LY 2087101

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Description: Allosteric potentiator of α7, α4β2 and α4β4 nAChRs
Chemical Name: [2-[(4-Fluorophenyl)amino]-4-methyl-5-thiazolyl]-3-thienylmethanone
Purity: ≥98% (HPLC)
Citations (1)
Literature (3)

Biological Activity for LY 2087101

LY 2087101 is an allosteric potentiator of α7, α4β2 and α4β4 nAChRs; displays selectivity against α3β4 nAChRs. Thought to potentiate agonist-evoked α7 responses by binding within the nAChR transmembrane region.

Compound Libraries for LY 2087101

LY 2087101 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for LY 2087101

M. Wt 318.39
Formula C15H11FN2OS2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 913186-74-0
PubChem ID 11964458
Smiles O=C(C3=CSC=C3)C1=C(C)N=C(NC2=CC=C(F)C=C2)S1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for LY 2087101

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 31.84 100
ethanol 3.18 10

Preparing Stock Solutions for LY 2087101

The following data is based on the product molecular weight 318.39. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.14 mL 15.7 mL 31.41 mL
5 mM 0.63 mL 3.14 mL 6.28 mL
10 mM 0.31 mL 1.57 mL 3.14 mL
50 mM 0.06 mL 0.31 mL 0.63 mL

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Product Datasheets for LY 2087101

Certificate of Analysis / Product Datasheet
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References for LY 2087101

References are publications that support the biological activity of the product.

Broad et al (2006) Identification and pharmacological profile of a new class of selective nicotinic acetylcholine receptor potentiators. J.Pharmacol.Exp.Ther. 318 1108 PMID: 16738207

Young et al (2008) Potentiation of α7 nicotinic acetylcholine receptors via an allosteric transmembrane site. Proc.Natl.Acad.Sci.U.S.A. 105 14686 PMID: 1879106

If you know of a relevant reference for LY 2087101, please let us know.

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1 Citation for LY 2087101

Citations are publications that use Tocris products. Selected citations for LY 2087101 include:

Haiyang et al (2020) Studying Nicotinic Acetylcholine Receptors Using the IonFlux™ Microfluidic-Based Automated Patch-Clamp System with Continuous Perfusion and Fast Solution Exchange. Curr Protoc Pharmacol 88 e73 PMID: 32068960

Do you know of a great paper that uses LY 2087101 from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Nicotinic ACh Receptors Scientific Review

Nicotinic ACh Receptors Scientific Review

Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.

Alzheimer's Disease Poster

Alzheimer's Disease Poster

Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.

Learning & Memory Poster

Learning & Memory Poster

Recognition memory enables us to make judgements about whether or not we have encountered a particular stimulus before. This poster outlines the cellular mechanisms underlying recognition memory and its links to long-term depression, as well as the use of pharmacological intervention to assess the role of neurotransmitters in recognition memory.