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Cat.No. 4084 - LPYFD-NH2 | Leu-Pro-Tyr-Phe-Asp-NH2 | CAS No. 700361-48-4
Description: Binds Aβ; protects from aggregation induced toxicity

Biological Activity

Neuroprotective peptide that binds to amyloid beta (Aβ). Protects neurons against toxic effects of Aβ (1-42) in vitro and in vivo. Potential therapeutic in the treatment of Alzheimer's Disease.

Technical Data

M. Wt 652.75
Formula C33H44N6O8
Sequence LPYFD-NH2

(Modifications: Asp-5 = C-terminal amide)

Storage Store at -20°C
CAS Number 700361-48-4
PubChem ID 90488910
Smiles [H]N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(O)=O)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 2 mg/ml in 10% acetonitrile / water

Preparing Stock Solutions

The following data is based on the product molecular weight 652.75. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.53 mL 7.66 mL 15.32 mL
5 mM 0.31 mL 1.53 mL 3.06 mL
10 mM 0.15 mL 0.77 mL 1.53 mL
50 mM 0.03 mL 0.15 mL 0.31 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Szegedi et al (2005) Pentapeptides derived from Aβ1-42 protect neurons from the modulatory effects of Aβ fibrils- an in vitro and in vivo electrophysiological study. Neurobiology of Disease 18 499 PMID: 15755677

Juhasz et al (2009) An intraperitoneally administered pentapeptide protects against Aβ (1-42) induced neuronal excitation in vivo. J.Alzheimer's Dis. 16 189 PMID:

If you know of a relevant reference for LPYFD-NH2, please let us know.

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Literature in this Area

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Neurodegeneration Product Guide

A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

  • Alzheimer's disease
  • Parkinson's disease
  • Huntington's disease

Alzheimer's Poster

Alzheimer's disease (AD) is a degenerative brain disease and the most common cause of dementia, affecting approximately 47 million people worldwide. Updated in 2015, this poster summarizes the structural and functional changes observed in the progression of this neurodegenerative disease, as well as classic AD drug targets.