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Biological Activity for LY 2955303
LY 2955303 is a high affinity and selective RARγ antagonist (Ki values are 1.1 nM, >1.7 μM and >2.9 μM for RARγ, RARα and RARβ respectively). Displays analgesic efficacy in a mouse model of osteoarthritis-like joint pain.
Compound Libraries for LY 2955303
Technical Data for LY 2955303
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for LY 2955303
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for LY 2955303
The following data is based on the product molecular weight 578.74. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||8.64 mL||43.2 mL||86.39 mL|
|1 mM||1.73 mL||8.64 mL||17.28 mL|
|2 mM||0.86 mL||4.32 mL||8.64 mL|
|10 mM||0.17 mL||0.86 mL||1.73 mL|
References for LY 2955303
References are publications that support the biological activity of the product.
Hughes et al (2016) Identification of potent and selective retinoic acid receptor gamma (RARγ) antagonists for the treatment of osteoarthritis pain using structure based drug design. Bioorg.Med.Chem.Letts. 26 3274 PMID: 27261179
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Citations for LY 2955303
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Literature in this Area
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