LY 2389575 hydrochloride

Discontinued Product

LY 2389575 hydrochloride (Cat. No. 4969) has been withdrawn from sale for commercial reasons.
Description: Selective negative allosteric modulator of mGlu3 receptors
Chemical Name: (3S)-N-(2,4-Dichlorobenzyl)-1-(5-bromopyrimidin-2-yl)pyrrolidinyl-3-amine hydrochloride
Purity: ≥98% (HPLC)
Literature (5)

Biological Activity for LY 2389575 hydrochloride

LY 2389575 hydrochloride is a selective negative allosteric modulator of mGlu3 (IC50 = 190 nM). Exhibits > 65-fold selectivity for mGlu3 over other mGlu receptors. Abolishes the neuroprotective action of LY 379268 against amyloid β toxicity in mixed cortical neuronal and astrocyte cell cultures.

Technical Data for LY 2389575 hydrochloride

M. Wt 438.58
Formula C15H15BrCl2N4.HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 885104-09-6
PubChem ID 11503054
Smiles ClC1=CC(Cl)=CC=C1CN[C@@H]2CN(C3=NC=C(Br)C=N3)CC2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for LY 2389575 hydrochloride

References for LY 2389575 hydrochloride

References are publications that support the biological activity of the product.

Caraci et al (2011) Targeting group II metabotropic glutamate (mGlu) receptors for the treatment of psychosis associated with Alzheimer's disease: selective activation of mGlu2 receptors amplifies beta-amyloid toxicity in cultured neurons, whereas dual activation of mGl Mol.Pharmacol. 79 618 PMID: 21159998

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Citations for LY 2389575 hydrochloride

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Currently there are no citations for LY 2389575 hydrochloride.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Metabotropic Glutamate Receptors Scientific Review

Metabotropic Glutamate Receptors Scientific Review

Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.

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