MDL 12330A hydrochloride

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Cat.No. 1436 - MDL 12330A hydrochloride | C23H36N2.HCl | CAS No. 40297-09-4
Description: Adenylyl cyclase inhibitor; also cyclic nucleotide PDE inhibitor
Chemical Name: (±)-N-[(1R*,2R*)-2-Phenylcyclopentyl]-azacyclotridec-1-en-2-amine hydrochloride
Purity: ≥98% (HPLC)

Biological Activity

Inhibitor of adenylyl cyclase. Also inhibits cAMP and cGMP phosphodiesterases, and blocks slow extracellular and store-operated Ca2+ entry into cells.

Technical Data

M. Wt 377.01
Formula C23H36N2.HCl
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 40297-09-4
PubChem ID 6917816
Smiles C1(/N[C@@H]2[C@H]([C@]3=CC=CC=C3)CCC2)=N\CCCCCCCCCCC1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 7.54 20
ethanol 7.54 20

Preparing Stock Solutions

The following data is based on the product molecular weight 377.01. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.65 mL 13.26 mL 26.52 mL
5 mM 0.53 mL 2.65 mL 5.3 mL
10 mM 0.27 mL 1.33 mL 2.65 mL
50 mM 0.05 mL 0.27 mL 0.53 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet


References are publications that support the products' biological activity.

Guellaen et al (1977) RMI 12330 A, an inhibitor of adenylate cyclase in rat liver. Biochim.Biophys.Acta 484 465 PMID: 911855

Hunt and Evans (1980) RMI 12330A, an inhibitor of cyclic nucleotide phosphodiesterases and adenylate cyclase in kidney preparations. Biochim.Biophys.Acta 613 499 PMID: 6256001

van Rossum et al (2000) Ca2+ entry mediated by store depletion, S-nitrosylation, and TRP3 channels. Comparison of coupling and function. J.Biol.Chem. 275 28562 PMID: 10878007

If you know of a relevant reference for MDL 12330A hydrochloride, please let us know.

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Keywords: adenylyl cyclase cyclic AMP GMP cAMP cGMP PDE phosphodiesterases store-operated store operated calcium SOCE channels MDL12330A Adenylyl Cyclase

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