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5-HT2C/2B receptor agonist/partial agonist; displays some activity at 5-HT2A and 5-HT1 receptors. pEC50 values are 7.09, 7.2, 6.65, 5.9 and 6.5 for human recombinant 5-HT2C, 2B and 2A, bovine 5-HT1A and rat 5-HT1B receptors respectively. Suppresses locomotor activity in rats in vivo.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 233.14. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.29 mL||21.45 mL||42.89 mL|
|5 mM||0.86 mL||4.29 mL||8.58 mL|
|10 mM||0.43 mL||2.14 mL||4.29 mL|
|50 mM||0.09 mL||0.43 mL||0.86 mL|
References are publications that support the biological activity of the product.
Curzon et al (1990) m-CPP: a tool for studying behavioural responses associated with 5-HT1C receptors. TiPS 11 181 PMID: 2188399
Hoyer et al (1994) VII. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol.Rev. 46 157 PMID: 7938165
Lucki et al (1989) Effect of 1-(m-Chlorophenyl)piperazine and 1-(m-trifluoromethylphenyl)piperazine on locomotor activity. J.Pharmacol.Exp.Ther. 249 155 PMID: 2709329
Porter et al (1999) Functional characterization of agonists at recombinant human 5-HT2A, 5-HT2B and 5-HT2C receptors in CHO-K1 cells. Br.J.Pharmacol. 128 13 PMID: 10498829
If you know of a relevant reference for m-CPP hydrochloride, please let us know.
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Keywords: m-CPP hydrochloride, m-CPP hydrochloride supplier, 5-HT2B/2C, receptor, agonists, Serotonin, 5-HT2C, Receptors, 5-HT2B, 0875, Tocris Bioscience
1 Citation for m-CPP hydrochloride
Citations are publications that use Tocris products. Selected citations for m-CPP hydrochloride include:
Moya et al (2011) Altered 5-HT2C receptor agonist-induced responses and 5-HT2C receptor RNA editing in the amygdala of serotonin transporter knockout mice. BMC Pharmacol 11 3 PMID: 21473759
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.