Mianserin hydrochloride

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Cat.No. 0997 - Mianserin hydrochloride | C18H20N2.HCl | CAS No. 21535-47-7
Description: 5-HT2 antagonist. Has moderate affinity for 5-HT6
Chemical Name: 1,2,3,4,10,14b-Hexahydro-2-methyldibenzo[c,f]pyrazino[1,2-a]azepine hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Non-selective 5-HT2 receptor antagonist (Ki values are 0.0080 and 0.0081 μM for human 5-HT2A and 5-HT2C receptors expressed in HEK293 cells respectively). Has moderate affinity for 5-HT6. Antidepressant.

Technical Data

M. Wt 300.83
Formula C18H20N2.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 21535-47-7
PubChem ID 68551
InChI Key YNPFMWCWRVTGKJ-UHFFFAOYSA-N
Smiles Cl.CN1CCN2C(C1)C1=CC=CC=C1CC1=C2C=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 3.01 10

Preparing Stock Solutions

The following data is based on the product molecular weight 300.83. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.32 mL 16.62 mL 33.24 mL
5 mM 0.66 mL 3.32 mL 6.65 mL
10 mM 0.33 mL 1.66 mL 3.32 mL
50 mM 0.07 mL 0.33 mL 0.66 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Hoyer et al (1994) VII. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol.Rev. 46 157 PMID: 7938165

Leonard (1982) On the mode of action of mianserin. Adv.Biochem.Psychopharmacol. 31 301 PMID: 6282060

Merck Index 12 6260 PMID:

Jensen et al (2013) Design, synthesis, and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-dazepin-3-ol analogues: novel 5-HT2A/5-HT2C receptor agonists with pro-cognitive J.Med.Chem. 56 1211 PMID: 23301527


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Keywords: Mianserin hydrochloride, supplier, 5-HT2, antagonists, moderate, affinity, 5-ht6, Non-Selective, Serotonin, Receptors, 5-Hydroxytryptamine, Non-selective, 5-HT2, 5-HT6, Receptors, Non-selective, 5-HT2, Tocris Bioscience

1 Citation for Mianserin hydrochloride

Citations are publications that use Tocris products. Selected citations for Mianserin hydrochloride include:

Wei et al (2010) JNK regulates serotonin-mediated proliferation and migration of pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 298 L863 PMID: 20228179


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5-HT Receptors

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.