High affinity and selective RARγ antagonist (Ki values are 1.1 nM, >1.7 μM and >2.9 μM for RARγ, RARα and RARβ respectively). Displays analgesic efficacy in a mouse model of osteoarthritis-like joint pain.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 578.74. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||8.64 mL||43.2 mL||86.39 mL|
|1 mM||1.73 mL||8.64 mL||17.28 mL|
|2 mM||0.86 mL||4.32 mL||8.64 mL|
|10 mM||0.17 mL||0.86 mL||1.73 mL|
References are publications that support the biological activity of the product.
Hughes et al (2016) Identification of potent and selective retinoic acid receptor gamma (RARγ) antagonists for the treatment of osteoarthritis pain using structure based drug design. Bioorg.Med.Chem.Letts. 26 3274 PMID: 27261179
If you know of a relevant reference for LY 2955303, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: LY 2955303, LY 2955303 supplier, LY2955303, selective, retinoic, acid, receptor, gamma, RARg, antagonists, antagonism, osteoarthritis, high, affinity, Retinoic, Acid, Receptors, 5984, Tocris Bioscience
Citations for LY 2955303
Citations are publications that use Tocris products.
Currently there are no citations for LY 2955303. Do you know of a great paper that uses LY 2955303 from Tocris? Please let us know.
Reviews for LY 2955303
There are currently no reviews for this product. Be the first to review LY 2955303 and earn rewards!
Have you used LY 2955303?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.