MG 101

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Cat.No. 3358 - MG 101 | C20H37N3O4 | CAS No. 110044-82-1
Description: Calpain inhibitor; activates p53-dependent apoptosis
Alternative Names: Calpain inhibitor-1
Chemical Name: N-Acetyl-L-leucine-L-leucine-L-norleucinal
Datasheet
Citations (1)
Pathways

Biological Activity

Calpain inhibitor (IC50 = 0.09 μM) that activates p53-dependent apoptosis in tumor cell lines. Increases activated p53, p21 and caspase levels and promotes cell cycle arrest through inhibition of cyclin D degradation in vitro. Also attenuates ischemia/reperfusion injury in cardiomyocytes, hepatocytes and renal tubular cells through downregulation of iNOS and COX-2 expression.

Technical Data

M. Wt 383.53
Formula C20H37N3O4
Storage Store at -20°C
CAS Number 110044-82-1
PubChem ID 443118
InChI Key FMYKJLXRRQTBOR-BZSNNMDCSA-N
Smiles CCCC[C@H](NC([C@@H](N[C@@]([C@H](CC(C)C)NC(C)=O)=O)CC(C)C)=O)C=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 19.18 50
ethanol 9.59 25

Preparing Stock Solutions

The following data is based on the product molecular weight 383.53. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.61 mL 13.04 mL 26.07 mL
5 mM 0.52 mL 2.61 mL 5.21 mL
10 mM 0.26 mL 1.3 mL 2.61 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Atencio et al (2000) Calpain inhibitor 1 activates p53-dependent apoptosis in tumor cell lines. Cell Growth Differ. 11 247 PMID: 10845425

Chatterjee et al (2001) Calpain inhibitor-1 reduces renal ischemia/reperfusion injury in the rat. Kidney Int. 59 2073 PMID: 11380809

Sherwood et al (1993) In vivo inhibition of cyclin B degradation and induction of cell-cycle arrest in mammalian cells by the neutral cysteine protease inhibitor N-acetylleucylleucylnorleucinal. Proc.Natl.Acad.Sci.USA 90 3353 PMID:

Perrin et al (2002) In vitro antioxidant properties of calpain inhibitors: leupeptin and calpain inhibitor-1. Cell Mol.Biol. 48 OL267 PMID:


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Keywords: Calpain inhibitors inhibits Proteinases Proteases MG101 Calpain inhibitor-1 Calpains

1 Citation for MG 101

Citations are publications that use Tocris products. Selected citations for MG 101 include:

Ishizuka et al (2016) PAFR activation of NF-& #954;B p65 or p105 precursor dictates pro-and anti-inflammatory responses during TLR activation in murine macrophages Scientific Reports 6 32092 PMID: 27554194


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Reviews

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Literature in this Area

Pathways for MG 101

Apoptosis

Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.

Protocols

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