Pricing Availability   Qty
Description: Potent and selective neuronal nAChRagonist
Chemical Name: (1R,5S)-1,2,3,4,5,6-hexahydro-1,5-methano-8H-pyrido[1,2-a][1,5]diazocin-8-one
Purity: ≥99% (HPLC)
Citations (2)
Literature (1)

Biological Activity for (-)-Cytisine

(-)-Cytisine is a potent, selective agonist at neuronal nicotinic receptors. Acts as a partial agonist at β2-containing nicotinic receptors.

Technical Data for (-)-Cytisine

M. Wt 190.24
Formula C11H14N2O
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 485-35-8
PubChem ID 10235
Smiles O=C2N1C[C@@]([H])(C3)CNC[C@@]([H])3C1=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for (-)-Cytisine

Solvent Max Conc. mg/mL Max Conc. mM
water 100

Preparing Stock Solutions for (-)-Cytisine

The following data is based on the product molecular weight 190.24. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.26 mL 26.28 mL 52.57 mL
5 mM 1.05 mL 5.26 mL 10.51 mL
10 mM 0.53 mL 2.63 mL 5.26 mL
50 mM 0.11 mL 0.53 mL 1.05 mL

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Product Datasheets for (-)-Cytisine

Certificate of Analysis / Product Datasheet
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References for (-)-Cytisine

References are publications that support the biological activity of the product.

Happe et al (1994) Localization of nicotinic cholinergic receptors in rat brain: autoradiographic studies with [3H]cytisine. Neuroscience 62 929 PMID: 7870314

Papke et al (1994) Partial agonist properties of cytisine on neuronal nicotinic receptors containing the β2 subunit. Mol.Pharmacol. 45 142 PMID: 8302273

Reavill et al (1990) Behavioural and pharmacokinetic studies on nicotine, cytisine and lobeline. Neuropharmacology 29 619 PMID: 2385332

If you know of a relevant reference for (-)-Cytisine, please let us know.

View Related Products by Product Action

View all Nicotinic Receptor (Non-selective) Agonists

Keywords: (-)-Cytisine, (-)-Cytisine supplier, Potent, selective, neuronal, nicotinic, agonists, Acetylcholine, Receptors, Non-Selective, Subtypes, nAChR, Nicotinic, (Non-selective), 1390, Tocris Bioscience

2 Citations for (-)-Cytisine

Citations are publications that use Tocris products. Selected citations for (-)-Cytisine include:

David et al (2010) Biochemical and functional properties of distinct nicotinic acetylcholine receptors in the superior cervical ganglion of mice with targeted deletions of nAChR subunit genes. Eur J Neurosci 31 978 PMID: 20377613

Li et al (2010) Cytisine induces autonomic cardiovascular responses via activations of different nicotinic receptors. Auton Neurosci 154 14 PMID: 19887306

Do you know of a great paper that uses (-)-Cytisine from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Nicotinic ACh Receptors Scientific Review

Nicotinic ACh Receptors Scientific Review

Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.