Mephedrone hydrochloride

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Cat.No. 4443 - Mephedrone hydrochloride | C11H15NO.HCl | CAS No. 1189726-22-4
Description: Inhibits synaptosomal dopamine and 5-HT uptake
Chemical Name: (±)-2-Methylamino-1-(4-methylphenyl)propan-1-one hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Inhibits striatal dopamine uptake and hippocampal 5-HT uptake in synaptosomes (IC50 values are 467 and 558 nM respectively). Administration causes a decrease in dopamine and 5-HT transporter function. Synthetic CNS stimulant; brain penetrant.

Technical Data

M. Wt 213.7
Formula C11H15NO.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 1189726-22-4
PubChem ID 46782120
InChI Key DLQZFTUKJGRPLZ-UHFFFAOYSA-N
Smiles CC1=CC=C(C(C(C)NC)=O)C=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 21.37 100
ethanol 10.69 50
water 21.37 100

Preparing Stock Solutions

The following data is based on the product molecular weight 213.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.68 mL 23.4 mL 46.79 mL
5 mM 0.94 mL 4.68 mL 9.36 mL
10 mM 0.47 mL 2.34 mL 4.68 mL
50 mM 0.09 mL 0.47 mL 0.94 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Hadlock et al (2011) 4-methylmethcathinone (mephedrone): neuropharmacological effects of a designer stimulant of abuse. J.Pharmacol.Exp.Ther. 339 530 PMID: 21810934


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Citations for Mephedrone hydrochloride

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Literature in this Area

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Pathways for Mephedrone hydrochloride

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