Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewL-Glutamic acid
Description: Endogenous, non-selective glutamate receptor agonist
Chemical Name: (S)-1-Aminopropane-1,3-dicarboxylic acid
Biological Activity for L-Glutamic acid
L-Glutamic acid is a the predominant excitatory transmitter in the mammalian central nervous system. L-Glutamic acid acts at ionotropic and metabotropic glutamate receptors.
MNI-caged-L-glutamate (Cat. No. 1490) also available.
Technical Data for L-Glutamic acid
| M. Wt | 147.13 |
| Formula | C5H9NO4 |
| Storage | Store at RT |
| CAS Number | 56-86-0 |
| PubChem ID | 33032 |
| InChI Key | WHUUTDBJXJRKMK-VKHMYHEASA-N |
| Smiles | [H][C@@](CCC(O)=O)(N)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for L-Glutamic acid
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1eq. NaOH | 100 |
Preparing Stock Solutions for L-Glutamic acid
The following data is based on the product molecular weight 147.13. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 6.8 mL | 33.98 mL | 67.97 mL |
| 5 mM | 1.36 mL | 6.8 mL | 13.59 mL |
| 10 mM | 0.68 mL | 3.4 mL | 6.8 mL |
| 50 mM | 0.14 mL | 0.68 mL | 1.36 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets for L-Glutamic acid
References for L-Glutamic acid
References are publications that support the biological activity of the product.
Monaghan et al (1989) The excitatory amino acid receptors: their classes, pharmacology and distinct properties in the function of the central nervous system. Annu.Rev.Pharmacol.Toxicol. 29 365 PMID: 2543272
Watkins and Evans (1981) Excitatory amino acid transmitters. Annu.Rev.Pharmacol.Toxicol. 21 165 PMID: 6112965
Yang and Stockwell et al (2016) Ferroptosis: Death by lipid peroxidation. Trends Cell Biol. 26 165 PMID: 26653790
If you know of a relevant reference for L-Glutamic acid, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: L-Glutamic acid, L-Glutamic acid supplier, Endogenous, non-selective, agonists, Glutamate, Ionotropic, Non-Selective, iGluR, Receptors, mGlur, Metabotropic, Non-selective, mGlu, Ferroptosis, Amino, Acids, 0218, Tocris Bioscience
8 Citations for L-Glutamic acid
Citations are publications that use Tocris products. Selected citations for L-Glutamic acid include:
Galici et al (2006) Biphenyl-indanone A, a positive allosteric modulator of the metabotropic glutamate receptor subtype 2, has antipsychotic- and anxiolytic-like effects in mice. J Pharmacol Exp Ther 318 173 PMID: 16608916
Falcucci et al (2019) Novel positive allosteric modulators of glutamate transport have neuroprotective properties in an in vitro excitotoxic model. ACS Chem Neurosci 10 3437 PMID: 31257852
Schitine et al (2015) Functional plasticity of GAT-3 in avian Müller cells is regulated by neurons via a glutamatergic input. J Neurosci 82 42 PMID: 25700791
Calò et al (2005) Interactions between ephrin-B and metabotropic glutamate 1 receptors in brain tissue and cultured neurons. J Neurosci 25 2245 PMID: 15745950
Moreno et al (2011) Maternal influenza viral infection causes schizophrenia-like alterations of 5-HT2A and mGlu2 receptors in the adult offspring. J Neurosci 31 1863 PMID: 21289196
Owaisat et al (2012) In vivo comparison of harmine efficacy against psychostimulants: preferential inhibition of the cocaine response through a glutamatergic mechanism. Neurosci Lett 525 12 PMID: 22877698
Tallarida et al (2012) Glutamate carboxypeptidase II (GCPII) inhibitor displays anti-glutamate and anti-cocaine effects in an invertebrate assay. Amino Acids 42 2521 PMID: 21850438
Moreno et al (2012) Identification of three residues essential for 5-hydroxytryptamine 2A-metabotropic glutamate 2 (5-HT2A·mGlu2) receptor heteromerization and its psychoactive behavioral function. J Biol Chem 287 44301 PMID: 23129762
Do you know of a great paper that uses L-Glutamic acid from Tocris? Please let us know.
Reviews for L-Glutamic acid
Average Rating: 4.5 (Based on 2 Reviews.)
Have you used L-Glutamic acid?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Filter by:
Neuron glia culture.
By
Anonymous on 07/12/2020
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: Mixed neuron-glia
L-glutamate (10 or 100μM)
Incubate for 24h
works good.
By
Anonymous on 04/04/2020
Assay Type: In Vitro
Species: Rat
Cell Line/Tissue: Sprague-Dawley rats primary neuronal
10 μM L-Glutamic acid for 2 hours
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
GPCR Product Listing
A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:
- Rhodopsin-like Receptors
- Glutamate Receptors
- Frizzled Receptors
- GPCR Signaling
Pain Research Product Guide
A collection of over 280 products for pain research, the guide includes research tools for the study of:
- Nociception
- Ion Channels
- G-Protein-Coupled Receptors
- Intracellular Signaling
Metabotropic Glutamate Receptors Scientific Review
Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.
Epilepsy Poster
Epilepsy is a brain disease that affects 60 million people globally. More than 20 anti-seizure drugs are currently available, but these do not address the underlying causes of the condition. This poster summarizes current knowledge about the development of the condition and highlights some approaches that have disease-modifying effects in proof-of-concept studies.
Learning & Memory Poster
Recognition memory enables us to make judgements about whether or not we have encountered a particular stimulus before. This poster outlines the cellular mechanisms underlying recognition memory and its links to long-term depression, as well as the use of pharmacological intervention to assess the role of neurotransmitters in recognition memory.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.