You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
MI 2 (MALT1 inhibitor)
MALT1 inhibitor (IC50 = 5.84 μM). Binds directly to MALT1 and irreversibly suppresses protease function. Decreases NF-κB activity induced by MALT1. Inhibits cell proliferation and MALT1-mediated cleavage activity. Suppresses human TMD8 and HBL-1 activated B cell-like diffuse large B cell lymphoma (ABC-DLBCL) tumor xenografts in mice and primary human ABC-DLBCLs ex vivo.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 455.72. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.19 mL||10.97 mL||21.94 mL|
|5 mM||0.44 mL||2.19 mL||4.39 mL|
|10 mM||0.22 mL||1.1 mL||2.19 mL|
|50 mM||0.04 mL||0.22 mL||0.44 mL|
References are publications that support the biological activity of the product.
Fontan et al (2012) MALT1 small molecule inhibitors specifically suppress ABC-DLBCL in vitro and in vivo. Cancer Cell 22 812 PMID: 23238016
If you know of a relevant reference for MI 2 (MALT1 inhibitor), please let us know.
View Related Products by Product Action
Keywords: MI 2 (MALT1 inhibitor), MI 2 (MALT1 inhibitor) supplier, MI2, MALT, 1, inhibitors, inhibits, NF-KB, NFKB, NF, Kappa, B, NFκB, lymphoma, ABC-DLBCL, Other, Proteases, 4848, Tocris Bioscience
Citations for MI 2 (MALT1 inhibitor)
Citations are publications that use Tocris products.
Currently there are no citations for MI 2 (MALT1 inhibitor). Do you know of a great paper that uses MI 2 (MALT1 inhibitor) from Tocris? Please let us know.
Reviews for MI 2 (MALT1 inhibitor)
Average Rating: 5 (Based on 1 Review.)
Have you used MI 2 (MALT1 inhibitor)?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
MALT1 protease inhibitor MI-2 suppress RelB cleavage in a dose-dependent manner in U2OS osteosarcoma cells. Cells were pretreated with increasing concentration of MI2 inhibitor (0.25, 0.5, 1, or 2 µM) for 1 h prior to stimulation with 2 U/mL thrombin for an additional 3 h. MDA-MB-231 cells stimulated with thrombin also show evidence of RelB cleavage that is suppressed by MI-2 (2 μM).
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
New Product Guide [Spring/Summer 2019]New
Our new product guide highlights over 215 new products added to the Tocris Bioscience range during the first half of 2019.
- 7-TM Receptors
- Enzyme-Linked Receptors
- Ion Channels
- Nuclear Receptors
- Fluorescent Imaging
- Signal Transduction
- Stem Cells