Pricing Availability   Qty
Description: Peripheral H1 antagonist; antiallergic agent
Alternative Names: SCH 29851
Chemical Name: 4-(8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinecarboxylic acid ethyl ester
Purity: ≥99% (HPLC)
Literature (1)

Biological Activity for Loratidine

Loratidine is a peripheral histamine H1 receptor antagonist (Ki = 35 nM); devoid of central effects. Orally active antiallergic agent.

Compound Libraries for Loratidine

Loratidine is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Loratidine

M. Wt 382.88
Formula C22H23ClN2O2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 79794-75-5
PubChem ID 3957
Smiles CCOC(=O)N1CC\C(CC1)=C1/C2=NC=CC=C2CCC2=C1C=CC(Cl)=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Loratidine

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 9.57 25
ethanol 38.29 100

Preparing Stock Solutions for Loratidine

The following data is based on the product molecular weight 382.88. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.61 mL 13.06 mL 26.12 mL
5 mM 0.52 mL 2.61 mL 5.22 mL
10 mM 0.26 mL 1.31 mL 2.61 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

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References for Loratidine

References are publications that support the biological activity of the product.

Ahn and Barnett (1986) Selective displacement of [3H]mepyramine from peripheral vs. central nervous system receptors by loratadine, a non-sedating antihistamine. Eur.J.Pharmacol. 127 153 PMID: 2875889

Barnett et al (1984) Evaluation of the CNS properties of SCH 29851, a potential non-sedating antihistamine. Agents Actions 14 590 PMID: 6236679

Kreutner et al (1987) Antiallergic activity of loratidine, a non-sedating antihistamine. Allergy 42 57 PMID: 2436504

If you know of a relevant reference for Loratidine, please let us know.

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Keywords: Loratidine, Loratidine supplier, Peripheral, H1, antagonists, anti-allergic, agent, Receptors, Histamine, histaminergic, SCH29851, SCH, 29851, 1944, Tocris Bioscience

Citations for Loratidine

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Currently there are no citations for Loratidine. Do you know of a great paper that uses Loratidine from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Histamine Receptors Scientific Review

Histamine Receptors Scientific Review

Written by Iwan de Esch and Rob Leurs, this review provides a synopsis of the different histamine receptor subtypes and the ligands that act upon them; compounds available from Tocris are listed.