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MDL 12330A hydrochloride

Cat. No. 1436 2 Citations Submit a Review Datasheet / COA / SDS
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Cat.No. 1436 - MDL 12330A hydrochloride | C23H36N2.HCl | CAS No. 40297-09-4
Description: Adenylyl cyclase inhibitor; also cyclic nucleotide PDE inhibitor
Chemical Name: (±)-N-[(1R*,2R*)-2-Phenylcyclopentyl]-azacyclotridec-1-en-2-amine hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Reviews
Literature (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Inhibitor of adenylyl cyclase. Also inhibits cAMP and cGMP phosphodiesterases, and blocks slow extracellular and store-operated Ca2+ entry into cells.

Compound Libraries

MDL 12330A hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 377.01
Formula C23H36N2.HCl
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 40297-09-4
PubChem ID 6917816
InChI Key CKOPQUCSDBVAQG-VROPFNGYSA-N
Smiles C1(/N[C@@H]2[C@H]([C@]3=CC=CC=C3)CCC2)=N\CCCCCCCCCCC1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 7.54 20
ethanol 7.54 20

Preparing Stock Solutions

The following data is based on the product molecular weight 377.01. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 13.26 mL 66.31 mL 132.62 mL
1 mM 2.65 mL 13.26 mL 26.52 mL
2 mM 1.33 mL 6.63 mL 13.26 mL
10 mM 0.27 mL 1.33 mL 2.65 mL

Molarity Calculator

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Dilution Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the biological activity of the product.

Guellaen et al (1977) RMI 12330 A, an inhibitor of adenylate cyclase in rat liver. Biochim.Biophys.Acta 484 465 PMID: 911855

Hunt and Evans (1980) RMI 12330A, an inhibitor of cyclic nucleotide phosphodiesterases and adenylate cyclase in kidney preparations. Biochim.Biophys.Acta 613 499 PMID: 6256001

van Rossum et al (2000) Ca2+ entry mediated by store depletion, S-nitrosylation, and TRP3 channels. Comparison of coupling and function. J.Biol.Chem. 275 28562 PMID: 10878007

If you know of a relevant reference for MDL 12330A hydrochloride, please let us know.

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2 Citations for MDL 12330A hydrochloride

Citations are publications that use Tocris products. Selected citations for MDL 12330A hydrochloride include:

Li et al (2017) Follicular Stimulating Hormone Accelerates Atherogenesis by Increasing Endothelial VCAM-1 Expression. Theranostics 7 4671 PMID: 29187895

Pietak et al (2019) Neural control of body-plan axis in regenerating planaria. PLoS Comput Biol 15 e1006904 PMID: 30990801

Do you know of a great paper that uses MDL 12330A hydrochloride from Tocris? Please let us know.

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Literature in this Area

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