L-Glutamic acid

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Cat.No. 0218 - L-Glutamic acid | C5H9NO4 | CAS No. 56-86-0
Description: Endogenous, non-selective glutamate receptor agonist
Chemical Name: (S)-1-Aminopropane-1,3-dicarboxylic acid
Datasheet
Citations (8)
Reviews (2)
Literature (6)

Biological Activity

The predominant excitatory transmitter in the mammalian central nervous system. Acts at ionotropic and metabotropic glutamate receptors.

MNI-caged-L-glutamate and D-isomer also available.

Technical Data

M. Wt 147.13
Formula C5H9NO4
Storage Store at RT
CAS Number 56-86-0
PubChem ID 33032
InChI Key WHUUTDBJXJRKMK-VKHMYHEASA-N
Smiles [H][C@@](CCC(O)=O)(N)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. NaOH 100

Preparing Stock Solutions

The following data is based on the product molecular weight 147.13. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 6.8 mL 33.98 mL 67.97 mL
5 mM 1.36 mL 6.8 mL 13.59 mL
10 mM 0.68 mL 3.4 mL 6.8 mL
50 mM 0.14 mL 0.68 mL 1.36 mL

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References

References are publications that support the biological activity of the product.

Monaghan et al (1989) The excitatory amino acid receptors: their classes, pharmacology and distinct properties in the function of the central nervous system. Annu.Rev.Pharmacol.Toxicol. 29 365 PMID: 2543272

Watkins and Evans (1981) Excitatory amino acid transmitters. Annu.Rev.Pharmacol.Toxicol. 21 165 PMID: 6112965

Yang and Stockwell et al (2016) Ferroptosis: Death by lipid peroxidation. Trends Cell Biol. 26 165 PMID: 26653790


If you know of a relevant reference for L-Glutamic acid, please let us know.

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Keywords: L-Glutamic acid, L-Glutamic acid supplier, Endogenous, non-selective, agonists, Glutamate, Ionotropic, Non-Selective, iGluR, Receptors, mGlur, Metabotropic, Non-selective, mGlu, Ferroptosis, Amino, Acids, 0218, Tocris Bioscience

8 Citations for L-Glutamic acid

Citations are publications that use Tocris products. Selected citations for L-Glutamic acid include:

Owaisat et al (2012) In vivo comparison of harmine efficacy against psychostimulants: preferential inhibition of the cocaine response through a glutamatergic mechanism. Neurosci Lett 525 12 PMID: 22877698

Tallarida et al (2012) Glutamate carboxypeptidase II (GCPII) inhibitor displays anti-glutamate and anti-cocaine effects in an invertebrate assay. Amino Acids 42 2521 PMID: 21850438

Moreno et al (2012) Identification of three residues essential for 5-hydroxytryptamine 2A-metabotropic glutamate 2 (5-HT2A·mGlu2) receptor heteromerization and its psychoactive behavioral function. J Biol Chem 287 44301 PMID: 23129762

Moreno et al (2011) Maternal influenza viral infection causes schizophrenia-like alterations of 5-HT2A and mGlu2 receptors in the adult offspring. J Neurosci 31 1863 PMID: 21289196


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Reviews for L-Glutamic acid

Average Rating: 4.5 (Based on 2 Reviews.)

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Neuron glia culture.
By Anonymous on 07/12/2020
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: Mixed neuron-glia

L-glutamate (10 or 100μM)

Incubate for 24h

PMID: 31257852
review image

works good.
By Anonymous on 04/04/2020
Assay Type: In Vitro
Species: Rat
Cell Line/Tissue: Sprague-Dawley rats primary neuronal

10 μM L-Glutamic acid for 2 hours

PMID: 31291571 Reference
review image

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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