonist attenuates alcohol consumption and preference in male C57BL/6J mice. Physiol.Behav. 97 503 PMID: 19268674
If you know of a relevant reference for (-)-Lobeline hydrochloride, please let us know.
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Keywords: Nicotinic agonists Acetylcholine Receptors Non-Selective Subtypes nAChR partial Nicotinic Receptors (Non-selective)
Citations for (-)-Lobeline hydrochloride
Citations are publications that use Tocris products.
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Literature in this Area
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.