MDL 12330A hydrochloride
Inhibitor of adenylyl cyclase. Also inhibits cAMP and cGMP phosphodiesterases, and blocks slow extracellular and store-operated Ca2+ entry into cells.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 377.01. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||13.26 mL||66.31 mL||132.62 mL|
|1 mM||2.65 mL||13.26 mL||26.52 mL|
|2 mM||1.33 mL||6.63 mL||13.26 mL|
|10 mM||0.27 mL||1.33 mL||2.65 mL|
References are publications that support the biological activity of the product.
Guellaen et al (1977) RMI 12330 A, an inhibitor of adenylate cyclase in rat liver. Biochim.Biophys.Acta 484 465 PMID: 911855
Hunt and Evans (1980) RMI 12330A, an inhibitor of cyclic nucleotide phosphodiesterases and adenylate cyclase in kidney preparations. Biochim.Biophys.Acta 613 499 PMID: 6256001
van Rossum et al (2000) Ca2+ entry mediated by store depletion, S-nitrosylation, and TRP3 channels. Comparison of coupling and function. J.Biol.Chem. 275 28562 PMID: 10878007
If you know of a relevant reference for MDL 12330A hydrochloride, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: MDL 12330A hydrochloride, MDL 12330A hydrochloride supplier, adenylyl, cyclase, cyclic, AMP, GMP, cAMP, cGMP, PDE, phosphodiesterases, store-operated, store, operated, calcium, SOCE, channels, MDL12330A, Adenylyl, Cyclase, Phosphodiesterases, General, Calcium, Signaling, Agents, 1436, Tocris Bioscience
1 Citation for MDL 12330A hydrochloride
Citations are publications that use Tocris products. Selected citations for MDL 12330A hydrochloride include:
Li et al (2017) Follicular Stimulating Hormone Accelerates Atherogenesis by Increasing Endothelial VCAM-1 Expression. Theranostics 7 4671 PMID: 29187895
Do you know of a great paper that uses MDL 12330A hydrochloride from Tocris? Please let us know.
Reviews for MDL 12330A hydrochloride
There are currently no reviews for this product. Be the first to review MDL 12330A hydrochloride and earn rewards!
Have you used MDL 12330A hydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.