Lys-γ3-MSH

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Cat.No. 3611 - Lys-gamma3-MSH | Lys-Tyr-Val-Met-Gly-His-Phe-Arg-Trp-Asp-Arg-Phe-Gly-Arg-Arg-Asn-Ser-Ser-Ser-Ser-Gly-Ser-Ser-Gly-Ala-Gly-Gln | CAS No. 156159-18-1
Description: Pro-opiomelanocortin (POMC) derived peptide
Datasheet
Citations
Reviews
Literature

Biological Activity

Pro-opiomelanocortin (POMC) derived peptide. Potentiates the steriodogenic action of corticotrophin on the adrenal cortex, possibly via the MC3 receptor. Potently stimulates lipolysis via activation of hormone-sensitive lipase (HSL).

Technical Data

M. Wt 3018.27
Formula C128H193N45O39S
Sequence KYVMGHFRWDRFGRRNSSSSGSSGAGQ
Storage Store at -20°C
CAS Number 156159-18-1
PubChem ID 90488867
InChI Key XWFHPHMLENMPDT-KLQUGMGCSA-N
Smiles [H]N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCSC)C(=O)NCC(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility Soluble to 1 mg/ml in 10% acetonitrile / water

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Harmer et al (2008) Evidence of a possible role fo Lys-γ3-MSH in the regulation of adipocyte function. J.Endocrinol. 196 149 PMID: 18180326

Bicknell et al (2009) Lys-gamma3-MSH: a global regulator of hormone-sensitive lipase activity? Mol.Cell.Endocrinol. 300 71 PMID: 18977407

Harmer and Bicknell (2004) The role of the melanocortin 3 receptor in mediating the effects of gamma-MSH peptides on the adrenal. Endocrine Res. 30 629


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Keywords: Lys-gamma3-MSH, Lys-gamma3-MSH supplier, Pro-opiomelanocortin, POMC, hormone-sensitive, lipase, activators, HSL, melanocortin, receptors, Hydrolases, Lys-γ3-MSH, Lys-gamma3-MSH, Lys-γ3-Melanocyte-stimulating, Lys-gamma3-Melanocyte-stimulating, hormone, Melanocortin, Receptors, Other, 3611, Tocris Bioscience

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Literature in this Area

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