MFZ 10-7

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Cat.No. 4438 - MFZ 10-7 | C15H9FN2.HCl | CAS No. 1224431-15-5
Description: Negative allosteric modulator at mGlu5
Chemical Name: 3-Fluoro-5-[2-(6-methyl-2-pyridinyl)ethynyl]benzonitrile hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

High affinity negative allosteric modulator at the mGlu5 receptor (Ki = 0.67 nM). Potently inhibits mGlu5 glutamate-mediated calcium mobilization (IC50 = 1.22 nM). Inhibits cocaine-taking and cocaine-seeking behavior in rats.

Technical Data

M. Wt 272.7
Formula C15H9FN2.HCl
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 1224431-15-5
PubChem ID 90488944
InChI Key WRHOKQFFLQKKNL-UHFFFAOYSA-N
Smiles CC1=NC(C#CC2=CC(C#N)=CC(F)=C2)=CC=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 27.27 100
ethanol 27.27 100

Preparing Stock Solutions

The following data is based on the product molecular weight 272.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.67 mL 18.34 mL 36.67 mL
5 mM 0.73 mL 3.67 mL 7.33 mL
10 mM 0.37 mL 1.83 mL 3.67 mL
50 mM 0.07 mL 0.37 mL 0.73 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Alagille et al (2011) Potent mGluR5 antagonists: pyridyl and thiazolyl-ethynyl-3,5-disubstituted-phenyl series. Bioorg.Med.Chem.Lett. 21 3243 PMID: 21546249

Keck et al (2012) Metabotropic glutamate receptor 5 negative allosteric modulators as novel tools for in vivo investigation. ACS Med.Chem.Lett. 3 544 PMID: 22924094

Keck et al (2014) A novel mGluR5 antagonist, MFZ 10-7, inhibits cocaine-taking and cocaine-seeking behavior in rats. Addict.Biol. 19 195 PMID: 24001208


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Citations for MFZ 10-7

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