MI 2 (MALT1 inhibitor)

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Cat.No. 4848 - MI 2 (MALT1 inhibitor) | C19H17Cl3N4O3 | CAS No. 1047953-91-2
Description: MALT1 inhibitor
Chemical Name: 2-Chloro-N-[4-[5-(3,4-dichlorophenyl)-3-(2-methoxyethoxy)-1H-1,2,4-triazol-1-yl]phenylacetamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

MALT1 inhibitor (IC50 = 5.84 μM). Binds directly to MALT1 and irreversibly suppresses protease function. Decreases NF-κB activity induced by MALT1. Inhibits cell proliferation and MALT1-mediated cleavage activity. Suppresses human TMD8 and HBL-1 activated B cell-like diffuse large B cell lymphoma (ABC-DLBCL) tumor xenografts in mice and primary human ABC-DLBCLs ex vivo.

Technical Data

M. Wt 455.72
Formula C19H17Cl3N4O3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1047953-91-2
PubChem ID 45942672
InChI Key TWJGQZBSEMDPQP-UHFFFAOYSA-N
Smiles O=C(CCl)NC(C=C3)=CC=C3N1C(C2=CC(Cl)=C(Cl)C=C2)=NC(OCCOC)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 45.57 100
ethanol 9.11 20

Preparing Stock Solutions

The following data is based on the product molecular weight 455.72. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.19 mL 10.97 mL 21.94 mL
5 mM 0.44 mL 2.19 mL 4.39 mL
10 mM 0.22 mL 1.1 mL 2.19 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Fontan et al (2012) MALT1 small molecule inhibitors specifically suppress ABC-DLBCL in vitro and in vivo. Cancer Cell 22 812 PMID: 23238016


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Keywords: MI 2 (MALT1 inhibitor), supplier, MI2, MALT, 1, inhibitors, inhibits, NF-KB, NFKB, NF, Kappa, B, NFκB, lymphoma, ABC-DLBCL, Other, Proteases, Other, Proteases, Tocris Bioscience

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New Product Guide

New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Apoptosis
  • Cell Metabolism
  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells

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