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Submit ReviewMDL 12330A hydrochloride
Description: Adenylyl cyclase inhibitor; also cyclic nucleotide PDE inhibitor
Chemical Name: (±)-N-[(1R*,2R*)-2-Phenylcyclopentyl]-azacyclotridec-1-en-2-amine hydrochloride
Purity: ≥98% (HPLC)
Biological Activity
Inhibitor of adenylyl cyclase. Also inhibits cAMP and cGMP phosphodiesterases, and blocks slow extracellular and store-operated Ca2+ entry into cells.
Technical Data
| M. Wt | 377.01 |
| Formula | C23H36N2.HCl |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 40297-09-4 |
| PubChem ID | 6917816 |
| InChI Key | CKOPQUCSDBVAQG-VROPFNGYSA-N |
| Smiles | C1(/N[C@@H]2[C@H]([C@]3=CC=CC=C3)CCC2)=N\CCCCCCCCCCC1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 7.54 | 20 | |
| ethanol | 7.54 | 20 |
Preparing Stock Solutions
The following data is based on the product molecular weight 377.01. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 13.26 mL | 66.31 mL | 132.62 mL |
| 1 mM | 2.65 mL | 13.26 mL | 26.52 mL |
| 2 mM | 1.33 mL | 6.63 mL | 13.26 mL |
| 10 mM | 0.27 mL | 1.33 mL | 2.65 mL |
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References
References are publications that support the biological activity of the product.
Guellaen et al (1977) RMI 12330 A, an inhibitor of adenylate cyclase in rat liver. Biochim.Biophys.Acta 484 465 PMID: 911855
Hunt and Evans (1980) RMI 12330A, an inhibitor of cyclic nucleotide phosphodiesterases and adenylate cyclase in kidney preparations. Biochim.Biophys.Acta 613 499 PMID: 6256001
van Rossum et al (2000) Ca2+ entry mediated by store depletion, S-nitrosylation, and TRP3 channels. Comparison of coupling and function. J.Biol.Chem. 275 28562 PMID: 10878007
If you know of a relevant reference for MDL 12330A hydrochloride, please let us know.
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2 Citations for MDL 12330A hydrochloride
Citations are publications that use Tocris products. Selected citations for MDL 12330A hydrochloride include:
Li et al (2017) Follicular Stimulating Hormone Accelerates Atherogenesis by Increasing Endothelial VCAM-1 Expression. Theranostics 7 4671 PMID: 29187895
Pietak et al (2019) Neural control of body-plan axis in regenerating planaria. PLoS Comput Biol 15 e1006904 PMID: 30990801
Do you know of a great paper that uses MDL 12330A hydrochloride from Tocris? Please let us know.
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Schizophrenia Poster
Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.