MI 14

Pricing Availability   Qty
Cat.No. 5604 - MI 14 | C19H23ClN6O3S | CAS No. 1715934-43-2
Description: Potent and selective PI 4-kinase IIIβ inhibitor
Chemical Name: N-[2-[[6-Chloro-3-[3-[(dimethylamino)sulfonyl]phenyl]-2-methylimidazo[1,2-b]pyridazin-8-yl]amino]ethyl]acetamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent and selective PI 4-K IIIβ inhibitor (IC50 = 54 nM). Exhibits >1,800-fold selectivity for PI 4-K IIIβ over PI 4-K IIIα and PI 4-K IIα, respectively. Exhibits antiviral activity against single-stranded positive sense RNA viruses in HeLa cell-based assays.

Compound Libraries

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Technical Data

M. Wt 450.94
Formula C19H23ClN6O3S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1715934-43-2
PubChem ID 91758319
InChI Key PSTAJIONBVMKLA-UHFFFAOYSA-N
Smiles CC2=C(C3=CC=CC(S(N(C)C)(=O)=O)=C3)N1N=C(Cl)C=C(NCCNC(C)=O)C1=N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 9.02 20

Preparing Stock Solutions

The following data is based on the product molecular weight 450.94. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 11.09 mL 55.44 mL 110.88 mL
1 mM 2.22 mL 11.09 mL 22.18 mL
2 mM 1.11 mL 5.54 mL 11.09 mL
10 mM 0.22 mL 1.11 mL 2.22 mL

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References

References are publications that support the biological activity of the product.

Mejdrová et al (2015) Highly selective phosphatidylinositol 4-kinase IIIβ inhibitors and structural insight into their mode of action. J.Med.Chem. 58 3767 PMID: 25897704


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Keywords: MI 14, MI 14 supplier, MI14, antivirals, phostphatidylinositol, 4, kinases, inhibitors, inhibits, IIIbeta, PI4-Kinase, RNA, viruses, potent, selective, Other, Kinases, Antivirals, 5604, Tocris Bioscience

Citations for MI 14

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