m-CPP hydrochloride

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Cat.No. 0875 - m-CPP hydrochloride | C10H13ClN2.HCl | CAS No. 13078-15-4
Description: 5-HT2B/2C receptor agonist
Chemical Name: 1-(3-Chlorophenyl)piperazine hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

5-HT2C/2B receptor agonist/partial agonist; displays some activity at 5-HT2A and 5-HT1 receptors. pEC50 values are 7.09, 7.2, 6.65, 5.9 and 6.5 for human recombinant 5-HT2C, 2B and 2A, bovine 5-HT1A and rat 5-HT1B receptors respectively. Suppresses locomotor activity in rats in vivo.

Technical Data

M. Wt 233.14
Formula C10H13ClN2.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 13078-15-4
PubChem ID 25681
InChI Key MHXPYWFZULXYHT-UHFFFAOYSA-N
Smiles Cl.ClC1=CC=CC(=C1)N1CCNCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 100 mM in water

Preparing Stock Solutions

The following data is based on the product molecular weight 233.14. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.29 mL 21.45 mL 42.89 mL
5 mM 0.86 mL 4.29 mL 8.58 mL
10 mM 0.43 mL 2.14 mL 4.29 mL
50 mM 0.09 mL 0.43 mL 0.86 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Curzon et al (1990) m-CPP: a tool for studying behavioural responses associated with 5-HT1C receptors. TiPS 11 181 PMID: 2188399

Hoyer et al (1994) VII. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol.Rev. 46 157 PMID: 7938165

Lucki et al (1989) Effect of 1-(m-Chlorophenyl)piperazine and 1-(m-trifluoromethylphenyl)piperazine on locomotor activity. J.Pharmacol.Exp.Ther. 249 155 PMID: 2709329

Porter et al (1999) Functional characterization of agonists at recombinant human 5-HT2A, 5-HT2B and 5-HT2C receptors in CHO-K1 cells. Br.J.Pharmacol. 128 13 PMID: 10498829


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Keywords: m-CPP hydrochloride, supplier, 5-HT2B/2C, receptor, agonists, Serotonin, 5-HT2C, Receptors, 5-HT2B, 5-HT2B, Receptors, 5-HT2C, Receptors, 5-HT2B, Receptors, Tocris Bioscience

1 Citation for m-CPP hydrochloride

Citations are publications that use Tocris products. Selected citations for m-CPP hydrochloride include:

Moya et al (2011) Altered 5-HT2C receptor agonist-induced responses and 5-HT2C receptor RNA editing in the amygdala of serotonin transporter knockout mice. BMC Pharmacol 11 3 PMID: 21473759


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