MCOPPB trihydrochloride

Pricing Availability Delivery Time Qty
Cat.No. 3763 - MCOPPB trihydrochloride | C26H40N4.3HCl | CAS No. 1108147-88-1
Description: Potent NOP receptor agonist
Chemical Name: 1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-(3R)-3-piperidinyl-1H-benzimidazole trihydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

High affinity NOP receptor agonist (pKi = 10.07 for the human NOP receptor). Exhibits anxiolytic effects with no effect on memory or locomotion. Regarded as one of the most potent, non-peptide NOP full agonists in vitro.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries

MCOPPB trihydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 534.05
Formula C26H40N4.3HCl
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 1108147-88-1
PubChem ID 25208093
InChI Key DTIPEVOPCGEULQ-RFCADEKQSA-N
Smiles CC5(CCCCCCC5)N(CC4)CCC4N2C1=CC=CC=C1N=[C@@]2[C@H]3CNCCC3.Cl.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 32.04 60
water 16.02 30

Preparing Stock Solutions

The following data is based on the product molecular weight 534.05. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.87 mL 9.36 mL 18.72 mL
5 mM 0.37 mL 1.87 mL 3.74 mL
10 mM 0.19 mL 0.94 mL 1.87 mL
50 mM 0.04 mL 0.19 mL 0.37 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Hirao et al (2008) Pharmacological characterization of the newly synthesized nociceptin/orphanin FQ-receptor agonist 1-[1-(1-methylcyclooctyl)-4-piperidinyl]-2-[(3R)-3-piperidinyl]-1H-benzimidazole as an anxiolytic agent. J.Pharmacol.Sci. 106 361 PMID: 18319566

Hayashi et al (2009) Novel non-peptide nociceptin/orphanin FQ receptor agonist, 1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-[(3R)-3-piperidinyl]-1H-benzimidazole: design, synthesis, and structure-activity relationship of oral receptor occupancy in the brain f J.Med.Chem. 52 610 PMID: 19125610


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Keywords: MCOPPB trihydrochloride antianxiety anxiolytic NOP receptor full agonist NOP Receptors

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