Pricing Availability   Qty
Description: Inhibitor of pro-inflammatory mediator release from mast cells
Chemical Name: 2-(3,4-Dimethoxyphenyl)-5,7-dimethoxy-4H-1-benzopyran-4-one
Purity: ≥98% (HPLC)
Literature (4)

Biological Activity for Methoxyluteolin

Methoxyluteolin inhibits release of pro-inflammatory mediators from mast cells and decreases gene expression and release of TNF, VEGF and IL-8/CXCL8. The product also significantly inhibits IL-33 stimulated expression and release of CCL5 and CCL2. Methoxyluteolin pretreatment of LAD2 mast cells decreases gene expression of TNF, CXCL8 and VEGF in response to neurotensin or substance P via mTOR activation.

Technical Data for Methoxyluteolin

M. Wt 342.35
Formula C19H18O6
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 855-97-0
PubChem ID 631170
Smiles O=C1C=C(OC2=CC(OC)=CC(OC)=C12)C=3C=CC(OC)=C(OC)C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Methoxyluteolin

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 6.85 20

Preparing Stock Solutions for Methoxyluteolin

The following data is based on the product molecular weight 342.35. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 14.6 mL 73.02 mL 146.05 mL
1 mM 2.92 mL 14.6 mL 29.21 mL
2 mM 1.46 mL 7.3 mL 14.6 mL
10 mM 0.29 mL 1.46 mL 2.92 mL

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Product Datasheets for Methoxyluteolin

References for Methoxyluteolin

References are publications that support the biological activity of the product.

Abubakr Bawazeer and Theoharides (2019) IL-33 stimulates human mast cell release of CCL5 and CCL2 via MAPK and NF-κB, inhibited by methoxyluteolin. Eur.J.Pharmacol. 865 PMID: 31669588

Weng et al (2015) The novel flavone tetramethoxyluteolin is a potent inhibitor of human mast cells. J.Allergy Clin.Immunol. 135 1044 PMID: 25498791

Patel and Theoharides (2017) Methoxyluteolin inhibits neuropeptide-stimulated proinflammatory mediator release via mTOR activation from human mast cells. J.Pharmacol.Exp.Ther. 361 462 PMID: 28404689

Taracanova et al (2018) Substance P and IL-33 administered together stimulate a marked secretion of IL-1β from human mast cells, inhibited by methoxyluteolin. Proc.Nat.Acad.Sci. USA 115 9381 PMID: 30232261

If you know of a relevant reference for Methoxyluteolin, please let us know.

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Keywords: Methoxyluteolin, Methoxyluteolin supplier, methoxyluteolin, mast, cells, inhibitors, inhibits, cytokines, Cytokines, 7320, Tocris Bioscience

Citations for Methoxyluteolin

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