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Cat.No. 0479 - Malonoben | C18H22N2O | CAS No. 10537-47-0
Description: Oxidative phosphorylation uncoupler
Chemical Name: 3,5-Di-tert-butyl-4-hydroxybenzylidenemalononitrile

Biological Activity

Potent uncoupler of oxidative phosphorylation.

Technical Data

M. Wt 282.38
Formula C18H22N2O
Storage Store at RT
CAS Number 10537-47-0
PubChem ID 16759147
Smiles OC1=C(C(C)(C)C)C=C(\C=C(C#N)/[N+]#[C-])C=C1C(C)(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 21.17 75

Preparing Stock Solutions

The following data is based on the product molecular weight 282.38. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.75 mM 4.72 mL 23.61 mL 47.22 mL
3.75 mM 0.94 mL 4.72 mL 9.44 mL
7.5 mM 0.47 mL 2.36 mL 4.72 mL
37.5 mM 0.09 mL 0.47 mL 0.94 mL

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References are publications that support the biological activity of the product.

Muraoka and Terada (1972) 3,5-Di-tert-butyl-4-hydroxybenzylidemalonitrile: a new powerful uncoupler of respiratory-chain phosphorylation. Biochim.Biophys.Acta 275 271 PMID: 4263281

Terada et al (1975) Some biochemical and physiochemical properties of the potent uncoupler SF 6847 hydroxybenzylidemalonitrile. Biochim.Biophys.Acta 387 519 PMID: 237542

Terada et al (1981) The interaction of highly active uncouplers with mitochondria. Biochim.Biophys.Acta 639 225 PMID: 7039674

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Keywords: Malonoben, Malonoben supplier, Oxidative, phosphorylation, uncoupler, Phosphorylation, 0479, Tocris Bioscience

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