Milnacipran hydrochloride

Discontinued Product

Milnacipran hydrochloride (Cat. No. 3286) has been withdrawn from sale for commercial reasons.
Description: 5-HT and NA reuptake inhibitor (SNRI)
Chemical Name: (1R*,2S*)-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide hydrochloride
Purity: ≥99% (HPLC)
Citations (1)
Literature (1)

Biological Activity for Milnacipran hydrochloride

Milnacipran hydrochloride is a orally active 5-HT and noradrenalin re-uptake inhibitor (SNRI) (IC50 values are 203 and 100 nM respectively) that displays no affinity at a range of other receptors. Causes adaptive changes to α1-adrenergic and 5-HT2A serotonergic systems when administered repeatedly. Exhibits antidepressive and antinociceptive activities in vivo.

Technical Data for Milnacipran hydrochloride

M. Wt 282.81
Formula C15H22N2O.HCl
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 101152-94-7
PubChem ID 73416954
Smiles NC[C@@H]1[C@@]([C@](N(CC)CC)=O)([C@]2=CC=CC=C2)C1.NC[C@H]3[C@]([C@](N(CC)CC)=O)([C@]4=CC=CC=C4)C3.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Milnacipran hydrochloride

References for Milnacipran hydrochloride

References are publications that support the biological activity of the product.

Moret et al (1985) Biochemical profile of midalcipran (F 2207), 1-phenyl-1-diethyl-aminocarbonyl-2-aminomethyl-cyclopropane (z) hydrochloride, a potential fourth generation antidepressant drug. Neuropharmacology 24 1211 PMID: 3005901

Maj et al (2000) Pharmacological effect of milnacipran, a new antidepressant, given repeatedly on the α1-adrenergic and serotonergic 5-HT2A systems. J.Neural.Transm. 107 1345 PMID: 11145008

Suzuki et al (2008) Antiallodynic and antihyperalgesic effect of milnac. in mice with spinal nerve ligation. Anesth.Analg. 106 1309 PMID: 18349211

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Keywords: Milnacipran hydrochloride, Milnacipran hydrochloride supplier, 5-HT, noradrenaline, reuptake, inhibitors, inhibits, SNRI, Transporters, NET, Adrenergic, Monoamine, Neurotransmitter, Serotonin, SERT, 5-Hydroxytryptamine, 3286, Tocris Bioscience

1 Citation for Milnacipran hydrochloride

Citations are publications that use Tocris products. Selected citations for Milnacipran hydrochloride include:

Burnham and Dickenson (2013) The antinociceptive effect of milnac. in the monosodium iodoacetate model of osteoarthritis pain and its relation to changes in descending inhibition. J Pharmacol Exp Ther 344 696 PMID: 23297162

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

5-HT Receptors Scientific Review

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.