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High affinity and selective RARγ antagonist (Ki values are 1.1 nM, >1.7 μM and >2.9 μM for RARγ, RARα and RARβ respectively). Displays analgesic efficacy in a mouse model of osteoarthritis-like joint pain.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 578.74. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||8.64 mL||43.2 mL||86.39 mL|
|1 mM||1.73 mL||8.64 mL||17.28 mL|
|2 mM||0.86 mL||4.32 mL||8.64 mL|
|10 mM||0.17 mL||0.86 mL||1.73 mL|
References are publications that support the biological activity of the product.
Hughes et al (2016) Identification of potent and selective retinoic acid receptor gamma (RARγ) antagonists for the treatment of osteoarthritis pain using structure based drug design. Bioorg.Med.Chem.Letts. 26 3274 PMID: 27261179
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Keywords: LY 2955303, LY 2955303 supplier, LY2955303, selective, retinoic, acid, receptor, gamma, RARg, antagonists, antagonism, osteoarthritis, high, affinity, Retinoic, Acid, Receptors, 5984, Tocris Bioscience
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