Pricing Availability   Qty
Cat.No. 4084 - LPYFD-NH2 | Leu-Pro-Tyr-Phe-Asp-NH2 | CAS No. 700361-48-4
Description: Binds Aβ; protects from aggregation induced toxicity
Literature (2)

Biological Activity

Neuroprotective peptide that binds to amyloid beta (Aβ). Protects neurons against toxic effects of Aβ (1-42) in vitro and in vivo. Potential therapeutic in the treatment of Alzheimer's Disease.

Technical Data

M. Wt 652.75
Formula C33H44N6O8
Sequence LPYFD-NH2

(Modifications: Asp-5 = C-terminal amide)

Storage Store at -20°C
CAS Number 700361-48-4
PubChem ID 90488910
Smiles [H]N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(O)=O)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 2 mg/ml in 10% acetonitrile / water


References are publications that support the biological activity of the product.

Szegedi et al (2005) Pentapeptides derived from Aβ1-42 protect neurons from the modulatory effects of Aβ fibrils- an in vitro and in vivo electrophysiological study. Neurobiology of Disease 18 499 PMID: 15755677

Juhasz et al (2009) An intraperitoneally administered pentapeptide protects against Aβ (1-42) induced neuronal excitation in vivo. J.Alzheimer's Dis. 16 189

If you know of a relevant reference for LPYFD-NH2, please let us know.

View Related Products by Target

Keywords: LPYFD-NH2, LPYFD-NH2 supplier, LPYFDNH2, neuroprotective, amyloid, sequence-derived, peptides, binds, beta, Ab, Aβ, Alzheimers, amyloidbeta, amyloidb, amyloidβ, Amyloid, Beta, Peptides, 4084, Tocris Bioscience

Citations for LPYFD-NH2

Citations are publications that use Tocris products.

Currently there are no citations for LPYFD-NH2. Do you know of a great paper that uses LPYFD-NH2 from Tocris? Please let us know.

Reviews for LPYFD-NH2

There are currently no reviews for this product. Be the first to review LPYFD-NH2 and earn rewards!

Have you used LPYFD-NH2?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Neurodegeneration Product Guide

A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

  • Alzheimer's disease
  • Parkinson's disease
  • Huntington's disease

Alzheimer's Poster

Alzheimer's disease (AD) is a degenerative brain disease and the most common cause of dementia, affecting approximately 47 million people worldwide. Updated in 2015, this poster summarizes the structural and functional changes observed in the progression of this neurodegenerative disease, as well as classic AD drug targets.