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Cat.No. 4762 - MIM1 | C17H21N3O3S
Description: Mcl-1 inhibitor; proapoptotic
Chemical Name: 4-(E)-[[(2Z)-2-cyclohexylimino)-4-methyl-1,3-thiazol-3(2H)-yl]imino]methyl]benzene-1,2,3-triol
Citations (1)
Literature (4)
Pathways (1)

Biological Activity

Inhibitor of Mcl-1. Inhibits Mcl-1 indirectly by induction of the proapoptotic Mcl-1 ligand NOXA via the unfolded protein response (UPR) pathway. Sensitizes leukemia cells to the Bcl-2 inhibitor venetoclax (ABT-199). Induces caspase-3/7 activation and cell death in Mcl-1-dependent leukemia cells. Also blocks Mcl-1-mediated suppression of tBID-induced Bax activation in vitro.

Technical Data

M. Wt 347.43
Formula C17H21N3O3S
Storage Store at +4°C
PubChem ID 135875424
Smiles CC2=CS/C(N2/N=C/C3=CC=C(O)C(O)=C3O)=N\C1CCCCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 34.74 100
ethanol 6.95 20

Preparing Stock Solutions

The following data is based on the product molecular weight 347.43. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.88 mL 14.39 mL 28.78 mL
5 mM 0.58 mL 2.88 mL 5.76 mL
10 mM 0.29 mL 1.44 mL 2.88 mL
50 mM 0.06 mL 0.29 mL 0.58 mL

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References are publications that support the biological activity of the product.

Cohen et al (2012) A competitive stapled peptide screen identifies a selective small molecule that overcomes MCL-1-dependent leukemia cell survival. Chem.Biol. 19 1175 PMID: 22999885

Mallick et al (2019) Confounding off-target effects of BH3 mimetics at commonly used concentrations: MIM1, UMI-77, and A-1210477. Cell Death Dis. 10 185 PMID: 30796196

If you know of a relevant reference for MIM1, please let us know.

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Keywords: MIM1, MIM1 supplier, Mcl-1, inhibitors, inhibits, proapoptotic, induces, apoptosis, caspases, activation, NOXA, Bcl-2, Family, 4762, Tocris Bioscience

1 Citation for MIM1

Citations are publications that use Tocris products. Selected citations for MIM1 include:

Li et al (2014) The androgen receptor mediates antiapoptotic function in myometrial cells. Autophagy 5 e1338 PMID: 25032861

Do you know of a great paper that uses MIM1 from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis

Neurodegeneration Product Guide

A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

  • Alzheimer's disease
  • Parkinson's disease
  • Huntington's disease

Parkinson's Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.

Programmed Cell Death

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Pathways for MIM1


Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.