m-CPP hydrochloride

Pricing Availability   Qty
Cat.No. 0875 - m-CPP hydrochloride | C10H13ClN2.HCl | CAS No. 13078-15-4
Description: 5-HT2B and 5-HT2C agonist
Chemical Name: 1-(3-Chlorophenyl)piperazine hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (3)

Biological Activity

5-HT2C/2B receptor agonist/partial agonist; displays some activity at 5-HT2A and 5-HT1 receptors. pEC50 values are 7.09, 7.2, 6.65, 5.9 and 6.5 for human recombinant 5-HT2C, 2B and 2A, bovine 5-HT1A and rat 5-HT1B receptors respectively. Suppresses locomotor activity in rats in vivo.

Technical Data

M. Wt 233.14
Formula C10H13ClN2.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 13078-15-4
PubChem ID 25681
InChI Key MHXPYWFZULXYHT-UHFFFAOYSA-N
Smiles Cl.ClC1=CC=CC(=C1)N1CCNCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 100 mM in water

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:

References

References are publications that support the biological activity of the product.

Curzon et al (1990) m-CPP: a tool for studying behavioural responses associated with 5-HT1C receptors. TiPS 11 181 PMID: 2188399

Hoyer et al (1994) VII. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol.Rev. 46 157 PMID: 7938165

Lucki et al (1989) Effect of 1-(m-Chlorophenyl)piperazine and 1-(m-trifluoromethylphenyl)piperazine on locomotor activity. J.Pharmacol.Exp.Ther. 249 155 PMID: 2709329

Porter et al (1999) Functional characterization of agonists at recombinant human 5-HT2A, 5-HT2B and 5-HT2C receptors in CHO-K1 cells. Br.J.Pharmacol. 128 13 PMID: 10498829


If you know of a relevant reference for m-CPP hydrochloride, please let us know.

View Related Products by Target

View Related Products by Product Action

View all 5-HT2B Receptor Agonists

Keywords: m-CPP hydrochloride, m-CPP hydrochloride supplier, 5-HT2B/2C, receptor, agonists, Serotonin, 5-HT2C, Receptors, 5-HT2B, 0875, Tocris Bioscience

1 Citation for m-CPP hydrochloride

Citations are publications that use Tocris products. Selected citations for m-CPP hydrochloride include:

Moya et al (2011) Altered 5-HT2C receptor agonist-induced responses and 5-HT2C receptor RNA editing in the amygdala of serotonin transporter knockout mice. BMC Pharmacol 11 3 PMID: 21473759


Do you know of a great paper that uses m-CPP hydrochloride from Tocris? Please let us know.

Reviews for m-CPP hydrochloride

There are currently no reviews for this product. Be the first to review m-CPP hydrochloride and earn rewards!

Have you used m-CPP hydrochloride?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
5-HT Receptors

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

Depression

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.