Pricing Availability   Qty
Cat.No. 1390 - (-)-Cytisine | C11H14N2O | CAS No. 485-35-8
Description: Potent and selective neuronal nAChRagonist
Chemical Name: (1R,5S)-1,2,3,4,5,6-hexahydro-1,5-methano-8H-pyrido[1,2-a][1,5]diazocin-8-one
Purity: ≥99% (HPLC)
Citations (2)
Literature (3)

Biological Activity

A potent, selective agonist at neuronal nicotinic receptors. Acts as a partial agonist at β2-containing nicotinic receptors.

Technical Data

M. Wt 190.24
Formula C11H14N2O
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 485-35-8
PubChem ID 10235
Smiles O=C2N1C[C@@]([H])(C3)CNC[C@@]([H])3C1=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 100 mM in water

Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the biological activity of the product.

Happe et al (1994) Localization of nicotinic cholinergic receptors in rat brain: autoradiographic studies with [3H]cytisine. Neuroscience 62 929 PMID: 7870314

Papke et al (1994) Partial agonist properties of cytisine on neuronal nicotinic receptors containing the β2 subunit. Mol.Pharmacol. 45 142 PMID: 8302273

Reavill et al (1990) Behavioural and pharmacokinetic studies on nicotine, cytisine and lobeline. Neuropharmacology 29 619 PMID: 2385332

If you know of a relevant reference for (-)-Cytisine, please let us know.

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Keywords: (-)-Cytisine, (-)-Cytisine supplier, Potent, selective, neuronal, nicotinic, agonists, Acetylcholine, Receptors, Non-Selective, Subtypes, nAChR, Nicotinic, (Non-selective), 1390, Tocris Bioscience

2 Citations for (-)-Cytisine

Citations are publications that use Tocris products. Selected citations for (-)-Cytisine include:

Li et al (2010) Cytisine induces autonomic cardiovascular responses via activations of different nicotinic receptors. Auton Neurosci 154 14 PMID: 19887306

David et al (2010) Biochemical and functional properties of distinct nicotinic acetylcholine receptors in the superior cervical ganglion of mice with targeted deletions of nAChR subunit genes. Eur J Neurosci 31 978 PMID: 20377613

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Pain Research Product Guide

A collection of over 280 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling
Nicotinic ACh Receptors

Nicotinic ACh Receptors Scientific Review

Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.


Pain Poster

Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.