Mianserin hydrochloride

Discontinued Product

Mianserin hydrochloride (Cat. No. 0997) has been withdrawn from sale for commercial reasons.
Description: 5-HT2 antagonist. Has moderate affinity for 5-HT6
Chemical Name: 1,2,3,4,10,14b-Hexahydro-2-methyldibenzo[c,f]pyrazino[1,2-a]azepine hydrochloride
Purity: ≥99% (HPLC)
Citations (2)
Literature (2)

Biological Activity for Mianserin hydrochloride

Mianserin hydrochloride is a non-selective 5-HT2 receptor antagonist (Ki values are 0.0080 and 0.0081 μM for human 5-HT2A and 5-HT2C receptors expressed in HEK293 cells respectively). Has moderate affinity for 5-HT6. Antidepressant.

Technical Data for Mianserin hydrochloride

M. Wt 300.83
Formula C18H20N2.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 21535-47-7
PubChem ID 68551
Smiles Cl.CN1CCN2C(C1)C1=CC=CC=C1CC1=C2C=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Mianserin hydrochloride

Certificate of Analysis / Product Datasheet
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References for Mianserin hydrochloride

References are publications that support the biological activity of the product.

Hoyer et al (1994) VII. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol.Rev. 46 157 PMID: 7938165

Leonard (1982) On the mode of action of mianserin. Adv.Biochem.Psychopharmacol. 31 301 PMID: 6282060

Merck Index 12 6260

Jensen et al (2013) Design, synthesis, and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-dazepin-3-ol analogues: novel 5-HT2A/5-HT2C receptor agonists with pro-cognitive J.Med.Chem. 56 1211 PMID: 23301527

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Keywords: Mianserin hydrochloride, Mianserin hydrochloride supplier, 5-HT2, antagonists, moderate, affinity, 5-ht6, Non-Selective, Serotonin, Receptors, 5-Hydroxytryptamine, Non-selective, 5-HT6, 0997, Tocris Bioscience

2 Citations for Mianserin hydrochloride

Citations are publications that use Tocris products. Selected citations for Mianserin hydrochloride include:

Wei et al (2010) JNK regulates serotonin-mediated proliferation and migration of pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 298 L863 PMID: 20228179

Mbaki (2008) Investigation of the role of 5-HT2 receptor subtypes in the control of the bladder and the urethra in the anaesthetized female rat. Br J Pharmacol 155 343 PMID: 18604238

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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5-HT Receptors Scientific Review

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