Potent and selective PI 4-K IIIβ inhibitor (IC50 = 54 nM). Exhibits >1,800-fold selectivity for PI 4-K IIIβ over PI 4-K IIIα and PI 4-K IIα, respectively. Exhibits antiviral activity against single-stranded positive sense RNA viruses in HeLa cell-based assays.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 450.94. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.22 mL||11.09 mL||22.18 mL|
|5 mM||0.44 mL||2.22 mL||4.44 mL|
|10 mM||0.22 mL||1.11 mL||2.22 mL|
|50 mM||0.04 mL||0.22 mL||0.44 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Mejdrová et al (2015) Highly selective phosphatidylinositol 4-kinase IIIβ inhibitors and structural insight into their mode of action. J.Med.Chem. 58 3767 PMID: 25897704
If you know of a relevant reference for MI 14, please let us know.
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Keywords: MI 14, supplier, MI14, antivirals, phostphatidylinositol, 4, kinases, inhibitors, inhibits, IIIbeta, PI4-Kinase, RNA, viruses, potent, selective, Other, Kinases, Tocris Bioscience
Citations for MI 14
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