LY 2087101

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Cat.No. 4141 - LY 2087101 | C15H11FN2OS2 | CAS No. 913186-74-0
Description: Potentiator of α7 nAChRs
Chemical Name: [2-[(4-Fluorophenyl)amino]-4-methyl-5-thiazolyl]-3-thienylmethanone
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Allosteric potentiator of α7, α4β2 and α4β4 nAChRs; displays selectivity against α3β4 nAChRs. Thought to potentiate agonist-evoked α7 responses by binding within the nAChR transmembrane region.

Technical Data

M. Wt 318.39
Formula C15H11FN2OS2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 913186-74-0
PubChem ID 11964458
InChI Key PEAMDZVDNYENPN-UHFFFAOYSA-N
Smiles O=C(C3=CSC=C3)C1=C(C)N=C(NC2=CC=C(F)C=C2)S1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 31.84 100
ethanol 3.18 10

Preparing Stock Solutions

The following data is based on the product molecular weight 318.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.14 mL 15.7 mL 31.41 mL
5 mM 0.63 mL 3.14 mL 6.28 mL
10 mM 0.31 mL 1.57 mL 3.14 mL
50 mM 0.06 mL 0.31 mL 0.63 mL

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Product Datasheets

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References

References are publications that support the products' biological activity.

Broad et al (2006) Identification and pharmacological profile of a new class of selective nicotinic acetylcholine receptor potentiators. J.Pharmacol.Exp.Ther. 318 1108 PMID: 16738207

Young et al (2008) Potentiation of α7 nicotinic acetylcholine receptors via an allosteric transmembrane site. Proc.Natl.Acad.Sci. 105 14686 PMID:


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Keywords: allosteric potentiators modulators nicotinic acetylcholine receptors nAChRs alpha7 α7 a7 LY2087101 Nicotinic (a7) Receptors

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