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Cat.No. 0479 - Malonoben | C18H22N2O | CAS No. 10537-47-0
Description: Oxidative phosphorylation uncoupler
Chemical Name: 3,5-Di-tert-butyl-4-hydroxybenzylidenemalononitrile

Biological Activity

Potent uncoupler of oxidative phosphorylation.

Technical Data

M. Wt 282.38
Formula C18H22N2O
Storage Store at RT
CAS Number 10537-47-0
PubChem ID 16759147
Smiles OC1=C(C(C)(C)C)C=C(\C=C(C#N)/[N+]#[C-])C=C1C(C)(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 21.17 75

Preparing Stock Solutions

The following data is based on the product molecular weight 282.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.54 mL 17.71 mL 35.41 mL
5 mM 0.71 mL 3.54 mL 7.08 mL
10 mM 0.35 mL 1.77 mL 3.54 mL
50 mM 0.07 mL 0.35 mL 0.71 mL

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References are publications that support the products' biological activity.

Muraoka and Terada (1972) 3,5-Di-tert-butyl-4-hydroxybenzylidemalonitrile: a new powerful uncoupler of respiratory-chain phosphorylation. Biochim.Biophys.Acta 275 271 PMID: 4263281

Terada et al (1975) Some biochemical and physiochemical properties of the potent uncoupler SF 6847 hydroxybenzylidemalonitrile. Biochim.Biophys.Acta 387 519 PMID: 237542

Terada et al (1981) The interaction of highly active uncouplers with mitochondria. Biochim.Biophys.Acta 639 225 PMID: 7039674

If you know of a relevant reference for Malonoben, please let us know.

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Keywords: Malonoben, supplier, Oxidative, phosphorylation, uncoupler, Oxidative, Phosphorylation, Oxidative, Phosphorylation, Tocris Bioscience

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