(-)-Cytisine

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Cat.No. 1390 - (-)-Cytisine | C11H14N2O | CAS No. 485-35-8
Description: Potent, selective neuronal nicotinic agonist
Chemical Name: (1R,5S)-1,2,3,4,5,6-hexahydro-1,5-methano-8H-pyrido[1,2-a][1,5]diazocin-8-one
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

A potent, selective agonist at neuronal nicotinic receptors. Acts as a partial agonist at β2-containing nicotinic receptors.

Technical Data

M. Wt 190.24
Formula C11H14N2O
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 485-35-8
PubChem ID 10235
InChI Key ANJTVLIZGCUXLD-DTWKUNHWSA-N
Smiles O=C2N1C[C@@]([H])(C3)CNC[C@@]([H])3C1=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 100 mM in water

Preparing Stock Solutions

The following data is based on the product molecular weight 190.24. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.26 mL 26.28 mL 52.57 mL
5 mM 1.05 mL 5.26 mL 10.51 mL
10 mM 0.53 mL 2.63 mL 5.26 mL
50 mM 0.11 mL 0.53 mL 1.05 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Happe et al (1994) Localization of nicotinic cholinergic receptors in rat brain: autoradiographic studies with [3H]cytisine. Neuroscience 62 929 PMID: 7870314

Papke et al (1994) Partial agonist properties of cytisine on neuronal nicotinic receptors containing the β2 subunit. Mol.Pharmacol. 45 142 PMID: 8302273

Reavill et al (1990) Behavioural and pharmacokinetic studies on nicotine, cytisine and lobeline. Neuropharmacology 29 619 PMID: 2385332


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Keywords: (-)-Cytisine, supplier, Potent, selective, neuronal, nicotinic, agonists, Acetylcholine, Receptors, Non-Selective, Subtypes, nAChR, Nicotinic, Receptors, (Non-selective), Nicotinic, Receptors, (Non-selective), Tocris Bioscience

1 Citation for (-)-Cytisine

Citations are publications that use Tocris products. Selected citations for (-)-Cytisine include:

Li et al (2010) Cytisine induces autonomic cardiovascular responses via activations of different nicotinic receptors. Auton Neurosci 154 14 PMID: 19887306


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