Mephedrone hydrochloride

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Cat.No. 4443 - Mephedrone hydrochloride | C11H15NO.HCl | CAS No. 1189726-22-4
Description: Inhibits synaptosomal dopamine and 5-HT uptake
Chemical Name: (±)-2-Methylamino-1-(4-methylphenyl)propan-1-one hydrochloride
Purity: ≥99% (HPLC)

Biological Activity

Inhibits striatal dopamine uptake and hippocampal 5-HT uptake in synaptosomes (IC50 values are 467 and 558 nM respectively). Administration causes a decrease in dopamine and 5-HT transporter function. Synthetic CNS stimulant; brain penetrant.

Technical Data

M. Wt 213.7
Formula C11H15NO.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 1189726-22-4
PubChem ID 46782120
Smiles CC1=CC=C(C(C(C)NC)=O)C=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 21.37 100
water 21.37 100

Preparing Stock Solutions

The following data is based on the product molecular weight 213.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.68 mL 23.4 mL 46.79 mL
5 mM 0.94 mL 4.68 mL 9.36 mL
10 mM 0.47 mL 2.34 mL 4.68 mL
50 mM 0.09 mL 0.47 mL 0.94 mL

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Product Datasheets

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References are publications that support the biological activity of the product.

Hadlock et al (2011) 4-methylmethcathinone (mephedrone): neuropharmacological effects of a designer stimulant of abuse. J.Pharmacol.Exp.Ther. 339 530 PMID: 21810934

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