LP 99

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Cat.No. 5496 - LP 99 | C26H30ClN3O4S | CAS No. 1808951-93-0
Description: Selective BRD7 and BRD9 inhibitor
Chemical Name: N-[(2R,3S)-2-(4-Chlorophenyl)-1-(1,2-dihydro-1,4-dimethyl-2-oxo-7-quinolinyl)-6-oxo-3-piperidinyl]-2-methyl-1-propanesulfonamide
Purity: ≥98% (HPLC)
Literature (5)

Biological Activity for LP 99

LP 99 is a selective BRD7 and BRD9 inhibitor (Kd values are 99 and 909 nM, respectively) that exhibits selectivity for BRD7/9 over a panel of 48 bromodomains (at 10 μM). LP 99 inhibits interactions with histones H3.3 and H4 at low micromolar concentrations, and decreases the level of IL-6 secreted from LPS-stimulated THP-1 cells, in vitro. A negative control for LP 99, ent-LP 99 (Cat.No. 5497), is also available.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the LP 99 probe summary on the SGC website.

External Portal Information for LP 99

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of LP 99 is reviewed on the chemical probes website.

Compound Libraries for LP 99

LP 99 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for LP 99

M. Wt 516.05
Formula C26H30ClN3O4S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1808951-93-0
PubChem ID 91827372
Smiles CC(C(C=CC(N1[C@@H]([C@H](CCC1=O)NS(=O)(CC(C)C)=O)C2=CC=C(C=C2)Cl)=C3)=C3N4C)=CC4=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for LP 99

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 51.6 100
ethanol 51.6 100

Preparing Stock Solutions for LP 99

The following data is based on the product molecular weight 516.05. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.94 mL 9.69 mL 19.38 mL
5 mM 0.39 mL 1.94 mL 3.88 mL
10 mM 0.19 mL 0.97 mL 1.94 mL
50 mM 0.04 mL 0.19 mL 0.39 mL

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References for LP 99

References are publications that support the biological activity of the product.

Clark et al (2015) LP99: discovery and synthesis of the first selective BRD7/9 bromodomain inhibitor. Angew.Chem.Int.Ed.Engl. 54 6217 PMID: 25864491

If you know of a relevant reference for LP 99, please let us know.

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Keywords: LP 99, LP 99 supplier, LP99, selective, BRD7, BRD9, bromodomain, inhibitors, inhibits, Bromodomains, 5496, Tocris Bioscience

Citations for LP 99

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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