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Submit ReviewMiconazole nitrate
Description: Azole antifungal agent
Chemical Name: 1-[2-(2,4-Dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-1H-imidazole nitrate
Purity: ≥99% (HPLC)
Biological Activity for Miconazole nitrate
Miconazole nitrate is a antifungal agent. Inhibits lanosterol demethylase and induces formation of reactive oxygen species. Enhances the generation of mature oligodendrocytes from progenitor cells in vitro and promotes myelination in vivo. Attenuates disease severity in a mouse model of multiple sclerosis. Brain penetrant.
Compound Libraries for Miconazole nitrate
Miconazole nitrate is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.
Technical Data for Miconazole nitrate
| M. Wt | 479.14 |
| Formula | C18H14Cl4N2O.HNO3 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 22832-87-7 |
| PubChem ID | 68553 |
| InChI Key | MCCACAIVAXEFAL-UHFFFAOYSA-N |
| Smiles | ClC1=CC(Cl)=CC=C1COC(CN3C=CN=C3)C2=CC=C(Cl)C=C2Cl.O[N+]([O-])=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Miconazole nitrate
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 47.91 | 100 | |
| ethanol | 4.79 | 10 |
Preparing Stock Solutions for Miconazole nitrate
The following data is based on the product molecular weight 479.14. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.09 mL | 10.44 mL | 20.87 mL |
| 5 mM | 0.42 mL | 2.09 mL | 4.17 mL |
| 10 mM | 0.21 mL | 1.04 mL | 2.09 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.42 mL |
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Product Datasheets for Miconazole nitrate
References for Miconazole nitrate
References are publications that support the biological activity of the product.
Chang et al (2005) Effect of miconazole on intracellular Ca2+ levels and proliferation in human osteosarcoma cells. Life Sci. 76 2091 PMID: 15826876
Najim et al (2015) Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo. Nature 522 216 PMID: 25896324
Hubler et al (2018) Accumulation of 8,9-unsaturated sterols drives oligodendrocyte formation and remyelination. Nature 560 372 PMID: 30046109
If you know of a relevant reference for Miconazole nitrate, please let us know.
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Citations for Miconazole nitrate
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Immunology Product Listing
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