Miconazole nitrate

Pricing Availability   Qty
Description: Azole antifungal agent
Chemical Name: 1-[2-(2,4-Dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-1H-imidazole nitrate
Purity: ≥99% (HPLC)
Literature (1)

Biological Activity for Miconazole nitrate

Miconazole nitrate is a antifungal agent. Inhibits lanosterol demethylase and induces formation of reactive oxygen species. Enhances the generation of mature oligodendrocytes from progenitor cells in vitro and promotes myelination in vivo. Attenuates disease severity in a mouse model of multiple sclerosis. Brain penetrant.

Compound Libraries for Miconazole nitrate

Miconazole nitrate is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Miconazole nitrate

M. Wt 479.14
Formula C18H14Cl4N2O.HNO3
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 22832-87-7
PubChem ID 68553
Smiles ClC1=CC(Cl)=CC=C1COC(CN3C=CN=C3)C2=CC=C(Cl)C=C2Cl.O[N+]([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Miconazole nitrate

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 47.91 100
ethanol 4.79 10

Preparing Stock Solutions for Miconazole nitrate

The following data is based on the product molecular weight 479.14. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.09 mL 10.44 mL 20.87 mL
5 mM 0.42 mL 2.09 mL 4.17 mL
10 mM 0.21 mL 1.04 mL 2.09 mL
50 mM 0.04 mL 0.21 mL 0.42 mL

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Product Datasheets for Miconazole nitrate

References for Miconazole nitrate

References are publications that support the biological activity of the product.

Chang et al (2005) Effect of miconazole on intracellular Ca2+ levels and proliferation in human osteosarcoma cells. Life Sci. 76 2091 PMID: 15826876

Najim et al (2015) Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo. Nature 522 216 PMID: 25896324

Hubler et al (2018) Accumulation of 8,9-unsaturated sterols drives oligodendrocyte formation and remyelination. Nature 560 372 PMID: 30046109

If you know of a relevant reference for Miconazole nitrate, please let us know.

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Citations for Miconazole nitrate

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