MG 101

Discontinued Product

MG 101 (Cat. No. 3358) has been withdrawn from sale for commercial reasons.
Description: Calpain inhibitor; activates p53-dependent apoptosis
Alternative Names: Calpain inhibitor-1
Chemical Name: N-Acetyl-L-leucine-L-leucine-L-norleucinal
Citations (1)
Literature (1)
Pathways (1)

Biological Activity for MG 101

Calpain inhibitor (IC50 = 0.09 μM) that activates p53-dependent apoptosis in tumor cell lines. Increases activated p53, p21 and caspase levels and promotes cell cycle arrest through inhibition of cyclin D degradation in vitro. Also attenuates ischemia/reperfusion injury in cardiomyocytes, hepatocytes and renal tubular cells through downregulation of iNOS and COX-2 expression.

Technical Data for MG 101

M. Wt 383.53
Formula C20H37N3O4
Storage Store at -20°C
CAS Number 110044-82-1
PubChem ID 443118
Smiles CCCC[C@H](NC([C@@H](N[C@@]([C@H](CC(C)C)NC(C)=O)=O)CC(C)C)=O)C=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for MG 101

Certificate of Analysis / Product Datasheet
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References for MG 101

References are publications that support the biological activity of the product.

Atencio et al (2000) Calpain inhibitor 1 activates p53-dependent apoptosis in tumor cell lines. Cell Growth Differ. 11 247 PMID: 10845425

Chatterjee et al (2001) Calpain inhibitor-1 reduces renal ischemia/reperfusion injury in the rat. Kidney Int. 59 2073 PMID: 11380809

Sherwood et al (1993) In vivo inhibition of cyclin B degradation and induction of cell-cycle arrest in mammalian cells by the neutral cysteine protease inhibitor N-acetylleucylleucylnorleucinal. Proc.Natl.Acad.Sci.USA 90 3353

Perrin et al (2002) In vitro antioxidant properties of calpain inhibitors: leupeptin and calpain inhibitor-1. Cell Mol.Biol. 48 OL267

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Keywords: MG 101, MG 101 supplier, Calpain, inhibitors, inhibits, Proteinases, Proteases, MG101, inhibitor-1, Calpains, Calcium-Sensitive, 3358, Tocris Bioscience

1 Citation for MG 101

Citations are publications that use Tocris products. Selected citations for MG 101 include:

Ishizuka et al (2016) PAFR activation of NF-& #954;B p65 or p105 precursor dictates pro-and anti-inflammatory responses during TLR activation in murine macrophages Scientific Reports 6 32092 PMID: 27554194

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cell Cycle and DNA Damage Research Product Guide

Cell Cycle and DNA Damage Research Product Guide

This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:

  • Cell Cycle and Mitosis
  • DNA Damage Repair
  • Targeted Protein Degradation
  • Ubiquitin Proteasome Pathway
  • Chemotherapy Targets

Pathways for MG 101

Apoptosis Signaling Pathway

Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.