You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Highly potent and selective HIV-1 protease inhibitor (IC50 = 6.5 nM, HIV cultured in peripheral blood mononuclear cells; Ki = 1.3 pM). Displays >105-fold selectivity for HIV-1 protease over mammalian proteases including renin and cathepsin D and E. Inhibits HIV-1 protease in patient HIV isolates displaying mutations that confer resistance to ritonavir (Cat. No. 5856) (IC50 values in 5 - 50 nM range). Also inhibits SARS-CoV-2 replication in vitro (IC50 = 26 μM)
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 628.8. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.59 mL||7.95 mL||15.9 mL|
|5 mM||0.32 mL||1.59 mL||3.18 mL|
|10 mM||0.16 mL||0.8 mL||1.59 mL|
|50 mM||0.03 mL||0.16 mL||0.32 mL|
References are publications that support the biological activity of the product.
Sham et al (1998) ABT-378, a highly potent inhibitor of the human immunodeficiency virus protease. Antimicrob.Agents Chemother. 42 3218 PMID: 9835517
Carrillo et al (1998) In vitro selection and characterization of human immunodeficiency virus type 1 variants with increased resistance to ABT-378, a novel protease inhibitor. J.Virol. 72 7532 PMID: 9696850
Choy et al (2020) Remdesivir, lopinavir, emetine, and homoharringtonine inhibit SARS-CoV-2 replication in vitro. Antiviral Res. 178 PMID: 32251767
If you know of a relevant reference for Lopinavir, please let us know.
View Related Products by Product Action
Keywords: Lopinavir, Lopinavir supplier, ABT, 378, lopinavir, HIV-1, protease, inhibitors, inhibits, human, immunodeficiency, virus, AIDS, aquired, syndrome, hight, potent, selective, ABT-378, Other, Proteases, Antivirals, COVID-19, 7052, Tocris Bioscience
Citations for Lopinavir
Citations are publications that use Tocris products.
Currently there are no citations for Lopinavir. Do you know of a great paper that uses Lopinavir from Tocris? Please let us know.
Reviews for Lopinavir
There are currently no reviews for this product. Be the first to review Lopinavir and earn rewards!
Have you used Lopinavir?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
New Product Guide [Spring/Summer 2019]
Our new product guide highlights over 215 new products added to the Tocris Bioscience range during the first half of 2019.
- 7-TM Receptors
- Enzyme-Linked Receptors
- Ion Channels
- Nuclear Receptors
- Fluorescent Imaging
- Signal Transduction
- Stem Cells