Loratidine

Pricing Availability Delivery Time Qty
Cat.No. 1944 - Loratidine | C22H23ClN2O2 | CAS No. 79794-75-5
Description: Peripheral H1 antagonist; antiallergic agent
Alternative Names: SCH 29851
Chemical Name: 4-(8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinecarboxylic acid ethyl ester
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Peripheral histamine H1 receptor antagonist (Ki = 35 nM); devoid of central effects. Orally active antiallergic agent.

Compound Libraries

Loratidine is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 382.88
Formula C22H23ClN2O2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 79794-75-5
PubChem ID 3957
InChI Key JCCNYMKQOSZNPW-UHFFFAOYSA-N
Smiles CCOC(=O)N1CC\C(CC1)=C1/C2=NC=CC=C2CCC2=C1C=CC(Cl)=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 9.57 25
ethanol 38.29 100

Preparing Stock Solutions

The following data is based on the product molecular weight 382.88. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.61 mL 13.06 mL 26.12 mL
5 mM 0.52 mL 2.61 mL 5.22 mL
10 mM 0.26 mL 1.31 mL 2.61 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Ahn and Barnett (1986) Selective displacement of [3H]mepyramine from peripheral vs. central nervous system receptors by loratadine, a non-sedating antihistamine. Eur.J.Pharmacol. 127 153 PMID: 2875889

Barnett et al (1984) Evaluation of the CNS properties of SCH 29851, a potential non-sedating antihistamine. Agents Actions 14 590 PMID: 6236679

Kreutner et al (1987) Antiallergic activity of loratidine, a non-sedating antihistamine. Allergy 42 57 PMID: 2436504


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Keywords: Loratidine, supplier, Peripheral, H1, antagonists, anti-allergic, agent, Receptors, Histamine, histaminergic, SCH29851, SCH, 29851, Histamine, H1, Receptors, Histamine, H1, Receptors, Tocris Bioscience

Citations for Loratidine

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