LY 2183240

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Cat.No. 2452 - LY 2183240 | C17H17N5O | CAS No. 874902-19-9
Description: Highly potent anandamide uptake inhibitor; also inhibits FAAH
Chemical Name: 5-[(1,1'-Biphenyl]-4-yl)methyl]-N,N-dimethyl-1H-tetrazole-1-carboxamide
Purity: ≥98% (HPLC)
Citations (1)
Literature (3)

Biological Activity for LY 2183240

LY 2183240 is a novel and highly potent blocker of anandamide uptake (IC50 = 270 pM). Inhibits fatty acid amide hydrolase (FAAH) activity (IC50 = 12.4 nM). Following i.p. administration in rats, increases brain anandamide concentration and exerts antinociceptive effects in formalin model of pain.

Licensing Information

Sold under license from Eli Lilly and Company

Technical Data for LY 2183240

M. Wt 307.35
Formula C17H17N5O
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 874902-19-9
PubChem ID 11507802
Smiles CN(C)C(=O)N1N=NN=C1CC1=CC=C(C=C1)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for LY 2183240

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 30.74 100
ethanol 15.37 50 with gentle warming

Preparing Stock Solutions for LY 2183240

The following data is based on the product molecular weight 307.35. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.25 mL 16.27 mL 32.54 mL
5 mM 0.65 mL 3.25 mL 6.51 mL
10 mM 0.33 mL 1.63 mL 3.25 mL
50 mM 0.07 mL 0.33 mL 0.65 mL

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Product Datasheets for LY 2183240

Certificate of Analysis / Product Datasheet
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References for LY 2183240

References are publications that support the biological activity of the product.

Dickason-Chesterfield et al (2006) Pharmacological characterization of endocannabinoid transport and fatty acid amide hydrolase inhibitors. Cell Mol.Neurobiol. 26 407 PMID: 16736384

Alexander and Cravat (2006) The putative endocannabinoid transport blocker LY2183240 is a potent inhibitor of FAAH and several other brain serine hydrolases. J.Am.Chem.Soc. 128 9699 PMID: 16866524

Moore et al (2005) Identification of a high-affinity binding site involved in the transport of endocannabinoids. Proc.Natl.Acad.Sci.USA 102 17852

If you know of a relevant reference for LY 2183240, please let us know.

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Keywords: LY 2183240, LY 2183240 supplier, FAAH, inhibitors, inhibits, anandamide, reuptake, potent, Anandamide, Amidase, Fatty, Acid, Amide, Hydrolases, AMT, Transporters, cannabinoids, Monoamine, Neurotransmitter, LY2183240, Cannabinoid, Hydrolase, (FAAH), Other, Cannabinoids, 2452, Tocris Bioscience

1 Citation for LY 2183240

Citations are publications that use Tocris products. Selected citations for LY 2183240 include:

Gonzalez-Islas et al (2012) Tonic and transient endocannabinoid regulation of AMPAergic miniature postsynaptic currents and homeostatic plasticity in embryonic motor networks. PLoS One 32 13597 PMID: 23015449

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Literature in this Area

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A collection of over 280 products for pain research, the guide includes research tools for the study of:

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