L-Glutamic acid

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Cat.No. 0218 - L-Glutamic acid | C5H9NO4 | CAS No. 56-86-0
Description: Endogenous, non-selective agonist
Chemical Name: (S)-1-Aminopropane-1,3-dicarboxylic acid
Datasheet
Citations (7)
Literature

Biological Activity

The predominant excitatory transmitter in the mammalian central nervous system. Acts at ionotropic and metabotropic glutamate receptors. MNI-caged-L-glutamate (Cat. No. 1490) and D-Glutamic acid (Cat. No. 0217) are also available.

Technical Data

M. Wt 147.13
Formula C5H9NO4
Storage Store at RT
CAS Number 56-86-0
PubChem ID 33032
InChI Key WHUUTDBJXJRKMK-VKHMYHEASA-N
Smiles [H][C@@](CCC(O)=O)(N)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 100 mM in 1eq. NaOH

Preparing Stock Solutions

The following data is based on the product molecular weight 147.13. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 6.8 mL 33.98 mL 67.97 mL
5 mM 1.36 mL 6.8 mL 13.59 mL
10 mM 0.68 mL 3.4 mL 6.8 mL
50 mM 0.14 mL 0.68 mL 1.36 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Monaghan et al (1989) The excitatory amino acid receptors: their classes, pharmacology and distinct properties in the function of the central nervous system. Annu.Rev.Pharmacol.Toxicol. 29 365 PMID: 2543272

Watkins and Evans (1981) Excitatory amino acid transmitters. Annu.Rev.Pharmacol.Toxicol. 21 165 PMID: 6112965


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View Related Products by Product Action

View all Non-selective Metabotropic Glutamate Agonists

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7 Citations for L-Glutamic acid

Citations are publications that use Tocris products. Selected citations for L-Glutamic acid include:

Owaisat et al (2012) In vivo comparison of harmine efficacy against psychostimulants: preferential inhibition of the cocaine response through a glutamatergic mechanism. Neurosci Lett 525 12 PMID: 22877698

Tallarida et al (2012) Glutamate carboxypeptidase II (GCPII) inhibitor displays anti-glutamate and anti-cocaine effects in an invertebrate assay. Amino Acids 42 2521 PMID: 21850438

Moreno et al (2012) Identification of three residues essential for 5-hydroxytryptamine 2A-metabotropic glutamate 2 (5-HT2A·mGlu2) receptor heteromerization and its psychoactive behavioral function. J Biol Chem 287 44301 PMID: 23129762

Moreno et al (2011) Maternal influenza viral infection causes schizophrenia-like alterations of 5-HT2A and mGlu2 receptors in the adult offspring. J Neurosci 31 1863 PMID: 21289196

Galici et al (2006) Biphenyl-indanone A, a positive allosteric modulator of the metabotropic glutamate receptor subtype 2, has antipsychotic- and anxiolytic-like effects in mice. J Pharmacol Exp Ther 318 173 PMID: 16608916

Calò et al (2005) Interactions between ephrin-B and metabotropic glutamate 1 receptors in brain tissue and cultured neurons. J Neurosci 25 2245 PMID: 15745950

Schitine et al (2015) Functional plasticity of GAT-3 in avian Müller cells is regulated by neurons via a glutamatergic input. J Neurosci 82 42 PMID: 25700791


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