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Potent and selective PI 4-K IIIβ inhibitor (IC50 = 54 nM). Exhibits >1,800-fold selectivity for PI 4-K IIIβ over PI 4-K IIIα and PI 4-K IIα, respectively. Exhibits antiviral activity against single-stranded positive sense RNA viruses in HeLa cell-based assays.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 450.94. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||11.09 mL||55.44 mL||110.88 mL|
|1 mM||2.22 mL||11.09 mL||22.18 mL|
|2 mM||1.11 mL||5.54 mL||11.09 mL|
|10 mM||0.22 mL||1.11 mL||2.22 mL|
References are publications that support the biological activity of the product.
Mejdrová et al (2015) Highly selective phosphatidylinositol 4-kinase IIIβ inhibitors and structural insight into their mode of action. J.Med.Chem. 58 3767 PMID: 25897704
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Keywords: MI 14, MI 14 supplier, MI14, antivirals, phostphatidylinositol, 4, kinases, inhibitors, inhibits, IIIbeta, PI4-Kinase, RNA, viruses, potent, selective, Other, Kinases, Antivirals, 5604, Tocris Bioscience
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