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Non-selective 5-HT2 receptor antagonist (Ki values are 0.0080 and 0.0081 μM for human 5-HT2A and 5-HT2C receptors expressed in HEK293 cells respectively). Has moderate affinity for 5-HT6. Antidepressant.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 300.83. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||33.24 mL||166.21 mL||332.41 mL|
|0.5 mM||6.65 mL||33.24 mL||66.48 mL|
|1 mM||3.32 mL||16.62 mL||33.24 mL|
|5 mM||0.66 mL||3.32 mL||6.65 mL|
References are publications that support the biological activity of the product.
Hoyer et al (1994) VII. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol.Rev. 46 157 PMID: 7938165
Leonard (1982) On the mode of action of mianserin. Adv.Biochem.Psychopharmacol. 31 301 PMID: 6282060
Merck Index 12 6260
Jensen et al (2013) Design, synthesis, and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-dazepin-3-ol analogues: novel 5-HT2A/5-HT2C receptor agonists with pro-cognitive J.Med.Chem. 56 1211 PMID: 23301527
If you know of a relevant reference for Mianserin hydrochloride, please let us know.
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Keywords: Mianserin hydrochloride, Mianserin hydrochloride supplier, 5-HT2, antagonists, moderate, affinity, 5-ht6, Non-Selective, Serotonin, Receptors, 5-Hydroxytryptamine, Non-selective, 5-HT6, 0997, Tocris Bioscience
2 Citations for Mianserin hydrochloride
Citations are publications that use Tocris products. Selected citations for Mianserin hydrochloride include:
Wei et al (2010) JNK regulates serotonin-mediated proliferation and migration of pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 298 L863 PMID: 20228179
Mbaki (2008) Investigation of the role of 5-HT2 receptor subtypes in the control of the bladder and the urethra in the anaesthetized female rat. Br J Pharmacol 155 343 PMID: 18604238
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.