MI 14

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Description: Potent and selective PI 4-kinase IIIβ inhibitor
Chemical Name: N-[2-[[6-Chloro-3-[3-[(dimethylamino)sulfonyl]phenyl]-2-methylimidazo[1,2-b]pyridazin-8-yl]amino]ethyl]acetamide
Purity: ≥98% (HPLC)
Citations (1)

Biological Activity for MI 14

MI 14 is a potent and selective PI 4-K IIIβ inhibitor (IC50 = 54 nM). Exhibits >1,800-fold selectivity for PI 4-K IIIβ over PI 4-K IIIα and PI 4-K IIα, respectively. Exhibits antiviral activity against single-stranded positive sense RNA viruses in HeLa cell-based assays.

Compound Libraries for MI 14

MI 14 is also offered as part of the Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for MI 14

M. Wt 450.94
Formula C19H23ClN6O3S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1715934-43-2
PubChem ID 91758319
Smiles CC2=C(C3=CC=CC(S(N(C)C)(=O)=O)=C3)N1N=C(Cl)C=C(NCCNC(C)=O)C1=N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for MI 14

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 9.02 20

Preparing Stock Solutions for MI 14

The following data is based on the product molecular weight 450.94. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 11.09 mL 55.44 mL 110.88 mL
1 mM 2.22 mL 11.09 mL 22.18 mL
2 mM 1.11 mL 5.54 mL 11.09 mL
10 mM 0.22 mL 1.11 mL 2.22 mL

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References for MI 14

References are publications that support the biological activity of the product.

Mejdrová et al (2015) Highly selective phosphatidylinositol 4-kinase IIIβ inhibitors and structural insight into their mode of action. J.Med.Chem. 58 3767 PMID: 25897704

If you know of a relevant reference for MI 14, please let us know.

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1 Citation for MI 14

Citations are publications that use Tocris products. Selected citations for MI 14 include:

Wooree et al (2021) Conformational specificity of opioid receptors is determined by subcellular location irrespective of agonist. Elife 10 PMID: 34013886

Do you know of a great paper that uses MI 14 from Tocris? Please let us know.

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