MDNI-caged-L-glutamate

Description: Stable photoreleaser of L-glutamate
Alternative Names: caged MDNI glutamate, DNI glutamate, DNI-GLU
Chemical Name: (S)-α-Amino-2,3-dihydro-4-methoxy-5,7-dinitro-δ-oxo-1H-indole-1-pentanoic acid
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (5)

Biological Activity

Rapidly and efficiently releases glutamate (Cat. No. 0218) when photolysed (350 - 365 nm excitation). Water soluble and stable at neutral pH, and pharmacologically inactive at neuronal glutamate receptors (up to 200 μM). 5.5 times more photosensitive than MNI-caged L-glutamate (Cat. No. 1490). Laser activation of MDNI-glu evokes a rapid increase in intracellular Ca2+ concentration in astrocytes.

Important information

As a result of the manufacturing process, this product contains some residual TFA. The amount of TFA is batch dependant and will appear in the batch molecular formula.

Technical Data

M. Wt 368.3
Formula C14H16N4O8
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 864085-92-7
PubChem ID 124221751
InChI Key SYNWQVVPBORTQE-QMMMGPOBSA-N
Smiles O=C(CC[C@H](N)C(O)=O)N1C2=C([N+]([O-])=O)C=C([N+]([O-])=O)C(OC)=C2CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Fedoryak et al (2005) Synthesis of a caged glutamate for efficient one- and two-photon photorelease on living cells. Chem. Commun. (Camb.) 7 3664 PMID: 16027904

Papageorgiou et al (2005) Synthetic and photochemical studies of substituted 1-acyl-7-nitroindolines. Photochem.Photobiol.Sci. 4 887 PMID: 16252044

Popovic et al (2015) Electrical behaviour of dendritic spines as revealed by voltage imaging. Nat.Commun. 6 8436 PMID: 26436431

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Citations for MDNI-caged-L-glutamate

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

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