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Biological Activity for MDNI-caged-L-glutamate
Rapidly and efficiently releases glutamate (Cat. No. 0218) when photolysed (350 - 365 nm excitation). Water soluble and stable at neutral pH, and pharmacologically inactive at neuronal glutamate receptors (up to 200 μM). 5.5 times more photosensitive than MNI-caged L-glutamate (Cat. No. 1490). Laser activation of MDNI-glu evokes a rapid increase in intracellular Ca2+ concentration in astrocytes.
Important information for MDNI-caged-L-glutamate
As a result of the manufacturing process, this product contains some residual TFA. The amount of TFA is batch dependant and will appear in the batch molecular formula.
Technical Data for MDNI-caged-L-glutamate
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for MDNI-caged-L-glutamate
References for MDNI-caged-L-glutamate
References are publications that support the biological activity of the product.
Fedoryak et al (2005) Synthesis of a caged glutamate for efficient one- and two-photon photorelease on living cells. Chem. Commun. (Camb.) 7 3664 PMID: 16027904
Papageorgiou et al (2005) Synthetic and photochemical studies of substituted 1-acyl-7-nitroindolines. Photochem.Photobiol.Sci. 4 887 PMID: 16252044
Popovic et al (2015) Electrical behaviour of dendritic spines as revealed by voltage imaging. Nat.Commun. 6 8436 PMID: 26436431
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Citations for MDNI-caged-L-glutamate
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Currently there are no citations for MDNI-caged-L-glutamate.
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Literature in this Area
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