Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit Review(-)-Cytisine is a potent, selective agonist at neuronal nicotinic receptors. Acts as a partial agonist at β2-containing nicotinic receptors.
M. Wt | 190.24 |
Formula | C11H14N2O |
Storage | Desiccate at RT |
Purity | ≥99% (HPLC) |
CAS Number | 485-35-8 |
PubChem ID | 10235 |
InChI Key | ANJTVLIZGCUXLD-DTWKUNHWSA-N |
Smiles | O=C2N1C[C@@]([H])(C3)CNC[C@@]([H])3C1=CC=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solvent | Max Conc. mg/mL | Max Conc. mM | |
---|---|---|---|
Solubility | |||
water | 100 |
The following data is based on the product molecular weight 190.24. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 5.26 mL | 26.28 mL | 52.57 mL |
5 mM | 1.05 mL | 5.26 mL | 10.51 mL |
10 mM | 0.53 mL | 2.63 mL | 5.26 mL |
50 mM | 0.11 mL | 0.53 mL | 1.05 mL |
References are publications that support the biological activity of the product.
Happe et al (1994) Localization of nicotinic cholinergic receptors in rat brain: autoradiographic studies with [3H]cytisine. Neuroscience 62 929 PMID: 7870314
Papke et al (1994) Partial agonist properties of cytisine on neuronal nicotinic receptors containing the β2 subunit. Mol.Pharmacol. 45 142 PMID: 8302273
Reavill et al (1990) Behavioural and pharmacokinetic studies on nicotine, cytisine and lobeline. Neuropharmacology 29 619 PMID: 2385332
If you know of a relevant reference for (-)-Cytisine, please let us know.
Keywords: (-)-Cytisine, (-)-Cytisine supplier, Potent, selective, neuronal, nicotinic, agonists, Acetylcholine, Receptors, Non-Selective, Subtypes, nAChR, Nicotinic, (Non-selective), 1390, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for (-)-Cytisine include:
Li et al (2010) Cytisine induces autonomic cardiovascular responses via activations of different nicotinic receptors. Auton Neurosci 154 14 PMID: 19887306
David et al (2010) Biochemical and functional properties of distinct nicotinic acetylcholine receptors in the superior cervical ganglion of mice with targeted deletions of nAChR subunit genes. Eur J Neurosci 31 978 PMID: 20377613
Do you know of a great paper that uses (-)-Cytisine from Tocris? Please let us know.
There are currently no reviews for this product. Be the first to review (-)-Cytisine and earn rewards!
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.